A Review of Plants with Remarkable Hepatoprotective Activity

Meshack, Sanjana; Gupta, Suchita

doi:10.22270/jddt.v12i1.5283

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Similar results were observed in a study where M. pruriens reduced hepatocellular necrosis and prevented cellular infiltration and vacuolation in diabetic rats exposed to 200 mg/kg BW of M. pruriens for 28 days, which may be due to its rich antioxidant properties [ 53 ]. Alkaloids and saponins are reported to elicit hepatoprotective activity by inhibiting lipid peroxidation [ 54 , 55 ], thus stabilizing the hepatocellular membrane, preventing cell leakage, and increased hepatic regeneration.…”

Section: Discussionmentioning

confidence: 99%

Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induced testicular toxicity and hepato-renal histopathology in rats

Bairy

Raghavendra

2023

Vet World

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Background and Aim: A significant cause of arsenic poisoning is polluted groundwater. Arsenic poisoning results in the suppression of spermatogenesis and the liver and kidneys are vulnerable to the toxic effects as well. Mucuna pruriens has been identified to have fertility-enhancing and anti-lipid peroxidation properties. Based on these properties of M. pruriens, this study aimed to investigate the efficacy of M. pruriens seed extract in reducing sodium arsenite-induced testicular impairment and hepato-renal histopathology in rats. Materials and Methods: The study was divided into two groups; short-term (45 days) and long-term (90 days) treatment groups and each group was divided into nine subgroups. Subgroups 1 and 2 served as normal and N-acetyl cysteine (NAC) controls, respectively. Subgroups 3–9 received sodium arsenite in the drinking water (50 mg/L). Subgroup-4 received NAC (210 mg/kg body weight [BW]) orally once daily. Subgroups 5–7 received aqueous seed extract of M. pruriens (350, 530, and 700 mg/kg BW, respectively) orally once daily. Subgroups 8 and 9 received a combination of NAC and aqueous seed extract (350 and 530 mg/kg BW, respectively) orally once daily. Following the treatment, animals were sacrificed and sperm parameters and DNA damage were evaluated. Testis, liver, and kidneys were analyzed for histopathology. Results: Sodium arsenite-induced a significant reduction in sperm parameters and increase in the abnormal architecture of spermatozoa. Histology revealed tissue necrosis. The M. pruriens seed extract ameliorated the damaging effects of sodium arsenite with respect to tissue architecture and sperm parameters when coadministered. Conclusion: Mucuna pruriens has beneficial effects against the deleterious effects of sodium arsenite on various tissues. Thus, M. pruriens (530 and 700 mg/kg BW) supplementation would reduce the adverse changes observed with sodium arsenite exposure.

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Section: Discussionmentioning

confidence: 99%

Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induced testicular toxicity and hepato-renal histopathology in rats

Bairy

Raghavendra

2023

Vet World

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“…The antioxidant, anticancer, anti-inflammatory, anti-allergic, anti-aging, DNA-protective, antibacterial, and hepatoprotective properties of plants have been the subject of many research. [3][4][5][6][7] Determining the biological activity of plants is, therefore, crucial for their application as supplementary medicines in this setting. They have further pharmacological use as natural materials.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and oxidant status, DPPH activity, total phenolic and flavonoid contents of mountain tea (Sideritis libanotica subsp. kurdica (Bornm.) Hub.-Mor)

Uysal

Mohammed²,

Koçer

et al. 2023

International Journal of Chemistry and Technology

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Throughout history, people have found several uses for plants. Numerous research have demonstrated the widespread application of plants as a kind of supplementary therapy. Samples of Sideritis libanotica subsp. kurdica (Bornm.) Hub.-Mor, often known as mountain tea, were gathered in Iraq and analysed for their antioxidant and oxidant status, DPPH activity, total phenolic and total flavonoid contents. The plant's aerial parts were utilised for this purpose. A soxhlet was used to get the plant's ethanol extract. The levels of antioxidants and free radicals were measured by Rel assay kits. The ability to scavenge free radicals was evaluated using the DPPH technique. The total phenolic content was calculated using the Folin-Ciocalteu reagent. Aluminum chloride analysis was used to calculate the total flavonoid content. The results showed that the aerial parts of the plant had TAS values of 7.934±0.179 mmol/L, TOS values of 10.626±0.275 µmol/L, and OSI values of 0.134±0.001. The total phenolic and flavonoid contents were found to be 129.75±2.37 and 111.47±3.15 mg/g, respectively. Furthermore, DPPH activity at 2 mg/mL was calculated to be 75.15±1.45. S. libanotica subsp. kurdica has been found to have antioxidant activity and is thus a viable natural antioxidant source in this context.

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Green synthesis of silver nanoparticles via Taxus wallichiana Zucc. plant-derived Taxol: Novel utilization as anticancer, antioxidation, anti-inflammation, and antiurolithic potential

Bhusari

Sah

Lakkakula

et al. 2023

Green Processing and Synthesis

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Throughout history, the utilization of plant products as medicinal remedies has been widespread, with numerous modern drugs finding their origins in the plant kingdom. Taxol, derived from Taxus species, stands out as an exceptional and highly potent anticancer medication. In this study, we present a rapid one-pot synthesis method for silver nanoparticles (AgNPs) using the leaves of Taxus wallichiana Zucca in the presence of sunlight. The synthesized AgNPs were comprehensively characterized using X-ray diffraction, transmission electron microscopy, and HPLC Q-TOF. The AgNPs were further investigated for their antioxidative, anticancer, anti-inflammatory, and antiurolithi properties. The anticancer activity was assessed through a sulforhodamine B assay conducted on the MDA-MB-231 human breast carcinoma cell line and SiHa human cervical cancer cell line. The findings of this study reveal the impressive antioxidative, anticancer, anti-inflammatory, and antiurolithi characteristics exhibited by AgNPs synthesized from leaf extracts. This research highlights an environmentally friendly and cost-effective approach to producing AgNPs by utilizing plant extracts as reducing agents, underscoring the immense potential of natural resources in advancing nanotechnology and its applications.

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A Review of Plants with Remarkable Hepatoprotective Activity

Cited by 5 publications

References 23 publications

Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induced testicular toxicity and hepato-renal histopathology in rats

Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induced testicular toxicity and hepato-renal histopathology in rats

Antioxidant and oxidant status, DPPH activity, total phenolic and flavonoid contents of mountain tea (Sideritis libanotica subsp. kurdica (Bornm.) Hub.-Mor)

Green synthesis of silver nanoparticles via Taxus wallichiana Zucc. plant-derived Taxol: Novel utilization as anticancer, antioxidation, anti-inflammation, and antiurolithic potential

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