A Review of Monolaurin and Lauric Acid:<i>Natural Virucidal and Bactericidal Agents</i>

Lieberman, Shari; Enig, Mary G.; Preuss, Harry G.

doi:10.1089/act.2006.12.310

Cited by 113 publications

(84 citation statements)

References 12 publications

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“…The oil is obtained of coconut kernel and it is a natural functional food rich in medium-chain triglycerides (MCTs), mainly the saturated fatty acids with approximately 50% of the lauric acid (Liau et al 2011). The lauric acid has potential virucidal and bactericidal actions (Lieberman et al 2006). It is absorbed directly into the portal circulation and transported to the liver for rapid oxidation.…”

Section: Introductionmentioning

confidence: 99%

The effects of coconut oil supplementation on the body composition and lipid profile of rats submitted to physical exercise

Resende

Félix

Soré

et al. 2016

An. Acad. Bras. Ciênc.

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This study aims to verify the effects of coconut oil supplementation (COS) in the body composition and lipid profi le of rats submitted to physical exercise. The animals (n=6 per group) were randomly assigned to: G1=Sedentary and Non-supplemented (Control Group), G2=Sedentary and Supplemented, G3=Exercised and Non-supplemented and G4=Exercised and Supplemented. The COS protocol used was 3 mL/Kg of body mass by gavage for 28 days. The physical exercise was the vertical jumping training for 28 days. It was determined the body mass parameters, Lee Index, blood glucose and lipid profi le. The COS did not interfere with body mass, but the lean body mass was lower in G3 compared to G2. The fi nal Lee Index classifi ed G1 and G2 as obese (>30g/cm). The lipid profi le showed total cholesterol was decreased in G3, LDL-c concentration was decreased in G2, triglycerides, VLDL-c and HDL-c concentrations were increased in G2 and G4 in relation to G1 and G3. The COS decreased LDL-c/HDL-c ratio. In conclusion, the COS associated or not to physical exercise worsen others lipid parameters, like triglycerides and VLDL-c level, showing the care with the use of lipid supplements.

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Section: Introductionmentioning

confidence: 99%

The effects of coconut oil supplementation on the body composition and lipid profile of rats submitted to physical exercise

Resende

Félix

Soré

et al. 2016

An. Acad. Bras. Ciênc.

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“…However, the antimicrobial activity of lauric acid against S. epidermidis is well studied, and the MIC was determined to be 3.9 g/ml (26). Multiple studies suggest that monolaurin has better antimicrobial properties than lauric acid (21,25,27). Therefore, the MIC of monolaurin against S. epidermidis can be expected to be lower than 3.9 g/ml.…”

Section: Discussionmentioning

confidence: 99%

Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections

Gil

Shuvaev

Frank-Kamenetskii

et al. 2017

Antimicrob Agents Chemother

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Novel approaches to the prevention of microbial infections after the insertion of orthopedic external fixators are in great demand because of the extremely high incidence rates of such infections, which can reach up to 100% with longer implant residence times. Monolaurin is an antimicrobial agent with a known safety record that is broadly used in the food and cosmetic industries; however, its use in antimicrobial coatings of medical devices has not been studied in much detail. Here, we report the use of monolaurin as an antibacterial coating on external fixators for the first time. Monolaurin-coated Kirschner wires (K-wires) showed excellent antibacterial properties against three different bacterial strains, i.e., methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and Staphylococcus epidermidis. Approximately 6.0-log reductions of both planktonic and adherent bacteria were achieved using monolaurin-coated K-wires, but monolaurin-coated K-wires did not show any observable cytotoxicity with mouse osteoblast cell cultures. Overall, monolaurin-coated K-wires could be promising as potent antimicrobial materials for orthopedic surgery.

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“…This compound is the main antiviral, antibacterial, substance found in human breast milk. Numerous bactericidal effects have been attributed to the activity of lauric acid and monolaurin [11]. This compound has been shown to be effective against Staphylococcus aureus, Mycobacterium terrae, Enterococcus faecalis, Listeria monocytogenes, Streptococcus agalactiae and several other groups of streptococci [12].…”

Section: Introductionmentioning

confidence: 99%

“…Some of the viruses inactivated by monolaurin include HIV, measles, Herpes simplex-1, vesicular stomatitis, the visna virus, and the cytomegalovirus [13]. Caprylic acid, capric acid and myristic acid can be virucidal and bactericidal as well [11].…”

Section: Introductionmentioning

confidence: 99%

“…Appreciable amounts of SCFA and MCFA (C4-C10) are present in milk fat, contributing up to 10 wt% of the fatty acid composition [20]. Coconut oil and certain coconut products contain approximately 50 wt% lauric acid and approximately 6-7 wt% capric acid [11]. Direct fractionation of triacylglycerols from samples such as butteroil has not yielded very good results of products highly enriched in SCFA and MCFA.…”

Section: Introductionmentioning

confidence: 99%

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Fractionation of Short and Medium Chain Fatty Acid Ethyl Esters from a Blend of Oils via Ethanolysis and Short‐Path Distillation

Vázquez

Akoh

2010

J Americ Oil Chem Soc

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The main objective of the present work was to obtain fractions enriched in short (SCFAEE) and medium chain (MCFAEE) fatty acid ethyl esters (FAEE) from a blend of oils. For this purpose, coconut oil and dairy fat were blended and a transesterification of this blend was performed in order to transform the triacylglycerols into their corresponding FAEE. A detailed study of fractionation conditions for FAEE was carried out using short-path distillation. Different conditions were explored such as feed rates and temperatures; operating conditions, such as successive steps or a single step. The composition and yield of SCFAEE and MCFAEE were determined under different distillation conditions. Optimal fractionation of the desired compounds was achieved. High purity of SCFAEE and MCFAEE (94 wt%) was attained with a yield of *50%. An increased yield of SCFAEE and MCFAEE was achieved (85%) with a purity of 83 wt%. A broad range of high value fractions was obtained depending on the conditions selected. The fractions we obtained can be used as starting materials for the production of functional lipids.

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A Review of Monolaurin and Lauric Acid:Natural Virucidal and Bactericidal Agents

Cited by 113 publications

References 12 publications

The effects of coconut oil supplementation on the body composition and lipid profile of rats submitted to physical exercise

The effects of coconut oil supplementation on the body composition and lipid profile of rats submitted to physical exercise

Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections

Fractionation of Short and Medium Chain Fatty Acid Ethyl Esters from a Blend of Oils via Ethanolysis and Short‐Path Distillation

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