A review of the relationship between long noncoding RNA and post-stroke injury repair

Wang, Yao; Pan, Weiyi; Ge, Jun-Sheng; Wang, Xiaodong; Chen, Wei; Luo, Xun; Wang, Yulong

doi:10.1177/0300060519867493

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…Many aberrant lncRNA expressions such as MEG3, H19, MALAT1, ZFAS1, GAS5, LincRNA-EPS, SHNG16, etc. were suggested to regulate cell apoptosis, angiogenesis, inflammation and cell death in different brain cell types after stroke [ 116 , 117 , 118 , 119 , 120 , 121 , 122 ]. NSCs express lncRNAs and the functions of lncRNAs in the self-renewal and differentiation of stem cells are beginning to be appreciated [ 123 , 124 , 125 ].…”

Section: Epigenetics In Adult Neurogenesis After Strokementioning

confidence: 99%

Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis

Liu

Fan

Chopp

et al. 2020

IJMS

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Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to augment neurogenesis. Epigenetic mechanisms include DNA methylation, histone modification and its mediation by microRNAs and long-non-coding RNAs. In this review, we highlight how epigenetic factors including DNA methylation, histone modification, microRNAs and long-non-coding RNAs mediate stroke-induced neurogenesis including neural stem cell self-renewal and cell fate determination. We also summarize therapies targeting these mechanisms in the treatment of stroke.

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Section: Epigenetics In Adult Neurogenesis After Strokementioning

confidence: 99%

Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis

Liu

Fan

Chopp

et al. 2020

IJMS

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“…lncRNAs are highly specific in the central nervous system and stroke is known to induce changes in several lncRNAs in the brain. Therefore, lncRNAs play a crucial role in the complex pathological processes associated with stroke, and may regulate the development of the central nervous system and disease progression ( 10 ). During the tra/rensplantation of lungs, kidneys and other organs, ischemia/reperfusion (I/R) is a critical factor affecting the success rate of organ transplantation ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

An update on the functional roles of long non‑coding RNAs in ischemic injury (Review)

Cao

Liu

et al. 2022

Int J Mol Med

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Ischemic injuries result from ischemia and hypoxia in cells. Tissues and organs receive an insufficient supply of nutrients and accumulate metabolic waste, which leads to the development of inflammation, fibrosis and a series of other issues. Ischemic injuries in the brain, heart, kidneys, lungs and other organs can cause severe adverse effects. Acute renal ischemia induces acute renal failure, heart ischemia induces myocardial infarction and cerebral ischemia induces cerebrovascular accidents, leading to loss of movement, consciousness and possibly, life-threatening disabilities. Existing evidence suggests that long non-coding RNAs (lncRNAs) are regulatory sequences involved in transcription, post-transcription, epigenetic regulation and multiple physiological processes. lncRNAs have been shown to be differentially expressed following ischemic injury, with the severity of the ischemic injury being affected by the upregulation or downregulation of certain types of lncRNA. The present review article provides an extensive summary of the functional roles of lncRNAs in ischemic injury, with a focus on the brain, heart, kidneys and lungs. The present review mainly summarizes the functional roles of lncRNA MALAT1, lncRNA MEG3, lncRNA H19, lncRNA TUG1, lncRNA NEAT1, lncRNA AK139328 and lncRNA CAREL, among which lncRNA MALAT1, in particular, plays a crucial role in ischemic injury and is currently a hot research topic.

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“…Around 99% of mammalian genomes are pervasively transcribed into noncoding RNAs (ncRNAs), and most of which are lncRNAs [6]. LncRNAs can regulate target gene expression by affecting histone modification, chromatin remodeling and protein functional activity [7].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of lncRNA expression profiles in rats with cerebral ischemia-reperfusion injury after treatment with 20(R)-ginsenoside Rg3

Yang¹,

He²,

Yang³

et al. 2022

J. Integr. Neurosci.

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This study was aimed at investigating the di ferentially expressions of long noncoding RNAs (lncRNAs) and mRNAs in the brains of a middle cerebral artery occlusion/reperfusion (MCAO/R) group and a MCAO/R + 20(R)-Rg3 group. Biological enrichment analysis was performed, and a lncRNA-mRNA coexpression network was constructed, to reveal the targets and pathways of 20(R)-Rg3 involved in the regulation of cerebral ischemia-reperfusion injury (CIRI). The RNA-seq high-throughput sequencing method was employed to detect di ferentially-expressed genes between the groups, which were verified by RT-PCR. Functional enrichment analyses of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were performed to explore the biological functions and relevant pathways. The coexpression network of the screened lncRNAs and mRNAs was built by using Cytoscape so tware. The results identified 77 upregulated lncRNAs, 162 downregulated lncRNAs, 66 upregulated mRNAs and 472 downregulated mRNAs in the MCAO/R + 20(R)-Rg3 group, compared with those in the MCAO/R group. GO enrichment analysis showed that the GO terms were mainly enriched in stimulation response, cellular response, and stress response. KEGG pathways were mainly related to the tumor necrosis factor (TNF), NF-κB, cytokine, and other receptor signaling pathways. In addition, the coexpression analysis between lncRNA and mRNA identified 314 nodes and 515 connections between 6 lncR-NAs and 308 mRNAs, of which 511 were positive and 4 were negative. Among them, ENSRNOG-00000059555 was strongly correlated with AABR07001160.1. This study revealed multiple lncRNAs were involved in the neuroprotection of 20(R)-Rg3 against CIRI and thereby provided new insights into the use of 20(R)-Rg3 as a novel neuro protectant in ischemic stroke management.

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A review of the relationship between long noncoding RNA and post-stroke injury repair

Cited by 9 publications

References 34 publications

Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis

Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis

An update on the functional roles of long non‑coding RNAs in ischemic injury (Review)

Comprehensive analysis of lncRNA expression profiles in rats with cerebral ischemia-reperfusion injury after treatment with 20(R)-ginsenoside Rg3

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