A review of the mechanisms of anti-cancer activities of some medicinal plants–biochemical perspectives

Patrick, E.; Ihedioha, John Ikechukwu; Asuzu, Isaac Uzoma

doi:10.1515/jbcpp-2021-0257

Cited by 10 publications

(8 citation statements)

References 92 publications

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“…Polyphenolic compounds also possess various other biological activities, such as reducing plasma lipids, which might be due to up-regulation of LDL receptor expression 30 and inhibition of hepatic lipid synthesis. Saponins, polyphenolic compounds, and gallic tannins possess potent inhibition of intestinal glucose transport by inhibiting sodium-glucose cotransporter-I (S-GLUT-1) intestines 31 . Diabetic M. oleifera treated rabbits increased in body weight.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2022

IJPSR

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The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclamide (5 mg/kg/day). To determine fasting blood glucose, blood was drawn on days 1, 7, and 14, while it was drawn on day 14 for the determination of lipids, and relative body weight was measured at days 0 and 14. After 2 weeks of treatment, the fasting blood glucose levels of the MO-fed groups were significantly lower when compared with the diabetes mellitus (DM) group (P < 0.05), and the results were compared with standard Glibenclamide drug. Treatment with the MO also resulted in a significant decrease in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P< 0.05) accompanied by a significant increase in serum high-density lipoprotein cholesterol (P< 0.05). The overall results suggest that the MO possesses potential hypoglycemic and hypolipidemic activity in alloxan-induced diabetic rabbits. INTRODUCTION:Moringa oleifera (Moringaceae) is a fast-growing perennial species native to North-western India, now cultivated in many parts of the world. This species has been used in folk medicine for the treatment of diabetes 1-3 . Scientists have shown Moringa cures type 1 diabetes and type 2. Type 1 diabetes is when patients do not produce insulin, which maintains a level of blood glucose at the necessary standard value.

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Section: Resultsmentioning

confidence: 99%

Untitled

2022

IJPSR

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“…For their possible antidiabetic properties, different alkaloids have been taken from a range of herbal plants and tested on diverse animal species. 52 It has been suggested that it is one of the active ingredients in some plants used to treat diabetes. 53 In order to reduce diabetic retinopathy, certain alkaloids include: betaine, cannabidiol, and sinomenine.…”

Section: Phytochemicals For Diabetic Retinopathy Managementmentioning

confidence: 99%

Pathological pathway and protective mechanisms of phytobioactives used in diabetic retinopathy: A review

Badruddeen

Zia

Akhtar

et al. 2023

Preprint

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Diabetes mellitus (DM) is caused by either inadequate or dysfunctional insulin. It is one leading causes of Diabetic retinopathy (DR). Many synthetic medications have serious adverse effects that exacerbate the diabetic patient’s condition. The discovery of phytochemicals from medicinal plants offers a promising possibility for the creation of novel therapies for diabetes and its complications including DR. This review highlighted pathological mechanism of DR and also describe numerous plant-derived small compounds (phytochemicals) that have been studied in pre-clinical and clinical settings for their potential to have retinal cytoprotective effects. This also emphasise the mechanism retinal cryoprotection of phytochemicals. The sources were retrieved from various database such as Science Direct, Google Scholar, PubMed, Medline etc. In various studies, phytochemicals reduced inflammation, apoptosis pathways and oxidative stress, which inhibited the development of DR. Numerous phytochemicals, including flavonoids, lignan, glycosides, phytoestrogen etc., inhibited the production of Reactive Oxygen Species (ROS) and downregulation the inflammatory markers such as Interleukin-6(IL-6), Interleukin-1β(IL-1β), and Tumor necrosis factor-α (TNF-α). Overall most of the phytochemicals shows retinal cryoprotection by reducing generation of free radicals and inflammatory mediators.

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“…Phytochemicals exhibits hope of new routes and techniques with a view to successful implementation of diabetes disease management. Phytochemicals are a group of entities with such to say different classes [36][37][38][39]. Knowing and starting a path with their mechanism of action and using them as an adjunctive therapy is relevant in evidence-based training and improvement of personalized lines to avoid complications for diabetics [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

“…They prevent DNA damage and genome mutation and modulate the intracellular pathways leading to cell survival and apoptosis. As regards their effectiveness, flavonoids like quercetin, kaempferol and luteolin have behaved well in preventing β-cells damage caused by dysfunction and apoptosis [36]. The bioactive component seen in turmeric, another name for curcumin, is the one that belongs to the realm of traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Exploring Phytochemicals for Diabetes Management: Mechanisms, Efficacy, and Future Directions

Onukwuli,

zuchukwu,

Ugwu

2024

NIJRMS

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In the realm of global health diplomacy, diabetes mellitus undoubtedly poses a significant challenge. Furthermore, there is a pressing need to explore alternative and complementary therapies. Phytochemicals, which are naturally occurring bioactive compounds found in plants, exhibit distinct biochemical properties, rendering them promising candidates for diabetes management. This review focuses on the potential of various classes of phytochemicals, including polyphenols, alkaloids, terpenoids, organosulfur compounds, and polysaccharides, in diabetes management. Each class demonstrates unique mechanisms of action, contributing to therapeutic effects such as enhancing insulin sensitivity, reducing carbohydrate digestion and glucose absorption, regulating antioxidant stress, inflammation, and glucose metabolism. While successful preclinical trials provide valuable insights, further rigorous clinical trials are imperative to ascertain the therapeutic efficacy, optimal dosage, bioavailability, and potential interactions with concomitant medications. Understanding the functional pathways of plant-derived substances is crucial, as it enables the formulation of precise strategies for incorporating them as dietary supplements for individuals with diabetes mellitus. Keywords: Phytochemicals, diabetes mellitus, insulin sensitivity, glucose metabolism, oxidative stress, and inflammation.

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A review of the mechanisms of anti-cancer activities of some medicinal plants–biochemical perspectives

Cited by 10 publications

References 92 publications

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Pathological pathway and protective mechanisms of phytobioactives used in diabetic retinopathy: A review

Exploring Phytochemicals for Diabetes Management: Mechanisms, Efficacy, and Future Directions

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