A review of synthesis methods, properties and use of monetite cements as filler for bone defects

Motameni, Ali; Alshemary, Ammar Z.; Evis, Zafer

doi:10.1016/j.ceramint.2021.01.240

Cited by 27 publications

(20 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bone cements are usually divided into acrylic and phosphate-based cements [ 1 , 2 , 3 , 4 ]. Polymethyl methacrylate (PMMA), commonly known as bone cement, is widely used for implant fixation in various orthopedic and trauma surgery.…”

Section: Introductionmentioning

confidence: 99%

“…Adhesion improvement of 50% at the PMMA bone cement-titanium implant interface was obtained using atmospheric pressure plasma polymerization [ 6 ]. As concerns the phosphate-based cements, which usually are applied as bone-substitute materials, recently the brushite-based and monetite-based cements [ 1 , 7 , 8 ], those based on phosphate with bioactive ions, like Mg, Sr, Zn, Mn, Cu, Li, Co, Ag, [ 9 ], and silicate bone cements were proposed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

View full text Add to dashboard Cite

Cemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag, Cu with particles size in a range of 10–30 nm (Cu10) and 70–100 nm (Cu70), AgCu, and Ni were added to PMMA cement. Their influence on compression strength, wettability, and antibacterial properties of cement was assessed. The surface topography of samples was examined with biological and scanning electron microscopy. The mechanical properties were determined by compression tests. A contact angle was observed with a goniometer. The biological tests included an assessment of cytotoxicity (XTT test on human cells Saos-2 line) and bacteria viability exposure (6 months). The cements with Ag and Cu nanopowders were free of bacteria. For AgCu and Ni nanoparticles, the bacterial solution became denser over time and, after 6 months, the bacteria clustered into conglomerates, creating a biofilm. All metal powders in their native form in direct contact reduce the number of eukaryotic cells. Cell viability is the least limited by Ag and Cu particles of smaller size. All samples demonstrated hydrophobic nature in the wettability test. The mechanical strength was not significantly affected by the additions of metal powders. The nanometal particles incorporated in PMMA-based bone cement can introduce long-term resistance against bacteria, not resulting in any serious deterioration of compression strength.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 22 − 24 In addition, some other forms of doped apatite, such as fluor-carbonate hydroxyapatite, are found in fish enameloids. 25 Other biologically relevant CPCs are amorphous calcium phosphate (ACP), 26 , 27 monetite (dibasic calcium phosphate anhydrate, DCPA; CaHPO 4 ), 28 , 29 brushite (dibasic calcium phosphate dihydrate, DCPD; CaHPO 4 .2H 2 O), 30 octacalcium phosphate (OCP); Ca 8 H 2 (PO 4 ) 6 .H 2 O), 31 calcium pyrophosphate; Ca 2 P 2 O 7 ), 32 α-tricalcium phosphate (α-TCP), 33 β-tricalcium phosphate (β-TCP; Ca 3 (PO 4 ) 2 ), 34 and tetracalcium phosphate; Ca 4 (PO 4 ) 2 O). 35 Nevertheless, HA is not a resorbable form of CPC because the resorptive capacity of CPCs increases with their reduced crystallinity, such that ACP ≫ brushite > monetite > OCP > α-TCP ≫ β-TCP > HA.…”

Section: Introductionmentioning

confidence: 99%

Probing the Structure, Cytocompatibility, and Antimicrobial Efficacy of Silver-, Strontium-, and Zinc-Doped Monetite

Adawy

Dı́az

2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Calcium phosphate phases are among the most widely accepted compounds for biomaterial applications, of which the resorbable phases have gained particular attention in recent years. Brushite and its anhydrous form monetite are among the most interesting resorbable calcium phosphate phases that can be applied as cements and for in situ fabrication of three-dimensional (3D) implants. Of these two dicalcium phosphate compounds, monetite is more stable and undergoes slower degradation than brushite. The purpose of the current study is to synthesize and dope monetite with the antimicrobial elements silver and zinc and the osteoinductive element strontium and investigate the possible structural variations as well as their biocompatibility and antimicrobial effectiveness. For this, powder X-ray diffraction (PXRD), energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and cryo-transmission electron microscopy (cryo-TEM) were used to thoroughly study the synthesized structures. Moreover, the ASTM E-2149-01 protocol and a cell proliferation assay were used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and the cytocompatibility of the different phases with the Soas-2 cell line, respectively. The results confirm the successful synthesis and doping procedures, such that zinc was the most incorporated element into the monetite phase and strontium was the least incorporated element. The microbiological studies revealed that silver is a very effective antimicrobial agent at low concentrations but unsuitable at high concentrations because its cytotoxicity would prevail. On the other hand, doping the compounds with zinc led to a reasonable antimicrobial activity without compromising the biocompatibility to obviously high concentrations. The study also highlights that strontium, widely known for its osteoinductivity, bears an antimicrobial effect at high concentrations. The generated doped compounds could be beneficial for prospective studies as bone cements or for scaffold biomaterial applications.

show abstract

“…On the contrary, working at pH = 9 at 50°C and 25°C induced the selective formation of brushite or monetite (also with the presence of some impurities) respectively, that, in this context, have to be considered as undesired products. Nevertheless, these minerals are used in biomedicine for orthopedic and dental applications, such as bone regeneration, as well as for other biotechnological uses (drug delivery, cancer therapy and biosensing) [58, 59,60]. Therefore, the development of a new procedure for the synthesis of these nanoparticles based on the improvement of the present results could be an interesting subject for further studies.…”

Section: Characterisation Of Productsmentioning

confidence: 98%

Innovative nanomaterials for bone remains consolidation: performance evaluation and impact on 14C dating and on palaeogenetic analysis

Porpora

Zaro

Liccioli

et al. 2022

Preprint

View full text Add to dashboard Cite

An innovative protocol for the consolidation of ancient bone remains based on the use of nanometric hydroxyapatite (HAP) was set up and tested through a multidisciplinary approach. A new protocol for the synthesis of HAP nanoparticles was developed, and the composition of the obtained nanomaterial were investigated through Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD); sizes, shape and morphology of the synthesized particles were studied by Scanning Electron Microscopy (SEM). The consolidation performance was evaluated by testing the new nanomaterial on degraded ancient bone findings. An increase of the mineral density and of the micro-hardness of the bone were observed. The new consolidation method was also tested to assess possible effects on the palaeogenetic analysis and radiocarbon dating on the treated bones. The consolidation treatment has no substantial impact on the genetic characterisation of the skeletal remains and does not introduce any contaminations that could affect radiocarbon dating. This consolidation procedure represents a more compatible conservation tool with respect to traditional procedures: it has been shown that the treatment is effective, easily-applicable and not detrimental for 14C dating and palaeogenetic analysis.

show abstract

A review of synthesis methods, properties and use of monetite cements as filler for bone defects

Cited by 27 publications

References 114 publications

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Probing the Structure, Cytocompatibility, and Antimicrobial Efficacy of Silver-, Strontium-, and Zinc-Doped Monetite

Innovative nanomaterials for bone remains consolidation: performance evaluation and impact on 14C dating and on palaeogenetic analysis

Contact Info

Product

Resources

About