A review of the off-label use of selamectin (Stronghold®/Revolution®) in dogs and cats

Fisher, Maggie; Shanks, D.J

doi:10.1186/1751-0147-50-46

Cited by 33 publications

(14 citation statements)

References 15 publications

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“…abstrusus and C . aerophila in clinical trials, given the scant reports published thus far [188-190]. The recent reports of the efficacy of the spot-on formulation containing moxidectin in the treatment of feline aelurostrongylosis and capillariosis [169,191] should encourage further studies aiming to also investigate the applicability of chemopreventative approaches against these parasites, as recently assessed for dog angiostrongylosis [136].…”

Section: Resultsmentioning

confidence: 99%

Fleas infesting pets in the era of emerging extra-intestinal nematodes

Traversa

2013

Parasites Vectors

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Modifications in climatic conditions, movements of hosts and goods, changes in animal phenology and human behaviour and increase of wildlife, are presently concurring in the geographic spread of vectors and cardio-respiratory nematodes, e.g. Dirofilaria immitis, Angiostrongylus vasorum, Aelurostrongylus abstrusus and Capillaria aerophila. All these factors may also influence dispersion and clinical significance of fleas, thus posing relevant challenges in those regions where other parasites are emerging at the same time. Ctenocephalides felis, Ctenocephalides canis and Pulex irritans cause discomfort, nuisance, allergic reactions, anaemia, and may transmit several pathogens, some of them are of importance for public health. The present article reviews the importance of fleas in small animal practice and their sanitary relevance for dogs, cats and humans, and discusses current control methods in the present era of emerging extra-intestinal nematodes, towards a possible changing perspective for controlling key parasites affecting companion animals.

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Section: Resultsmentioning

confidence: 99%

Fleas infesting pets in the era of emerging extra-intestinal nematodes

Traversa

2013

Parasites Vectors

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“…In the few reports investigating activity against harvest mites, none had a control group [12,13,22]. We elected to include a control group to ensure that the reduction of the lesions in dogs receiving the treatment was not spontaneous and avoid misinterpretation of the results as trombiculiosis is a seasonal skin disorder.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Harvest Mite Infestation in Dogs Using a Permethrin 54.5% and Fipronil 6.1% (Effitix®) Topical Spot-On Formulation

Lecru

Combarros

Castilla-Castaño

et al. 2019

Veterinary Sciences

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Background—The study aims to assess the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution in dogs naturally infested with Neotrombicula in an open-label controlled study. Methods—Ten naturally infested dogs received one drop per affected site on day (D) 0, and on D14, the rest of the pipette was applied on the skin between the shoulders. Five dogs served as sentinels. Parasite score (0–3), skin lesions (0–4), and investigator pruritus scale (0–4) were assessed on D0, D1, D14, and D28. Results—No treated dogs developed adverse reactions. Parasite score of sentinel dogs was maintained between 1.8 (D0, D1, and D28) and 2.2 (D14). In treated dogs, D0 parasite score was 2.4. It was significantly reduced from D1 (0.5; p < 0.002) to D28 (0.1; p < 0.002). The lesion score was 2.9 on D0 and D1; it was significantly reduced on D14 (0.6; p < 0.002) and D28 (0.1; p < 0.002). Similarly, investigator pruritus scale (D0, 2.2) scores significantly decreased on D14 (0.4; p < 0.004) and D28 (0.2; p < 0.002). Conclusions—The combination permethrin-fipronil appears to be well-tolerated, rapidly and durably effective in the control of localized canine harvest mite infestation.

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“…In clinical trials, it was found to be a highly effective and broad-spectrum drug that was safe for animals (including rhesus macaques, dogs, cats, rats, rabbits, and ferrets; Esatgil et al 2008;Fisher and Shanks 2008;Kim et al 2008;Miller et al 2006;Wang et al 2008a).…”

Section: Discussionmentioning

confidence: 99%

Haemaphysalis concinna (Acari: Ixodida): persistent efficacy of selamectin in Angora rabbits under laboratory conditions

et al. 2011

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In the present study, the persistent efficacy of selamectin (SEL) in Angora rabbits infested with Haemaphysalis concinna was observed. SEL (6 mg/kg) was administered to rabbits with a single topical application. Eighteen Angora rabbits were randomly allocated to three groups of six rabbits each. At days 1, 8, 15, 22, and 29 following SEL administration, rabbits were inoculated with larval, nymphal, and adult ticks and were then observed for a period of 7 days. The cumulative reduction rates at days 1, 8, 15, 22, and 29 for dead ticks were 100%, 100%, 100%, 95.0%, and 76.7%, respectively, for larvae; 100%, 100%, 100%, 85.0%, and 65.0%, respectively, for nymphs; and 100%, 95.0%, 85.0%, 60.0%, and 45.0%, respectively, for adults. The cumulative reduction rates for larvae in untreated Angora rabbits (controls) were 3.3%, 1.7%, 3.3%, 5.0%, and 5.0%, respectively. There was no reduction of nymphs and adults in untreated Angora rabbits (controls). The reduction rates for larvae, nymphs, and adults were significantly higher for Angora rabbits inoculated with SEL than the controls (P < 0.001).

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A review of the off-label use of selamectin (Stronghold®/Revolution®) in dogs and cats

Cited by 33 publications

References 15 publications

Fleas infesting pets in the era of emerging extra-intestinal nematodes

Fleas infesting pets in the era of emerging extra-intestinal nematodes

Treatment of Harvest Mite Infestation in Dogs Using a Permethrin 54.5% and Fipronil 6.1% (Effitix®) Topical Spot-On Formulation

Haemaphysalis concinna (Acari: Ixodida): persistent efficacy of selamectin in Angora rabbits under laboratory conditions

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