A Review of Select Recent Patents on Novel Nanocarriers

Grill, Alexander E; Johnston, Neil; Sadhukha, Tanmoy; Panyam, Jayanth

doi:10.2174/187221109788452276

Cited by 30 publications

(13 citation statements)

References 32 publications

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“…This can increase the accumulation of the encapsulated product at the desired site, which will enhance its efficacy [59]. This introduces another face of the drug discovery coin that relies on the development of novel biotherapeutics.…”

Section: Impact Of Drug-delivery Systems In Biotherapeutics Developmentsmentioning

confidence: 99%

Delivering Natural Products and Biotherapeutics to Improve Drug Efficacy

et al. 2017

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Due to the increasing problem of drug resistance, new and improved medicines are required. Natural products and biotherapeutics offer a vast resource for new drugs; however, challenges, including the cost and time taken for traditional drug discovery processes and the subsequent lack of investment from the pharmaceutical industry, are associated with these areas. New techniques are producing compounds with appropriate activity at a faster rate. While the formulation of these combined with drug-delivery systems offers a promising approach for expanding the drug developments available to modern medicine. Here, various classes of drug-delivery systems are described and the advantages they bring to small molecule and biotherapeutic targeting are highlighted. This is an attractive approach to the pharmaceutical industry and the rising trend in research in this area is examined in brief. New medicines are constantly being developed or repurposed, aimed at curing or preventing diseases or conditions where therapeutic product availability is lacking, or to reduce side effects, improve quality of life, reduce the burden on the cost of healthcare systems, while significantly extending patients' lives. However, drug discovery, research and development (R&D) can be an extensive process lasting over 7-10 years, with an average cost of $2.6 billion for each successful drug that reaches the market [1]. These substantial cost and time factors originate from the scientific, technical and regulatory challenges that are needed to fully understand the drug mechanisms of action and physiological interactions for complex diseases at molecular level. Achieving viable commercial success subsequently

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Section: Impact Of Drug-delivery Systems In Biotherapeutics Developmentsmentioning

confidence: 99%

Delivering Natural Products and Biotherapeutics to Improve Drug Efficacy

et al. 2017

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“…[9][10][11][12] There are many of the herbal products and their derived constituents present in the market are: Lovastatin (anticholesterolemic), [13] paclitaxol, doxorubicin (both anticancer drugs), cyclosporine-A and tacrolimus (both immunosuppressive), [14,15] erythromycin, streptomycin, rafamycin (all antibiotics), and amphotericin-B (fungicidal). Actually, with respect to the conventional pharmaceuticals, these drugs have their existence from natural remedies.…”

Section: Review Articlementioning

confidence: 99%

Untitled

Tapadiya¹

2017

IJGP

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Natural herbs are moving from fringe to mainstream use with a increase number of population-seeking remedies and health approaches free from hazardous side effects caused by laboratory synthesize chemicals. Recently, focus has been given to utilize eco-friendly and bio-friendly natural-based products for the prevention and cure of diseases. It is documented that 80% of the world's population has belief in natural medicine, particularly plant-based drugs for their primary healthcare. Herbal drug generally introduce in the market in traditional dosage form but now different scientific approaches are being developed these days to deliver herbal medicines due to their poor rate of absorption and target specific approach. Novel drug delivery systems including nanoparticles have been developed for the effective delivery of herbal drugs. Nanoparticulate formulations such as liposomes, polymeric nanoparticles, microemulsions, proliposomes, and solid lipid nanoparticles present potential to deliver herbal medicines effectively. Because of nanotechnology, the use of herbal drug is greatly increased in recent years. In this article, we are try to elaborating the role of nanotechnology which increases the potential as well as sale of herbal drugs in global world.

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“…A few of those advantages are well known and have been demonstrated in previous studies: a wide variety of drugs, from those that are extremely hydrophobic to those that are highly hydrophilic (Kennedy et al 2010), can be encapsulated in PLGA nanoparticles, the drug release rates can be modified to particular applications (Grill et al 2009), and loading and size can be easily manipulated to provide further control over drug delivery (Jeong et al 2000). However, it has been established as being surprisingly difficult to produce surface-modified, drug-encapsulated PLGA particles.…”

Section: Introductionmentioning

confidence: 95%