A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

He, Ziliang; Hu, Yeye; Niu, Zhiqiang; Zhong, Kang; Liu, Tingwu; Yang, Meng; Ji, Lu; Hu, Weicheng

doi:10.1016/j.jep.2022.115865

Cited by 32 publications

(19 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The experimental and clinical findings have suggested that many of the beneficial effects on cutaneous repair process produced by C. asiatica are directly associated with their actions on the proliferative phase of the wound healing process, such as stimulation of fibronectin and collagen synthesis, maintenance of connective tissue and the strengthening of weakened veins [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Asiatic acid has been reported to possess wound healing activity by increasing collagen formation and angiogenesis.…”

Section: Centella Asiatica and Cutaneous Repair Processmentioning

confidence: 99%

“…Flavonoids, plant sterols, eugenol and pentacyclic triterpenoids are among the several interesting phytochemical constituents found in the C. asiatica [ 25 , 26 , 33 ]. Most of studies have reported the asiatic acid, as one of the main active constituents producing the wound healing activity of C. asiatica [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is absorbed in the jejunum and distributed in many tissues (e.g., plasma, brain, heart, liver, kidney, colon, and bladder) by binding with albumin and mainly metabolized in the intestine [ 33 ]. It is also known that the chemical modification of the asiatic acid’s backbone improved its bioavailability and biological activity [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. Asiatic acid is the most potent component of C. asiatica for induction of expression of TNFAIP6, a hyaladherin involved in extracellular matrix remodeling and modulation of inflammation, in human fibroblasts [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

et al. 2023

View full text Add to dashboard Cite

An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a promising strategy to obtain drugs therapeutically useful in the acute and chronic wound management. In this context, Centella asiatica (Apiaceae) has been used to treat a variety of skin diseases, such as leprosy, lupus, varicose ulcers, eczema and psoriasis, in Asiatic traditional medicine for thousands of years. Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration and wound repair process by promoting fibroblast proliferation and collagen synthesis. Preliminary findings have shown that the asiatic acid is one of the main active constituents of C. asiatica, directly associated with its healing activity. Thus, this study discusses aspects of the effects of Centella asiatica and its active component, asiatic acid, in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects that contribute to its therapeutic potential.

show abstract

Section: Centella Asiatica and Cutaneous Repair Processmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Plant secondary metabolites, produced as defense mechanisms against phytophagous insects, have been recognized as valuable pesticide candidates over the years. ,− Triterpenoid saponins, a large family of natural products found in numerous plants, , display various bioactivities including skin-protective, neuroprotective, antitumor, − anti-inflammatory, , cardiovascular-protective, pulmonary-protective, insecticidal, − molluscicidal activities, and so on . As one of the most enormous genera belonging to the Family Ranunculaceae, Clematis possesses 280–350 species and is widely distributed all over the world, especially in China (up to 147 species) .…”

Section: Introductionmentioning

confidence: 99%

Discovery of New Botanical Insecticides: Identification and Insecticidal Activity of Saponins from Clematis obscura Maxim and Insights into the Stress Response of Acyrthosiphon pisum Harris

Hao,

Qi,

Zhao

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

To discover new botanical products-based insecticide candidates, 14 triterpenoid saponins (1−14) including four new ones, obscurosides A-D (1−4), were isolated from Clematis obscura Maxim as potential agrochemicals against Acyrthosiphon pisum Harris and Plutella xylostella (L.). Compounds 1−3 were characterized by a rare ribose substitution at C-3, and 4 was a bidesmoside glycosylated at the rare C-23 and C-28 positions of the oleanane aglycone. Compounds 10 (median antifeeding concentration, AFC 50 = 1.10 mg/mL; half-lethal concentration, LC 50 = 1.21 mg/mL) and 13 (AFC 50 = 1.09 mg/mL, LC 50 = 1.37 mg/mL) showed significant insecticidal activities against third larvae of P. xylostella at 72 h. All saponins displayed antifeedant activities against A. pisum with the deterrence index of 0.20−1.00 at 400 μg/mL. Compound 8 showed optimal oral toxicity (LC 50 = 50.09 μg/mL) against A. pisum, followed by compounds 1, 5−7, 9, and 14 (LC 50 = 90.21−179.25 μg/mL) at 72 h. The shrinkage of the cuticle and the destruction of intestinal structures of microvilli, nucleus, endoplasmic reticulum, and mitochondria were toxic symptoms of 8-treated A. pisum. The significantly declined Chitinase activity in 8-treated A. pisum with an inhibition rate of 79.1% at LC 70 (70% lethal concentration) could be the main reason for its significant oral toxicities. Molecular docking revealed favorable affinities of compounds 1 and 8 with group I Chitinase Of ChtI (Group I Chitinase from Ostrinia furnacalis) through conventional hydrogen bonds and alkey/π-alkey interactions by different patterns. These results will provide valuable information for the development of novel botanical pesticides for the management of insect pests, especially against A. pisum.

show abstract

“…Gotu kola is a small herbaceous plant that has been traditionally used in traditional medicine systems in Asia for its potential health benefits. 69 The biological activities of AC are diverse and include anti-inflammatory, 70 antioxidant action, 71 stimulation of collagen, 72 and angiogenesis production. 73 AC has been utilized therapeutically to promote the healing of wounds and lessen the development of scar tissue.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Kumar,

Mahmood

et al. 2024

RSC Pharm.

View full text Add to dashboard Cite

show abstract

A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

Cited by 32 publications

References 119 publications

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

Discovery of New Botanical Insecticides: Identification and Insecticidal Activity of Saponins from Clematis obscura Maxim and Insights into the Stress Response of Acyrthosiphon pisum Harris

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Contact Info

Product

Resources

About