A review of synthesis, fabrication, and emerging biomedical applications of metal-organic frameworks

Haider, Junaid; Shahzadi, Anum; Akbar, Muhammad Usama; Hafeez, Izan; Shahzadi, Iram; Khalid, Ayesha; Ashfaq, Atif; Ahmad, Shakil; Dilpazir, S.; Imran, Muhammad; Ikram, Muhammad; Ali, Ghafar; Khan, Matiullah; Khan, Qasim; Maqbool, Muhammad

doi:10.1016/j.bioadv.2022.213049

Cited by 30 publications

(24 citation statements)

References 286 publications

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“…Therefore, electric ovens can generally be used to provide energy, which can controllably increase the temperature within a certain range, greatly improving the rate of MOF formation. 87 MOFs can also be obtained at low temperatures, but they often require longer reaction times. 88 The filling degree is also an important factor, which refers to the volume fraction of the reaction mixture in the enclosed reactor space.…”

Section: The Synthesis Of Mofs Used In Stimuli-responsive Drug Deliverymentioning

confidence: 99%

“…141 Specifically, ultrasound can clean the surface of MOFs, causing the formed bonds to break again and re-exposing metal sites. 87 This action makes it widely used in the synthesis of adsorbents. Lee et al utilized sonochemical synthesis to fabricate MIL-53 with a hexagonal biconical shape for adsorbing methyl orange in aqueous solution.…”

Section: The Synthesis Of Mofs Used In Stimuli-responsive Drug Deliverymentioning

confidence: 99%

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Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

Xing,

Xu,

Zhou

et al. 2024

Nanoscale

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Section: The Synthesis Of Mofs Used In Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Section: The Synthesis Of Mofs Used In Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

Xing,

Xu,

Zhou

et al. 2024

Nanoscale

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“…The incorporation of PSs into the pores of MOFs prevented the aggregation and self-quenching and enabled the facile release of ROS via the porous channels and rigid frameworks. [141,142] Molecular oxygen is an important microenvironmental condition for the effective bactericidal activity of PDT, and the hypoxic microenvironment inevitably further impedes this oxygen consuming process. Thus, the PDT effect is often compromised in diabetic wounds.…”

Section: Pdtmentioning

confidence: 99%

“…The incorporation of PSs into the pores of MOFs prevented the aggregation and self‐quenching and enabled the facile release of ROS via the porous channels and rigid frameworks. [ 141,142 ]…”

Section: Sensitive Agents In Dfu Antibacterial Therapymentioning

confidence: 99%

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy

Jing

et al. 2023

Adv Healthcare Materials

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Diabetic foot ulcer (DFU), a common complication of diabetes, has become a great burden to both patients and the society. The delayed wound closure of ulcer sites resulting from vascular damage and neutrophil dysfunction facilitates bacterial infection. Once drug resistance occurs or bacterial biofilm is formed, conventional therapy tends to fail and amputation is unavoidable. Therefore, effective antibacterial treatment beyond antibiotics is of utmost importance to accelerate the wound healing process and prevent amputation. Considering the complexity of multidrug resistance, biofilm formation, and special microenvironments (such as hyperglycemia, hypoxia, and abnormal pH value) at the infected site of DFU, several antibacterial agents and different mechanisms have been explored to achieve the desired outcome. The present review focuses on the recent progress of antibacterial treatments, including metal‐based medications, natural and synthesized antimicrobial peptides, antibacterial polymers, and sensitizer‐based therapy. This review provides a valuable reference for the innovation of antibacterial material design for DFU therapy.

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“…They present structural flexibility, large surface areas, and pore sizes that can be tailored by a combination of metals, ligands, and synthesis conditions for a given application [ 116 ]. Numerous applications in many fields are being developed, such as gas storage [ 117 ], separation [ 118 ], chemical sensing [ 119 ], catalysis [ 120 ], and potential biomedical applications, including drug storage and delivery [ 121 , 122 ], biomedical gas storage [ 123 ], biosensing [ 124 , 125 ], or molecular imaging [ 126 ]. Figure 3 describes a morphological structure of MIL100 acquired by transmission electronic microscopy and illustrates some skin applications of metal–organic frameworks (MOFs).…”

Section: Metal-organic Framework As An Integrative Tool For Skin Trea...mentioning

confidence: 99%

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

et al. 2022

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Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.

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A review of synthesis, fabrication, and emerging biomedical applications of metal-organic frameworks

Cited by 30 publications

References 286 publications

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

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