The detailed China Fusion Engineering Test Reactor (CFETR) 22.5° computer aided design (CAD) model is very difficult to convert into Monte Carlo N Particle Transport Code (MCNP). Manually writing MCNP input data is complicated, which is not only time-consuming but also cannot guarantee accuracy. Therefore, in order to improve the efficiency and accuracy of model transformation, modeling with CAD using CATIA is introduced, and MCNP files are converted by ANSYS. This is because ANSYS has a function that converts CAD “stp” format to MCNP input in the geometry section. Meanwhile, ANSYS can also reverse the converted MCNP input file to inspect which module has the problem. Compared with the software platform that can automatically cut, although the CATIA-to-ANSYS method is inferior in terms of automatic operation, it has advantages in accuracy and quickly dealing with error modules. Moreover, it can also perform parametric modeling in CATIA, which facilitates the optimization of the blanket structure. In this paper, the detailed CFETR 22.5° model was developed, and then parametric modeling of the blanket based on CATIA was performed. Finally, a detailed neutronics model is obtained by ANSYS transformation and inspection. Some representative models were initially validated by comparing volume changes before and after conversion. Then, the final neutronics model was used to calculate the nuclear analyses, including the neutron wall loading, fast neutron flux, and nuclear heating on the inboard side. The results show that the volume of the transformed model is basically consistent with the original model, and the error of results is small.