Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Kumar, Mohit; Kumar, Devesh; Mahmood, Syed; Singh, Varinder; Chopra, Shruti; Hilles, Ayah R.; Bhatia, Amit

doi:10.1039/d3pm00024a

Cited by 10 publications

(1 citation statement)

References 324 publications

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“…Chitosan films may be placed directly on the injury to treat wounds. They provide a barrier against infection and help wounds heal by keeping the area wet, encouraging cell proliferation and migration [100,101]. Chitosan hydrogels, which are three-dimensional networks of crosslinked chitosan molecules, readily absorb water.…”

Section: Wound Healing Activity Of Chitosanmentioning

confidence: 99%

Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Mawazi,

Kumar,

Ahmad

et al. 2024

Polymers

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Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse applications of chitosan and its derivatives in the antibacterial, anticancer, wound healing, and tissue engineering fields. In antibacterial applications, chitosan exhibits potent antimicrobial properties by disrupting microbial membranes and DNA, making it a promising natural preservative and agent against bacterial infections. Its role in cancer therapy involves the development of chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays a crucial role in wound healing by promoting cell proliferation, angiogenesis, and regulating inflammatory responses. Additionally, chitosan serves as a multifunctional scaffold in tissue engineering, facilitating the regeneration of diverse tissues such as cartilage, bone, and neural tissue by promoting cell adhesion and proliferation. The extensive range of applications for chitosan in pharmaceutical and biomedical sciences is not only highlighted by the comprehensive scope of this review, but it also establishes it as a fundamental component for forthcoming research in biomedicine.

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Section: Wound Healing Activity Of Chitosanmentioning

confidence: 99%

Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Mawazi,

Kumar,

Ahmad

et al. 2024

Polymers

Self Cite

View full text Add to dashboard Cite

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Chitosan‐Based Hydrogels as Antibacterial/Antioxidant/Anti‐Inflammation Multifunctional Dressings for Chronic Wound Healing

Xu,

Chang,

Xiong

et al. 2024

Adv Healthcare Materials

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Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult to heal, posing a serious threat to public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of chronic wounds and enhance cellular function holds great significance. Recently, chitosan has emerged as a promising biopolymer for wound healing due to its excellent biocompatibility, biodegradability, and versatile bioactivity. The aim of this review is to provide a comprehensive understanding of the mechanisms of delayed chronic wound healing and discuss the healing–promoting properties of chitosan and its derivatives, such as good biocompatibility, antibacterial activity, hemostatic capacity, and the ability to promote tissue regeneration. On this basis, the potential applications of chitosan‐based hydrogels are summarized in chronic wound healing, including providing a suitable microenvironment, eliminating bacterial infections, promoting hemostasis, inhibiting chronic inflammation, alleviating oxidative stress, and promoting tissue regeneration. In addition, the concerns and perspectives for the clinical application of chitosan‐based hydrogels are also discussed.

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AQbD enabled method development and quantification of asiaticoside in foam-based formulations

Kumar,

Pant,

Chopra

et al. 2024

Accred Qual Assur

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Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Abstract: The physical properties of asiaticoside (AC), such as its high molecular weight, poor water solubility, and low permeability, restrict its therapeutic benefits. AC-loaded nano-carriers overcome AC limitations in wound healing by enhancing delivery efficiency, stability, and safety.

Cited by 10 publications

References 324 publications

Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Chitosan‐Based Hydrogels as Antibacterial/Antioxidant/Anti‐Inflammation Multifunctional Dressings for Chronic Wound Healing

AQbD enabled method development and quantification of asiaticoside in foam-based formulations

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