A review of the burden and management of mild asthma in adults — Implications for clinical practice

Abstract

A review of the burden and management of mild asthma in adults A review of the burden and management of mild asthma in adults A review of the burden and management of mild asthma in adults A review of the burden and management of mild asthma in adults-implications for clinical practice implications for clinical practice implications for clinical practice implications for clinical practice Running head: Mild asthma in adults-management considerations

Association between Interleukin-4-590C>T Polymorphism and the Susceptibility to Asthma: A Meta-Analysis of Case-Control Study

“…However, it does not fully comply with the classical Mendelian inheritance law, which is often caused by the interaction of multiple genetic and environmental factors and other susceptibility factors [ 8 – 10 ]. Most studies have shown that cytokines affect the type and duration of inflammatory response in patients with asthma caused by various causes and play an important role in the transmission between various inflammatory cells [ 5 – 7 ]. Because of various external reasons, the inflammatory response with different inflammatory mediators interacted with each other to increase the reactivity of the airway and produced inflammation and aggravation in the airway, leading to the occurrence of asthma [ 3 , 7 – 9 ].…”

“…The incidence of asthma varies between different regions and countries. Generally, in developed countries and urban areas where economic development is relatively fast, environmental pollution and other factors have led to higher incidence compared with developing countries [ 5 ]. Numerous studies have shown that environmental factors could cause asthma symptoms by affecting the patient's gene expression, which in turn affected its immune response to various inhalants [ 6 – 8 ].…”

Pharmacology Versus Convenience: A Benefit/Risk Analysis of Regular Maintenance Versus Infrequent or As-Needed Inhaled Corticosteroid Use in Mild Asthma

“…All ICS molecules demonstrated effective bronchoprotection over the whole dosing period under simulations of regular daily maintenance dosing with 100% adherence. In real life, however, poor adherence with regular daily maintenance therapies is often reported in asthma, with mean levels ranging between 22 and 70% [7][8][9][10][11][12][13]. Poor adherence is a key driver in determining the type of treatment approach in patients with mild asthma with ICS/formoterol as-needed being recommended in cases of poor adherence [1].…”

“…ICS also play an important role in preventing asthma deaths [5,6]. However, adherence to ICS is often poor with reported mean levels of adherence ranging from 22 to 70% [7][8][9][10][11][12][13], and mild asthma is particularly associated with poor adherence [10]. The Global Initiative for Asthma (GINA) options for management of mild asthma include regular daily low-dose ICS plus as-needed (PRN) shortacting beta agonist (SABA) or ICS/formoterol asneeded without regular ICS use [1].…”

Significant miR-145-a genotypes to serve as asthma predictors

“…The incidence of asthma varies among different areas in the world. Generally, in developed countries, more environmental exposures such as smog, air particles and other factors, usually result in a signi cantly higher incidence of asthma compared with those in developing countries [3]. Previous studies have found that the occurrence of asthma has strong genetic characteristics, with a heritability of up to 60-80% [4][5][6]; however, those genomic factors contributing to asthma are largely unknown and still under investigation.…”