2021
DOI: 10.12659/msm.930097
|View full text |Cite
|
Sign up to set email alerts
|

A Review of the Current Practice of Diagnosis and Treatment of Idiopathic Membranous Nephropathy in China

Abstract: Idiopathic membranous nephropathy (IMN), a common pathological type of nephrotic syndrome, is one of the main causes of kidney failure. With an increasing prevalence, IMN has received considerable attention in China. Based on recent studies, we discuss advances in the diagnosis of IMN and the understanding of its genetic background. Although the pathogenesis of IMN remains unclear, our understanding has been substantially enhanced by the discovery of new antigens such as phospholipase A 2 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
14
0

Year Published

2022
2022
2025
2025

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 23 publications
(14 citation statements)
references
References 73 publications
0
14
0
Order By: Relevance
“…However, responses are wide, and further research is needed to identify those patients who are benefitted by rituximab treatment and those who are non-effective. A clinical study showed that adrenocorticotropic hormone exerted its role through activated melanocortin receptors (MC1R–MC5R) that existed in the whole body were effective therapy for IMN patients who failed immunosuppressive treatment ( Markell et al, 2019 ; Wu et al, 2021b ). Melanocortin one receptor occurred in B cells, T cells, podocytes, and antigen-presenting cells.…”
Section: Treatment Of Membranous Nephropathymentioning
confidence: 99%
“…However, responses are wide, and further research is needed to identify those patients who are benefitted by rituximab treatment and those who are non-effective. A clinical study showed that adrenocorticotropic hormone exerted its role through activated melanocortin receptors (MC1R–MC5R) that existed in the whole body were effective therapy for IMN patients who failed immunosuppressive treatment ( Markell et al, 2019 ; Wu et al, 2021b ). Melanocortin one receptor occurred in B cells, T cells, podocytes, and antigen-presenting cells.…”
Section: Treatment Of Membranous Nephropathymentioning
confidence: 99%
“…The latest study reported that the expression of miR-19b, miR-106a, and miR-17 was significantly downregulated in IMN patients, whereas phosphatase and tensin homolog (PTEN) protein expression was significantly upregulated compared with controls ( Wu et al, 2021 ). The expression of miR-106a and miR-19b was negatively correlated with serum PTEN protein expression, which were positively correlated with serum creatinine, cystatin C, urea, 24 h urine total protein and negatively correlated with albumin and eGFR ( Wu et al, 2021 ). In addition, downregulated miR-500a-5p was identified in kidney tissues of IMN patients, which participated in the regulation of podocyte apoptosis through Circ_0000524/miR-500a-5p/CXCL16 pathway in MN ( Sun et al, 2021 ).…”
Section: Systems Biology-based Mechanisms In Imnmentioning
confidence: 99%
“…It was found that most exostosin-positive patients are complicated by systemic lupus erythematosus or other autoimmune diseases, so NELL-1 might be a target antigen of secondary membranous nephropathy ( Ronco et al, 2006 ), but the mechanisms underlying podocyte injury are not clear. NCAM-1 expression was found in the renal tissues of patients with membranous lupus nephritis and a few primary membranous nephropathies (PMNs), and the antibody was mainly immunoglobulin G1 ( Caza et al, 2021 ; Wu et al, 2021 ). NCAM-1-related MN mainly manifests as GBM thickening and mesangial proliferation ( Sethi, 2021 ).…”
Section: Factors Of Podocyte Injurymentioning
confidence: 99%