A review of studies on bioactive compounds isolated from Sri Lankan flora

Siriwardhana, Asitha; Wijesundara, Siril; Karunaratne, Veranja

doi:10.4038/jnsfsr.v43i1.7912

Cited by 4 publications

(4 citation statements)

References 88 publications

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“…In plants, seselin has inhibitory activity on both indole acetic acid oxidase and peroxidase enzyme systems (Goren and Tomer, 1971). Seselin is effective against blowfly larvae (and its effects on the feeding and development of Lucilia cuprina larvae) and selectively activates some yeast strains (Siriwardhana et al ., 2015). It also has anti‐inflammatory (Garcia‐Argaez et al ., 2006), and antinociceptive (Lima et al ., 2006) properties.…”

Section: Introductionmentioning

confidence: 99%

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages

Sun

Song

et al. 2018

British J Pharmacology

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Background and Purpose Sepsis is a serious clinical condition with a high mortality rate. Anti inflammatory agents have been found to be beneficial for the treatment of sepsis. Here, we have evaluated the anti‐inflammatory activity of seselin in models of sepsis and investigated the underlying molecular mechanism(s). Experimental Approach In vivo therapeutic effects of seselin was evaluated in two models of sepsis, caecal ligation and puncture or injection of LPS, in C57BL/6 mice. In vitro, anti‐inflammatory activity of seselin was assessed with macrophages stimulated with LPS and IFN‐γ. Anti inflammatory actions were analysed with immunohistochemical methods, ELISA and Western blotting. Flow cytometry was used to assess markers of macrophage phenotype (pro‐ or anti‐inflammatory). Other methods used included co‐immunoprecipitation, cellular thermal shift assay and molecular docking. Key Results In vivo, seselin clearly ameliorated sepsis induced by caecal ligation and puncture. In lung tissue from septic mice and in cultured macrophages, seselin down‐regulated levels of proinflammatory factors and activity of STAT1 and p65, the master signal pathway molecules for polarization of macrophages into the proinflammatory phenotype. Importantly, adoptive transfer of bone marrow‐derived macrophages, pretreated with seselin, lowered systemic proinflammatory factors in mice challenged with LPS. The underlying mechanism was that seselin targeted Jak2 to block interaction with IFNγ receptors and downstream STAT1. Conclusions and Implications Seselin exhibited anti‐inflammatory activity through its action on Jak2. These results indicated a possible application of seselin to the treatment of inflammatory disease via blocking the development of the proinflammatory phenotype of macrophages.

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Section: Introductionmentioning

confidence: 99%

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages

Sun

Song

et al. 2018

British J Pharmacology

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“…Although developing countries have great potential to utilize these resources sustainably to reach the needs of herbal cosmeceutical manufactures, only limited number of herbal cosmeceuticals produced can reach the global market mainly due to lack of systematic research published in peer review journals, inadequate knowledge of their mode of action, poor understanding on potential adverse reactions, and poor networking with PPP etc. (Siriwardhana et al, 2015). Hence there is an urgent need to improve the standard and safety of the herbal cosmeceutical industry in developing countries.…”

Section: Herbal Cosmeceutical Production In Developing Countriesmentioning

confidence: 99%

Herbal cosmeceutical production in developing countries

Paranagama

2022

Ceylon J. Sci.

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“…They are chiefly in vegetables, fruits and whole grains, and beneficial to health in addition to the basic nutritional value. They are molecules with therapeutic potential and influence on calory intake, while reducing oxidative stress, pro-inflammatory state and disorders of metabolism [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bioactive compound content, in-vitro antioxidant and anti-inflammatory effects of ethanol extract of the seed of Cucumis metuliferus fruit

Ani¹,

Achikanu²,

Asogwa³

2022

GSC Biol. and Pharm. Sci.

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Cucumis metuliferus commonly called Kiwano is a well-known plant in the middle belt area of Nigeria. It is consumed for nutritional and medicinal purposes. This study evaluated the bioactive compound content, In-vitro antioxidant and anti-inflammatory properties of ethanol extract of the seed of Cucumis metuliferus fruit. The antioxidant properties were evaluated using DPPH (2, 2 diphenyl-1-picrylhydrazyl) radical, iron reducing power and inhibition of lipid peroxidation tests. Ascorbic acid served as standard. The anti-inflammatory activity at concentration of 200-1000 µg/ml was measured In-vitro using anti-proteinase activity, membrane stabilization and inhibition of albumin denaturation assay systems. Aspirin and diclofenac were used as reference drugs. The bioactive compounds evaluated were phenol, flavonoid, beta carotene, lycopene and ascorbic acid. From the result, the seed extract contains phenol (149.40±9.93 mgGAE/g), flavonoids (97.84±2.84 mgCE/g), beta carotene (0.110±0.001 mg/g), lycopene (0.085±0.001 mg/g) and ascorbic acid (0.190±0.028 mgAA/g). In the antioxidant assays, the antioxidant activities were dependent on the concentration. At lower concentrations, the seed extract displayed higher activity in all the assays compared with the standard. The DPPH scavenging and lipid inhibition abilities of the seed were more potent with lower IC50 while the reductive potential of the standard was better. From the anti-inflammatory assays, the seed extract exhibited anti-proteinase activity of 0-8.78%, membrane stabilization (inhibition of heat-induced haemolysis) activity of 5.13-20.51% and percent inhibition of albumin denaturation of 0.78-16.15%. These results showed that ethanol extract of Cucumis metuliferus seed contains bioactive compounds which are beneficial to health and possess antioxidant and anti-inflammatory abilities.

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A review of studies on bioactive compounds isolated from Sri Lankan flora

Cited by 4 publications

References 88 publications

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages

Herbal cosmeceutical production in developing countries

Evaluation of bioactive compound content, in-vitro antioxidant and anti-inflammatory effects of ethanol extract of the seed of Cucumis metuliferus fruit

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