A review of the role of carbon nanotubes for cancer treatment based on photothermal and photodynamic therapy techniques

Naief, Mohammed Faiad; Mohammed, Samar Naser; Mayouf, Hadil Jubair; Mohammed, Ahmed Mishaal

doi:10.1016/j.jorganchem.2023.122819

Cited by 34 publications

(4 citation statements)

References 85 publications

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“…Photothermal agents can consist of organic and inorganic compounds. The most commonly used inorganic compounds are noble metals such as gold (Au) [ 134 ], silver (Ag) [ 135 ], palladium (Pd) [ 136 ], and platinum (Pt) [ 137 ]; carbon-based compounds can also be used, such as graphene [ 138 ], graphene oxide, and carbon dots [ 139 ]. Organic compound-based photothermal therapy uses polymer nanoparticles [ 140 ] and organic dyes [ 141 ], among other materials [ 142 ].…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Barba-Rosado,

Carrascal-Hernández,

Insuasty

et al. 2024

Nanomaterials

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Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer is bone cancer, such as osteosarcoma and Ewing tumors, which occur more frequently in infants. This study shows an active interest in the use of graphene oxide and its derivatives in therapy against bone cancer. We present a systematic review analyzing the current state of the art related to the use of GO in treating osteosarcoma, through evaluating the existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications against osteosarcoma were reviewed, which has revealed that there is an excellent trend toward the use of GO-based nanomaterials, based on their thermal and anti-cancer activities, for the treatment of osteosarcoma through various therapeutic approaches. However, more research is needed to develop highly efficient localized therapies. It is suggested, therefore, that photodynamic therapy, photothermal therapy, and the use of nanocarriers should be considered as non-invasive, more specific, and efficient alternatives in the treatment of osteosarcoma. These options present promising approaches to enhance the effectiveness of therapy while also seeking to reduce side effects and minimize the damage to surrounding healthy tissues. The bibliometric analysis of photothermal and photochemical treatments of graphene oxide and reduced graphene oxide from January 2004 to December 2022 extracted 948 documents with its search strategy, mainly related to research papers, review papers, and conference papers, demonstrating a high-impact field supported by the need for more selective and efficient bone cancer therapies. The central countries leading the research are the United States, Iran, Italy, Germany, China, South Korea, and Australia, with strong collaborations worldwide. At the same time, the most-cited papers were published in journals with impact factors of more than 6.0 (2021), with more than 290 citations. Additionally, the journals that published the most on the topic are high impact factor journals, according to the analysis performed, demonstrating the high impact of the research field.

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Section: Resultsmentioning

confidence: 99%

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Barba-Rosado,

Carrascal-Hernández,

Insuasty

et al. 2024

Nanomaterials

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“…By using the laser to activate the photosensitizer (PS), PDT can generate lots of cytotoxic reactive oxygen species (ROS) to accurately kill tumors. 1 Actually, there exist two types of mechanisms for the generation of ROS during PDT. In the I-type process, the activated PS can transfer its energy to the intracellular substrates ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Lu,

Xue,

Dong

et al. 2024

J. Mater. Chem. B

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“…The challenges mentioned can be effectively addressed through the development of innovative functional nanomaterials, enabling the exploration of new therapeutic approaches for combatting cancer. Notable examples include lipid nanoparticles and dendrimers, which offer a precise way to deliver therapeutic agents to cancer cells in target tissues [2], and magnetic and silica nanoparticles proposed for early detection and the application of magnetic hyperthermia therapy [3], while carbon nanotubes have shown potential in photothermal therapies [4]. On the other hand, gold and silver nanoparticles have been used for targeted drug delivery to enhance the efficacy of chemotherapy and phototherapy [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Novel Gold Nanorods@Thiolated Pectin on the Killing of HeLa Cells by Photothermal Ablation

Beltran,

Luna,

Gastelum

et al. 2023

Pharmaceutics

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Gold nanorods (AuNRs) have attracted attention in the field of biomedicine, particularly for their potential as photothermal agents capable of killing tumor cells by photothermic ablation. In this study, the synthesis of novel AuNRs stabilized with thiolated pectin (AuNR@SH-PEC) is reported. To achieve this, thiolated pectin (SH-PEC) was obtained by chemically binding cysteamine motifs to the pectin backbone. The success of the reaction was ascertained using FTIR-ATR. Subsequently, the SH-PEC was used to coat and stabilize the surface of AuNRs (AuNR@SH-PEC). In this context, different concentrations of SH-PEC (0.25, 0.50, 1.0, 2.0, 4.0, and 8.0 mg/mL) were added to 0.50 mL of AuNRs suspended in CTAB, aiming to determine the experimental conditions under which AuNR@SH-PEC maintains stability. The results show that SH-PEC effectively replaced the CTAB adsorbed on the surface of AuNRs, enhancing the stability of AuNRs without affecting their optical properties. Additionally, scanning electron and atomic force microscopy confirmed that SH-PEC is adsorbed into the surface of the AuNRs. Importantly, the dimension size (60 × 15 nm) and the aspect ratio (4:1) remained consistent with those of AuNRs stabilized with CTAB. Then, the photothermal properties of gold nanorods were evaluated by irradiating the aqueous suspension of AuNR@SH-PEC with a CW laser (808 nm, 1 W). These results showed that photothermal conversion efficiency is similar to the photothermal conversion observed for AuNR-CTAB. Lastly, the cell viability assays confirmed that the SH-PEC coating enhanced the biocompatibility of AuNR@SH-PEC. Most important, the viability cell assays subjected to laser irradiation in the presence of AuNR@SH-PEC showed a decrease in the cell viability relative to the non-irradiated cells. These results suggest that AuNRs stabilized with thiolated pectin can potentially be exploited in the implementation of photothermal therapy.

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A review of the role of carbon nanotubes for cancer treatment based on photothermal and photodynamic therapy techniques

Cited by 34 publications

References 85 publications

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Novel Gold Nanorods@Thiolated Pectin on the Killing of HeLa Cells by Photothermal Ablation

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