2017
DOI: 10.1038/pcan.2017.19
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A review of pomegranate in prostate cancer

Abstract: BackgroundPreclinical studies showing that pomegranate juice and its components inhibit prostate cancer led to multiple clinical trials to determine whether pomegranate products could slow the growth of prostate cancer. This review summarizes the preclinical data and discusses the results of the clinical trials.MethodsTrials targeted patients on active surveillance, neoadjuvant patients, patients with biochemical recurrence (BCR) following local therapy for prostate cancer, and patients with metastatic castrat… Show more

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Cited by 41 publications
(24 citation statements)
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“…Similar results with muscadine grape skin extract have evidenced no benefit on recurrent prostate cancer patients in spite of urolithin A increase [68]. Nonetheless, authors [67] have noted in a specific group of patients (named AA genotype), which has been previously associated with more hostile prostate cancer and more sensitivity to antioxidants, a significant increase in a prostate-specific antigen doubling times (PSADT), an antigen that is claimed to slow tumor growth.…”
Section: Chemoprevention Of Cancersmentioning
confidence: 69%
See 1 more Smart Citation
“…Similar results with muscadine grape skin extract have evidenced no benefit on recurrent prostate cancer patients in spite of urolithin A increase [68]. Nonetheless, authors [67] have noted in a specific group of patients (named AA genotype), which has been previously associated with more hostile prostate cancer and more sensitivity to antioxidants, a significant increase in a prostate-specific antigen doubling times (PSADT), an antigen that is claimed to slow tumor growth.…”
Section: Chemoprevention Of Cancersmentioning
confidence: 69%
“…A recent review compiles the data of clinical trial studies after consumption of pomegranate juice or extracts and discusses whether urolithin could inhibit or slow the growth of prostate cancer in patients. The authors reported a significant increase in urolithin A in prostate but a nonsignificant reduction in 8-hydroxy-2-deoxyguanosine, a marker of oxidation in cancer tissue, for neoadjuvant patients subjected to radical prostatectomy after pomegranate intake (1200 mg polyphenols/day) compared with placebo in a large trial (4 weeks, n = 33) [67]. Similar results with muscadine grape skin extract have evidenced no benefit on recurrent prostate cancer patients in spite of urolithin A increase [68].…”
Section: Chemoprevention Of Cancersmentioning
confidence: 99%
“…A high level of ROS from radiation could induce MnSOD and Prx6 expression as an adaptive response to protect radiation-mediated oxidative stress insult. In addition, increases of MnSOD and Prx6 have been associated with biochemical recurrence in prostate cancer patients after radical prostatectomy (275) as well as with fetal esophageal development (124,257). Thus, these two APs could be used as markers for the radioresistant phenotype in cancers.…”
Section: Radiation-resistant Cancersmentioning
confidence: 99%
“…In addition, pomegranate extract has been shown to exhibit an inhibitory effect on the NF-κB inflammatory pathway, thus enabling the extract to demonstrate its pro-apoptotic effect [136]. Increased NF-κB activity has been shown to be an important predictor of the biochemical recurrence of PCa and hence the transition from androgen dependence to independence following local therapy [136,137,138].…”
Section: Polyphenols and Prostate Cancermentioning
confidence: 99%