ORIGINAL RESEARCH ARTICLEProviding a polymeric device with antibacterial properties can be achieved by different routes, including the modification of the polymer structure. The incorporation of antimicrobials, or other molecules, into a polymer matrix by melt processing is a method that has been widely adopted in the recent past since it has the advantage of using equipment already commonly used to process thermoplastic materials (23)(24)(25)(26)(27)(28)(29)(30)(31)(32). This method also ensures large production volumes and solventless systems with obvious positive implications for environmental and economic factors. Nevertheless, the high temperatures involved in melt processing may lead to the melting and/or decomposition of the antimicrobial agent, with consequent deactivation. Thus, it is mandatory to know both the melt and decomposition temperatures of the biocide additives in order to avoid their degradation.In our previous works, we successfully prepared different antimicrobial polymeric systems by melt compounding (24)(25)(26)(27)(29)(30)(31)(32). In particular, we incorporated different antibacterial additives into an appropriate polymeric matrix, taking both the final application and the processing temperature of the polymeric sample into account when choosing the polymer-antibacterial pairing.Ciprofloxacin (CFX) is a wide-spectrum antibiotic belonging to the fluoroquinolone family. It is active against many strains of bacterial pathogens responsible for urinary tract, respiratory, abdominal and gastrointestinal infections, including both . Its melting temperature is about 268°C (37).