A review on albumin as a biomaterial for ocular drug delivery

Tiwari, Rahul; Sethiya, Neeraj Kumar; Gulbake, Anamika Sahu; Mehra, Neelesh Kumar; Murty, Upadhyayula Suryanarayana; Gulbake, Arvind

doi:10.1016/j.ijbiomac.2021.09.112

Cited by 36 publications

(25 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A globular heart-shaped “Bovine serum albumin (BSA)” is a simple and cost-effective protein with appealing properties, including biodegradation and biocompatibility, which has been extensively reported for drug delivery and extended for therapeutic and medicinal uses, including ocular distribution [ 1 , 2 , 3 , 4 , 5 ]. It is one component of the tissue-culture media, and a scaffold based on albumin should work well for cell and tissue engineering because it can provide structural support [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Mehwish

Lee

2022

Gels

View full text Add to dashboard Cite

For porous protein scaffolds to be employed in tissue-engineered structures, the development of cost-effective, macroporous, and mechanically improved protein-based hydrogels, without compromising the original properties of native protein, is crucial. Here, we introduced a facile method of albumin methacryloyl transparent hydrogels and opaque cryogels with adjustable porosity and improved mechanical characteristics via controlling polymerization temperatures (room temperature and −80 °C). The structural, morphological, mechanical, and physical characteristics of both porous albumin methacryloyl biomaterials were investigated using FTIR, CD, SEM, XRD, compression tests, TGA, and swelling behavior. The biodegradation and biocompatibility of the various gels were also carefully examined. Albumin methacryloyl opaque cryogels outperformed their counterpart transparent hydrogels in terms of mechanical characteristics and interconnecting macropores. Both materials demonstrated high mineralization potential as well as good cell compatibility. The solvation and phase separation owing to ice crystal formation during polymerization are attributed to the transparency of hydrogels and opacity of cryogels, respectively, suggesting that two fully protein-based hydrogels could be used as visible detectors/sensors in medical devices or bone regeneration scaffolds in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Mehwish

Lee

2022

Gels

View full text Add to dashboard Cite

show abstract

“…In addition, in vivo comparison of the biodistribution in posterior ocular tissues in rabbits revealed increased retention in the retina due to encapsulation in the nanosystem rather than with a solution of model drug [ 135 , 136 ]. Albumin is widely used in the preparation of ocular nanosystems [ 137 ]. In a recent study, bovine serum albumin nanoparticles loaded with apatinib were prepared for the treatment of diabetic retinopathy.…”

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

“…Moreover, rapid clearance remains a challenge for nanosystems as they need to release their payload before being eliminated from the eye. Many studies focus on assessing the distribution in various tissues once the formulation has been instilled into the eye [ 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 134 , 137 , 138 , 139 ]. Unfortunately, few studies focus on assessing how mechanisms including blinking, tear drainage and ocular metabolism may interact with nanosystems [ 66 , 115 ].…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

View full text Add to dashboard Cite

The greatest challenge associated with topical drug delivery for the treatment of diseases affecting the posterior segment of the eye is to overcome the poor bioavailability of the carried molecules. Nanomedicine offers the possibility to overcome obstacles related to physiological mechanisms and ocular barriers by exploiting different ocular routes. Functionalization of nanosystems by fluorescent probes could be a useful strategy to understand the pathway taken by nanocarriers into the ocular globe and to improve the desired targeting accuracy. The application of fluorescence to decorate nanocarrier surfaces or the encapsulation of fluorophore molecules makes the nanosystems a light probe useful in the landscape of diagnostics and theranostics. In this review, a state of the art on ocular routes of administration is reported, with a focus on pathways undertaken after topical application. Numerous studies are reported in the first section, confirming that the use of fluorescent within nanoparticles is already spread for tracking and biodistribution studies. The first section presents fluorescent molecules used for tracking nanosystems’ cellular internalization and permeation of ocular tissues; discussions on the classification of nanosystems according to their nature (lipid-based, polymer-based, metallic-based and protein-based) follows. The following sections are dedicated to diagnostic and theranostic uses, respectively, which represent an innovation in the ocular field obtained by combining dual goals in a single administration system. For its great potential, this application of fluorescent nanoparticles would experience a great development in the near future. Finally, a brief overview is dedicated to the use of fluorescent markers in clinical trials and the market in the ocular field.

show abstract

“…Polymer nanoparticles are also useful for delivering drugs to hard-to-reach tissues and organs. For instance, they can facilitate drug permeation to challenging anatomic structures, such as the inner ear [241][242][243][244], retina [245][246][247][248][249], brain [250][251][252][253][254], and avascular connective tissues [255][256][257].…”

Section: Drug Deliverymentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

View full text Add to dashboard Cite

Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

show abstract

A review on albumin as a biomaterial for ocular drug delivery

Cited by 36 publications

References 103 publications

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Polymer-Based Nanosystems—A Versatile Delivery Approach

Contact Info

Product

Resources

About