A review of the risk factors associated with juvenile-onset recurrent respiratory papillomatosis: genetic, immune and clinical aspects

Li, Shilan; Wang, Wei; Zhao, Jing; Zhang, Jie; Ni, Xin

doi:10.1007/s12519-021-00496-z

Cited by 12 publications

(3 citation statements)

References 70 publications

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“…The part II of the study showed that the interval between operations was affected by the age of onset, Derkay score, and surgical method. There are studies found clinical features such as younger age and HPV-11 infection in patients are more dangerous [28] .In our study, or JO-RRP, the interval between operations is related to the age of onset, Derkay score, and surgical modality, but not gender. The interval between surgeries increases with age, and the higher the Derkay score, the shorter the spacing between surgeries.…”

Section: Discussionmentioning

confidence: 44%

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Liu,

He,

et al. 2023

Preprint

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Objectives: Part I analyzes the clinical characteristics of JO-RRP and AO-RRP. Part II explores the influencing factors of surgical intervals. Methods: Part I: Clinical features were analyzed in 168 RRP patients (59 JO-RRP and 109 AO-RRP) diagnosed and treated in our hospital. Part II: The correlation of interoperative time with onset age, gender, Derkay anatomical score or surgical methods were analyzed in JO-RRP patients. Results: The interoperative time between operations in the JO-RRP group was 116.3±75.9 days, and in the AO-RRP group was 169.1±141.7 days (p<0.05). In the JO-RRP group, the CO2 laser treatment interval (186.2±140.1 days) was significantly longer than that of the microdebrider group (124.7±114.5 days) (p=0.011). Conclusions: 1. JO-RRP patients had higher Derkay score, higher surgical frequency and shorter surgical interval. 2. The surgical intervals lengthened with age and shortened with higher Derkay scores. CO2 laser surgery has the longest interoperative time.

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Section: Discussionmentioning

confidence: 44%

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Liu,

He,

et al. 2023

Preprint

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“…The disease is typically diagnosed at the age of 2-3 years and there is a strong etiological association with human papilloma virus (HPV) infection, especially HPV 6 and HPV 11 subtypes, with higher prevalence of HPV6 [8]. HPV infection in affected newborns probably occurs when the fetus passes through an infected birth canal; however other ways of transmission have been proposed, such as vertical transmission in utero and horizontal transmission via the child's environment [9,10]. JORRP has a strong negative impact on patients' quality of life, with more than four average surgeries performed in the first year following diagnosis [11].…”

Section: Juvenile-onset Recurrent Respiratory Papillomatosismentioning

confidence: 99%

Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors

Soloperto

Gazzini

Cerullo

2023

IJMS

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Primary tumors of the airways in the pediatric population are very rare entities. For this reason, little is known about the pathogenesis of these neoplasms. Understanding the biology has different practical implications: for example, it could help in the differential diagnosis, have a prognostic significance, or may lead to the development of a targeted therapy. The aim of this article is to present the current knowledge about pediatric airways tumors, focusing on the molecular mechanisms that cause the onset and progression of these neoplasms. After a brief introduction of epidemiology and clinical presentation, the tumorigenesis of the most frequent pediatric airways tumors will be described: Juvenile-onset recurrent respiratory papillomatosis (JORRP), Subglottic Hemangiona (SH), Rhabdomyosarcoma (RMS), and Mucoepidermoid carcinoma (MEC).

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“…Genetically, the presence of DRB1*0301 and HPV 6/11 E6/E7 is associated with more severe disease [ 15 ]. However, compared with HPV type, age at first onset is a more important factor related to the aggressiveness of juvenile RRP [ 15 ]. The risk for malignant transformation is less than 1% [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Early Identification and Intervention in Malignant Transformation of Respiratory Papillomatosis

et al. 2022

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Unusual clinical course Background:Human papilloma virus is a ubiquitous and preventable disease with the potential to cause recurrent respiratory papillomatosis. These papillomas affect the mucosal surface of the airways and may lead to airway obstruction. The papillomas require excision when breathing is compromised, and may be fatal if untreated. Rarely, these papillomas progress to cancer. Case Report:We report the case of a 21-year-old woman with a history of HPV 11-and 16-positive recurrent laryngeal and respiratory papillomatosis (RRP) since the age of 7 months, requiring multiple local resections in her respiratory tract. Chest CT demonstrated multiple cavitary lesions throughout both lungs with a rapidly growing mass that occupied most of her right lung. Imaging supported a diagnosis of malignant transformation to squamous cell carcinoma of the lung. Bilateral involvement of the lungs indicated stage IVa squamous cell lung cancer, which is not curable. Conclusions:Clinicians should suspect malignant transformation in patients with HPV type 11, especially if they have required multiple excisions. Earlier age at onset and number of excisions may be predictors for severity of the disease course. These patients need continued surveillance imaging to allow early interventions if malignant transformation occurs. We present the case of a 21-year-old being diagnosed with an incurable disease that may have been avoided with adequate preventive care.

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A review of the risk factors associated with juvenile-onset recurrent respiratory papillomatosis: genetic, immune and clinical aspects

Cited by 12 publications

References 70 publications

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors

Early Identification and Intervention in Malignant Transformation of Respiratory Papillomatosis

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