A Review of the Pharmacological Characteristics of Vanillic Acid

Abstract

A dihydroxybenzoic acid analog used as a flavoring agent is vanillic acid (4hydroxy-3-methoxybenzoic acid). It's a form of vanillin that has been oxidized. It's also a step in the process of making vanillin from Ferulic Acid. Vanillic acid has seen a lot of press because of its many uses in the cosmetics, fruit, flavorings, cigarettes,alcohols, drinks, and polymer sectors. It's said to have effective antioxidant, anti-inflammatory, and neuroprotective properties. The pharmacological impact on oxidative stress-induced neuro-degeneration, on the other hand, have not been thoroughly examined. The pharmacological properties of vanillic Acid lead to its possible use in the treatment of various diseases.
 Keywords: Vanillic acid, Pharmacological Potential, wound healing, Antioxidants

A Comparative Study of the Influence of Various Fungal-Based Pretreatments of Grape Pomace on Phenolic Compounds Recovery

“…In the untreated sample, the content of syringic acid was 86.37 ± 2.15 µg/g db , and in the sample after 10 days of biological treatment with PE, the content was 205.13 ± 0.01 µg/g db ( Table 2 ). Syringic acid and vanillic acid may affect the reduction of the quantitative marker of fibrosis, liver hydroxyproline, and suppress the aggregation of collagen [ 49 ].…”

“…It is mainly used in the cosmetic industry for its protective function for important skin structures such as elastin, collagen, keratinocytes, and fibroblasts, and is used in skin care formulations as a photoprotectant, to delay photoaging of the skin, and as a brightening component. It also accelerates wound healing, inhibits melanogenesis and promotes angiogenesis [ 49 , 54 ]. The increase of ferulic acid extractability was affected by biological treatment with GL and GR during the first 5 days, and by biological treatment of GP with PC and CS after the first day of fermentation, as shown in Figure 6 a,b.…”

Chemical profiling of Punica granatum peels from Jordan using LC–MS/MS and study on their biological activities

“…A total of 19 phenolic acids and flavonoids were detected in the crude ethanol peel extract of P. granatum including six hydroxybenzoic acids such as syringic acid, vanillic acid, ellagic acid, gallic acid, p‐hydroxybenzoic acid and corilagin; six hydroxycinnamic acids such as chlorogenic acid, caffeic acid, sinapic acid, p‐coumaric acid, ferulic acid and cinnamic acid; and seven flavonoids compounds such as apigenin, quercetin, pelargonidin, cyanidin, catechin, epicatechin and anthocyanins. Phenolics naturally occur in a wide range of species throughout the plant kingdom and are recognised as good medicines, exhibiting a broad spectrum of antioxidant, antibacterial, anti‐inflammatory, antidiabetic, anticancer, antithrombotic anti‐ischaemic and antitumour activities (Khadem & Marles, 2010; Grzesik et al., 2018; Gupta et al., 2019; Salehi et al., 2019; Alfei et al., 2020; Li et al., 2020; Ruwizhi & Aderibigbe, 2020; Salau et al., 2020; Shim et al., 2020; Tena et al., 2020; Vo et al., 2020; Basavegowda & Baek, 2021; Ingole et al., 2021; Jug et al., 2021; Nguyen et al., 2021). They also have a vital role as a natural preservative in most common foods, cosmetics and medicines (de Paulo Farias et al., 2020).…”

1,2-Bis(pyridin-4-yl)ethene–4-hydroxy-3-methoxybenzoic acid (1/1)

“…4-Hydroxy-3-methoxybenzoic acid, C 8 H 8 O 4 , known commonly as p-vanillic acid, is used as a flavoring agent and naturally found in a variety of fruits and edible plants (Ingole et al, 2021). In addition, p-vanillic acid is currently being investigated for its inflammatory pain-inhibiting properties (Calixto-Campos et al, 2015).…”