A Review of the Evidence for Overlap among Unexplained Clinical Conditions

Aaron, Leslie A.

doi:10.7326/0003-4819-134-9_part_2-200105011-00011

Cited by 429 publications

(295 citation statements)

References 62 publications

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“…Previous studies with probiotics in population with a great comorbidity with FMS, like CFS and IBS (6,11,12,65), have reported beneficial effects after treatment in quality of life (60), pain severity (67), reduced inflammation (68), and emotional symptoms like anxiety (69).…”

Section: Discussionmentioning

confidence: 99%

Probiotics for Fibromyalgia: Study design for a pilot double-blind, randomized controlled trial.

Román

Estévez²,

Sánchez‐Labraca

et al. 2017

Nutr Hosp

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ResumenAntecedentes: el síndrome de fibromialgia (FMS) es un trastorno crónico, generalizado y difuso que produce dolor acompañado de otros síntomas emocionales y cognitivos. Así mismo, los pacientes con FMS muestran una alta comorbilidad de síntomas gastrointestinales. En este sentido, recientemente se ha encontrado que la microbiota intestinal es capaz de regular procesos cerebrales a través del eje intestino-microbiota-cerebro, modulando así a nivel afectivo, emocional, motivacional y de funciones cognitivas complejas. Por lo tanto, el uso de probióticos podría ser una nueva estrategia terapéutica para mejorar el estado físico, psicológico y cognitivo en pacientes con FMS. Sin embargo, aún no hay evidencia disponible sobre este tema. Métodos: este artículo describe el diseño y el protocolo de un estudio piloto doble ciego, controlado con placebo y aleatorizado. Se utilizan cuestionarios validados, tareas cognitivas a través de E-Prime y medidas biológicas como cortisol de orina y muestras de heces. El objetivo del estudio es explorar el efecto de un tratamiento multiespecies probióticas durante ocho semanas en la sintomatología física (dolor, impacto del FMS y calidad de vida), emocional (depresión y ansiedad) y cognitiva (atención, memoria e impulsividad) en pacientes con FMS. Conclusión: el protocolo de este estudio piloto, a nuestro conocer, es el primero que pretende evaluar los efectos de los probióticos en FMS. La hipótesis de partida es que los pacientes con FMS mostrarán un mejor desempeño en las tareas cognitivas y una mejoría en los síntomas emocionales y físicos. Estos resultados contribuirán a una mejor comprensión del eje intestino-cerebral. AbstractBackground: Fibromyalgia syndrome (FMS) is a chronic, generalized and diffuse pain disorder accompanied by other symptoms such as emotional and cognitive deficits. The FMS patients show a high prevalence of gastrointestinal symptoms. Recently it has been found that microbes in the gut may regulate brain processes through the gut-microbiota-brain axis, modulating thus affection, motivation and higher cognitive functions. Therefore, the use of probiotics might be a new treatment that could improve the physical, psychological and cognitive state in FMS; however, no evidence about this issue is available. Methods: This paper describes the design and protocol of a double-blind, placebo-controlled and randomized pilot study. We use validated questionnaires, cognitive task through E-Prime and biological measures like urine cortisol and stool fecal samples. The trial aim is to explore the effects of eight weeks of probiotics therapy in physical (pain, impact of the FMS and quality of life), emotional (depression, and anxiety) and cognitive symptoms (attention, memory, and impulsivity) in FMS patients as compared to placebo. Conclusion: This pilot study is the first, to our knowledge, to evaluate the effects of probiotics in FMS. The primary hypothesis was that FMS patients will show a better performance on cognitive tasks, and an improvement in emotional and ...

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Section: Discussionmentioning

confidence: 99%

Probiotics for Fibromyalgia: Study design for a pilot double-blind, randomized controlled trial.

Román

Estévez²,

Sánchez‐Labraca

et al. 2017

Nutr Hosp

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“…Bununla birlikte bu hastalıkları birbirine bağlayan fizyoloji bilgisi yetersiz kalmaktadır. [80] Fonksiyonel somatik belirti ve sendromlar büyük sağlık sorunlarıdır, bunlar yaygındırlar, kalıcı, günlük hayatı engelleyici ve masraflı olabilirler. Mevcut yayınlar, kronik yorgunluk sendromu, fibromyalji, irritabl barsak sendromu, kronik pelvik ağrı, fonksiyonel dispepsi, atipik göğüs ağrısı, gerilim tipi baş ağrısı, hiperventilasyon sendromu ve temporomandibuler bozukluk gibi pek çok açıklanamayan klinik durumun demografik, klinik ve psikososyal özellik-leri kadar nesnel belirtilerinin de ortak olduğunu göstermektedir.…”

Section: Anksiyete Ve Depresyonun Etkisiunclassified

Psychiatric Aspects of Medically Unexplained Symptoms

Kandemir¹,

Ak²

2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETBedensel belirtileri için tıbbi açıklama bulunamayan hastalar genel tıp uygulamasında oldukça yaygındırlar. Bu hastalar, tüm sağlık hizmeti basmaklarını sıkça kullanırlar. Bu durum kendilerine sağlık hizmeti sunan hekimlerinde hayal kırıklığı yarattığı gibi hastalar da aldıkları tıbbi bakımdan pek memnun olmazlar. Tüm dünyada ve farklı kültürel gruplar arasında bedensel belirtiler toplumsal sorunların ve duygusal sıkıntının en yaygın bireysel ifadeleridir. Tıbben açıklanamayan belirtilere hasta grubunda depresyon ve anksiyete başta olmak üzere diğer psikiyatrik durumlar eşlik etmektedir. Bu gözden geçirme yazısında tıbben açıklanamayan belirtilere ve psikiyatrik belirtiler arasındaki ilişki incelenmesi amaçlanmıştır. Anahtar Sözcükler: Tıbben açıklanamayan belirti, anksiyete,depresyon. ABSTRACTThe patients with medically unexplained symptoms for their physical symptoms are generally prevalent in the primary care consultation. Such patient, frequently consume primary and secondary healthcare services and it is a situation that disappointed medical stuff and also patients are uncomfortable for medical services. Physical symptoms commonly are regarded as products of emotional and social problems between different cultural groups and over the world. Generally, depression and anxiety and other psychiatric conditions accompany to patient group with medically unexplained symptoms. The aim of this review article is to investigate the relationship between medically unexplained symptoms and psychiatric symptoms.

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“…A common theme with these 'unexplained symptom complexes' is that the disability seems to be out of proportion to physical findings [1,2]. The place of these symptom based disorders within the nosology of clinical medicine is uncertain.…”

Section: Introductionmentioning

confidence: 99%

Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome

Santelmann

Howard²

2005

European Journal of Gastroenterology & Hepatology

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Many patients with irritable bowel syndrome (IBS) are disillusioned by the lack of efficacy of treatments and suffer from numerous symptoms not covered by the Rome criteria for IBS, as the current empirical treatment regimes fail to address these persistent debilitating 'IBS associated symptoms'. These symptoms are similar to other symptom complexes like chronic fatigue and the so called 'candida syndrome', and many seek help from alternative medicine. The possible role of Candida and yeasts in non-immune compromised individuals is disputed and is the subject of this review. Even if the involvement of yeasts in the aetiology of IBS still remains unclear, there is increasing evidence for yeasts being able to cause IBS-symptoms in sensitized patients via Candida products, antigens and cross-antigens. But more research is needed before antifungal treatment can be recommended as a first line treatment for IBS.

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A Review of the Evidence for Overlap among Unexplained Clinical Conditions

Abstract: Overlap between unexplained clinical conditions is substantial. Most studies are limited by methodologic problems, such as case definition and the selection and recruitment of case-patients and controls.

Cited by 429 publications

References 62 publications

Probiotics for Fibromyalgia: Study design for a pilot double-blind, randomized controlled trial.

Probiotics for Fibromyalgia: Study design for a pilot double-blind, randomized controlled trial.

Psychiatric Aspects of Medically Unexplained Symptoms

Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome

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