A review of the impact of oxidative stress and some antioxidant therapies on renal damage

Tamay‐Cach, Feliciano; Quintana-Pérez, Julio César; Trujillo‐Ferrara, José G.; Cuevas‐Hernández, Roberto I.; Valle-Mondragón, Leonardo Del; García-Trejo, Ehécatl M. A.; Arellano-Mendoza, Mónica Griselda

doi:10.3109/0886022x.2015.1120097

Cited by 22 publications

(12 citation statements)

References 43 publications

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“…Also, some studies have reported the association of low-level Cd exposure with decreased eGFR, supporting the hypothesis that trace exposure to Cd may contribute to the development of CKD ( Åkesson et al , 2014 ; Ferraro et al , 2010 ). There are also studies suggesting that oxidative stress is also involved in the onset of CKD ( Tamay-Cach et al , 2015 ).…”

Section: Discussionmentioning

confidence: 99%

MetallothioneinMT2AA-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies

et al. 2016

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Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney disease (CKD), and diabetes mellitus (DM), in a community-dwelling population. Study subjects were Nagoya city residents participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC) Daiko Study, comprised 749 men and 2,025 women, aged 39–75 years. CKD (>stage 3) and DM were defined by standard guidelines. Associations were evaluated using logistic regression models with adjustments for age, sex and potential confounders in a cross-sectional study, and verified in a 5-year longitudinal study. Odds ratios (OR [95% confidence interval]) were calculated relative to the AA genotype. Serum MT (I + II), Cd and zinc levels were also determined by genotype. The OR of the GG genotype for CKD risk was 3.98 (1.50, 10.58) in the cross-sectional study and 5.17 (1.39, 19.28) in the longitudinal study. The OR of the GA genotype for DM was 1.86 (1.26, 2.75) in the cross-sectional study and 2.03 (1.19, 3.46) in the longitudinal study. MT2A A-5G may be associated with CKD and DM risks. This polymorphism is a promising target for evaluations of CKD and DM risks with possible involvement of low-dose chronic exposure to environmental pollutants.

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Section: Discussionmentioning

confidence: 99%

MetallothioneinMT2AA-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies

et al. 2016

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“…Dietary intake of antioxidants has been associated with reduced risks of some of the aforementioned diseases [6,7]. The effectiveness of antioxidant therapies in preventing and/or managing human pathologies was also highlighted [8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

et al. 2017

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Marine invertebrates, such as oysters, mussels, clams, scallop, jellyfishes, squids, prawns, sea cucumbers and sea squirts, are consumed as foods. These edible marine invertebrates are sources of potent bioactive peptides. The last two decades have seen a surge of interest in the discovery of antioxidant peptides from edible marine invertebrates. Enzymatic hydrolysis is an efficient strategy commonly used for releasing antioxidant peptides from food proteins. A growing number of antioxidant peptide sequences have been identified from the enzymatic hydrolysates of edible marine invertebrates. Antioxidant peptides have potential applications in food, pharmaceuticals and cosmetics. In this review, we first give a brief overview of the current state of progress of antioxidant peptide research, with special attention to marine antioxidant peptides. We then focus on 22 investigations which identified 32 antioxidant peptides from enzymatic hydrolysates of edible marine invertebrates. Strategies adopted by various research groups in the purification and identification of the antioxidant peptides will be summarized. Structural characteristic of the peptide sequences in relation to their antioxidant activities will be reviewed. Potential applications of the peptide sequences and future research prospects will also be discussed.

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“…Other studies have also compared the patients' cognitive status with a control group using the MMSE; in this study, however, since the aim was to determine the effect of CoQ10 supplement on dialysis patients' cognitive status, the MMSE scores of the supplement group were not compared with a non-dialysis control group, rather, the changes in the cognitive status of hemodialysis patients under the effect of CoQ10 supplement were compared with a hemodialysis group that did not receive this supplement. Previous studies have also addressed the effect of CoQ10 supplementation in preventing the progress of renal disease and have reported positive effects for this supplement (39)(40)(41)(42).…”

Section: Discussionmentioning

confidence: 99%

The effect of coenzyme Q10 on cognitive status in chronic hemodialysis patients; a double-blind, randomized, clinical trial

2018

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Introduction: Renal failure is a stressful process that has several complications, including neurological disorders such as cognitive disorder, which can lead to the incidence of psychological disorders. Objectives: Given the reduced coenzyme Q10 levels in patients with chronic renal failure and the known role of this coenzyme in cognitive disorders, the present study was conducted to assess the effect of CoQ10 supplementation in the treatment of cognitive disorder in hemodialysis patients in Semnan, Iran. Patients and Methods: The present double-blind, randomized, clinical trial was conducted on patients with chronic renal failure undergoing hemodialysis at Kosar Hospital of Semnan. The participants underwent a cognitive assessment using the Mini-Mental State Examination (MMSE). They were then randomly divided into two groups; group one received CoQ10 supplement and group two received placebo for 90 days, after which period they underwent another cognitive assessment using the MMSE. The Kolmogorov-Smirnov test and Levene’s test were used to verify the normal distribution of the data. Data were analyzed using the t test and Mann–Whitney U test at a significance level of P<0.05. Results: There were no statistically significant differences between the two groups in terms of their personal details. The mean (± standard deviation) of the MMSE1 score was 21.29±6.5 in the control group and 21.09±5.4 in the case group. The mean (± standard deviation) of the MMSE2 score was 20.62±6.5 in the control group and 23.29±5.8 in the case group. A significant difference between the two groups in terms of their pre- and post-intervention MMSE scores was observed, suggesting the positive effect of the medication (P<0.001). Conclusion: The daily intake of CoQ10 100-mg led to a significant change in the cognitive status of chronic hemodialysis patients compared to the group that received only the placebo. Conducting a similar study but with the addition of a healthy control group is recommended in order to establish a base measure for the healthy population and to thus enable the better interpretation of the effect of this supplement.

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A review of the impact of oxidative stress and some antioxidant therapies on renal damage

Cited by 22 publications

References 43 publications

MetallothioneinMT2AA-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies

MetallothioneinMT2AA-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

The effect of coenzyme Q10 on cognitive status in chronic hemodialysis patients; a double-blind, randomized, clinical trial

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