A Review on Analytical Methods for Ivabradine determination in Pharmaceutical Dosage Forms

Abstract

Ivabradine is a specific heart rate lowering agent, acting by reducing the rate of pacemaker activity in the sinoatrial node. Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. In multicenter clinical trials, it has been proved that Ivabradine is superior to beta-blocking agents during complex therapy of chronic heart failure accompanied with its beneficial effects related to cardiac remodeling, improvement of the currency of heart failure and diminution of patients rehospitalisation. It is suggested that Ivabradine as a newer agent is a valuable perspective drug for the treatment of congestive heart failure. This review is useful for the future study for researcher involved in formulation development and quality control of Ivabradine. This review article represents the various analytical methods which have been reported for estimation of Ivabradine in pharmaceutical dosage form. The spectrophotometric techniques and Q-absorbance ratio method were reported by the various authors. Many researchers also worked in chromatographic areas like Thin layer chromatography, High performance liquid chromatography, and High performance thin layer chromatography. Ivabradine is also studied by various hyphenated techniques .We reviewed and reported almost all analytical methods with more emphasis on chromatographic mrthodsfor Ivabradine.

FTIR-spectrophotometric analysis of levosulpiride and its pharmaceutical formulations

“…Literature survey reveals that various method for analysis of levosulpiride including HPTLC, 6 HPLC 7 and UV spectrophotometer. [8][9] But this method proves to be more complex and is uneconomical. Here we propose an additional method for the quantification of Levosulpiride in bulk as well as formulation by Fourier Transform Infrared spectrophotometer using Zinc -Selenide crystal ATR method, which is simpler and produce accurate results.…”