A review of potential anti-cancer properties of some selected medicinal plants grown in Iran

Hamedi, Azadeh; Bayat, Maryam; Asemani, Yahya; Amirghofran, Zahra

doi:10.1016/j.hermed.2022.100557

Cited by 23 publications

(13 citation statements)

References 254 publications

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“…The use of medicinal herbs for cancer treatment alongside conventional therapies has received increasing recognition due to their anticancer potential [3]. The benefits of medicinal herbs in tumor treatment have been attributed to their phytochemical content [4][5][6] which include flavonoids, phenolic acids, and essential oils. Such bioactive compounds have been found to be potent immunomodulators, with the potential to minimize negative impacts from cancer treatment [2].…”

Section: Introductionmentioning

confidence: 99%

GC-MS analysis and invitro cytotoxic activity of Ocimum basilicum (Lamiaceae) volatile oil and active fraction composed majorly of estragole

Imade¹,

Ayinde²

2022

J. Pharm Bio.

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Ocimum basilicum leaves contain some bioactive compounds and this study was designed to evaluate the cytotoxic efficacy of its volatile oil and fractions. Preliminary screening of the oil obtained by hydrodistillation was carried out using bench-top assay methods employing tadpoles of Raniceps ranninus (10-40 μg/mL), nauplii of Artemia salina (10-1000 μg/mL) and radicles of Sorghum bicolor seeds (1-30 mg/mL). Application of column chromatography and preparative TLC on the oil resulted in fractions that were tested alongside the oil on breast (AU 565) and cervical (HeLa) cancer cell lines at 50 μg/mL. GCMS analysis was carried out on the oil and the most active fraction. A concentration dependent activity was observed in the preliminary screening with the bench-top assays. The active fraction produced greater growth inhibition of the radicle of S. bicolor seeds than the oil. Inhibitions of -1.02 and +23.02 % were realized against AU 565 and HeLa cell lines respectively with the oil, and these were increased to +33.19 and +89.3 % inhibitions respectively with the active fraction. GCMS results revealed the presence of estragole (88.61 %) as being most abundant in the fraction. This result shows the cytotoxic potential of O. basilicum volatile oil, which was increased in its estragole-containing fraction.

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Section: Introductionmentioning

confidence: 99%

GC-MS analysis and invitro cytotoxic activity of Ocimum basilicum (Lamiaceae) volatile oil and active fraction composed majorly of estragole

Imade¹,

Ayinde²

2022

J. Pharm Bio.

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“…In contrast, bioactive phytochemicals or plant-derived compounds have significantly positive outcomes in several clinical trials [ 35 ]. Several well-known phytochemicals have been discovered to possess anticancer characteristics in colorectal, prostate, breast, and glioblastomas [ 36 , 37 ]. Phytochemicals possessed potential anti-proliferative effects in cancer tissues via modulating several of the cancer’s cellular signaling mechanisms [ 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

Biswas¹,

Bibi

Yousafi

et al. 2023

Molecules

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An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several transcriptome servers were used to measure the differential expression of the targeted MDM2 gene and search mutations and copy number variations. GENT2, Gene Expression Profiling Interactive Analysis, Onco-Lnc, and PrognoScan were used to figure out the survival rate of LGG cancer patients. The protein–protein interaction networks between MDM2 gene and its co-expressed genes were constructed by Gene-MANIA tool. Identified bioactive phytochemicals were evaluated through molecular docking using Schrödinger Suite Software, with the MDM2 (PDB ID: 1RV1) target. Protein–ligand interactions were observed with key residues of the macromolecular target. A molecular dynamics simulation of the novel bioactive compounds with the targeted protein was performed. Phytochemicals targeting MDM2 protein, such as Taxifolin and (-)-Epicatechin, have been shown with more highly stable results as compared to the control drug, and hence, concluded that phytochemicals with bioactive potential might be alternative therapeutic options for the management of LGG patients. Our once informatics-based designed pipeline has indicated that the MDM2 gene may have been a predictive biomarker for LGG cancer and selected phytochemicals possessed outstanding interaction results within the macromolecular target’s active site after utilizing in silico approaches. In vitro and in vivo experiments are recommended to confirm these outcomes.

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“…The former plays the roles in color, astringency, and oxidative stability in plants, and the latter has the roles in unique flavor characteristics to each flower and foods (de Morais et al 2022 ). Secondary metabolites with a variety of biological activity and treatment of various diseases are classified into essential oils, flavonoids, glycosides, alkaloids, tannins, resins, saponins, and phytosterols (Hamedi et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Foliar Application of Iron Oxide Nanoparticles Promotes Growth, Mineral Contents, and Medicinal Qualities of Solidago virgaurea L

Ahmed

Shafiei-Masouleh

Mohsin

et al. 2023

J Soil Sci Plant Nutr

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Goldenrod ( Solidago virgaurea L.) is considered for their medicinal properties for humans. These properties are attributed to some volatile compounds that can be extracted from above- and underground organs of plants. More ingredients of medicinal plants are undoubtedly considered by herbal medicine activists. The study aimed to promote Solidago yield and quality under foliar application of Fe 2 O 3 nanoparticles that can be considered as a safe and healthy fertilizer on the basis of US Food and Drug Administration (FDA) regulatory process about color additives. The experiment was performed with concentrations of Fe 2 O 3 nanoparticles (0, 0.5, or 1 mg L −1 ) and foliar application times (1, 2, 3, 4, or 5 times) on 4- to 5-leaf plants of Solidago virgaurea . Results showed that 4 times foliar application of 1 mg L −1 caused the best plant growth and mineral element contents (nitrogen, phosphorous, potassium, copper, and zinc) except for Fe content that the more the times of foliar application, the more the Fe content increased. However, the flavonoid (rutin and quercetin) and essential oils (caryophyllene, alpha-pinene, camphene, limonene, linalool, myrcene, and terpinene) as biochemical and medicinal qualities of the treated plants were remarkably promoted when 1 mg L −1 of nanoparticles was sprayed 5 times. Furthermore, the more the element contents, the more the ingredients. Finally, based on the goals of herbal medicine activists for the production of the essence, extract, or herb, both 5 and 4 times of foliar applications of ferric oxide nanoparticles are safe and may be economic and recommendable.

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A review of potential anti-cancer properties of some selected medicinal plants grown in Iran

Cited by 23 publications

References 254 publications

GC-MS analysis and invitro cytotoxic activity of Ocimum basilicum (Lamiaceae) volatile oil and active fraction composed majorly of estragole

GC-MS analysis and invitro cytotoxic activity of Ocimum basilicum (Lamiaceae) volatile oil and active fraction composed majorly of estragole

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

Foliar Application of Iron Oxide Nanoparticles Promotes Growth, Mineral Contents, and Medicinal Qualities of Solidago virgaurea L

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