A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

Moghadamtousi, Soheil Zorofchian; Kadir, Habsah Abdul; Hassandarvish, Pouya; Tajik, Hassan; AbuBakar, Sazaly; Zandi, Keivan

doi:10.1155/2014/186864

Cited by 894 publications

(696 citation statements)

References 90 publications

(109 reference statements)

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“…The increased size of chitosan-coated liposomes may be due to the rearrangement of the chitosan coating on the surface. Another noteworthy fact is that, the chitosan-coated liposomes can be stored for a longer period that the uncoated ones since possible antifungal or microbial effect on the liposomes may be ruled out owing to the fact that chitosan has established antimicrobial properties [46,47]. …”

Section: Discussionmentioning

confidence: 99%

Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation

Huang

Muhemaitia

2018

Libyan Journal of Medicine

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Cataract is the leading cause of blindness globally with surgery being the only form of treatment. But cataract surgery is accompanied by complications, chiefly intra-ocular infections. Hence, preventive nanoformulations may be extremely beneficial. In the present study, novel chitosan-coated liposomal formulations encapsulating a combination of drugs, lanosterol and hesperetin were prepared and characterized. The combinatorial liposomes were prepared by thin film evaporation active extrusion method. The characterization of liposomes was done by transmission electron microscopy, zeta potential, encapsulation efficiency, stability, cytotoxicity and in vitro release studies. The main difference between the chitosan-coated and uncoated combinatorial liposomes is the release of drugs as indicated by the in vitro release studies. The slow and sustained release of the drugs from chitosan-coated ones as against the burst release from uncoated indicates an increased retention time for combinatorial drugs in cornea. This leads to a delay in progression of cataract as seen from in vivo studies. Cytotoxicity studies indicate no cell toxicity of the coating of chitosan or the combination of drugs. Stability studies indicate that there were almost no changes in size, zeta potential and polydispersity index values of the combinatorial liposomes upon storage at room temperature for 60 days. Another important study is the estimation of antioxidant defense system. The estimated values of glutathione reductase, malondialdehyde and chief antioxidant enzymes point toward an upregulation of antioxidant defense system. From the results, it may be concluded that novel chitosan-coated combinatorial liposomes are effective in delaying or preventing of cataract.

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Section: Discussionmentioning

confidence: 99%

Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation

Huang

Muhemaitia

2018

Libyan Journal of Medicine

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“…[10][11][12] Curcumin (CUR) has a long history of therapeutic use in Indian and Chinese medicine and has several pharmacological properties, including antioxidant, anti-inflammatory, antiviral, antimicrobial, antifungal, as well as anticancer activities. 13 CUR has attenuated several types of organ injury (lung, renal, hepatic, heart, and ovary) in different I/R models.…”

Section: Introductionmentioning

confidence: 99%

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

et al. 2016

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Curcumin and dexmedetomidine have been shown to have protective effects in ischemia-reperfusion injury on various organs. However, their protective effects on kidney tissue against ischemia-reperfusion injury remain unclear. We aimed to determine whether curcumin or dexmedetomidine prevents renal tissue from injury that was induced by hind limb ischemia-reperfusion in rats. Fifty rats were divided into five groups: sham, control, curcumin (CUR) group (200 mg/kg curcumin, n ¼ 10), dexmedetomidine (DEX) group (25 lg/kg dexmedetomidine, n ¼ 10), and curcumin-dexmedetomidine (CUR-DEX) group (200 mg/kg curcumin and 25 lg/kg dexmedetomidine). Curcumin and dexmedetomidine were administered intraperitoneally immediately after the end of 4 h ischemia, just 5 min before reperfusion. The extremity re-perfused for 2 h and then blood samples were taken and total antioxidant capacity (TAC), total oxidative status (TOS) levels, and oxidative stress index (OSI) were measured, and renal tissue samples were histopathologically examined. The TAC activity levels in blood samples were significantly lower in the control than the other groups (p < 0.01 for all comparisons). The TOS activity levels in blood samples were significantly higher in Control group and than the other groups (p < 0.01 for all comparison). The OSI were found to be significantly increased in the control group compared to others groups (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in the sham, CUR, DEX, and CUR-DEX groups, compared with the control group (p < 0.01). Rat hind limb ischemia-reperfusion causes histopathological changes in the kidneys. Curcumin and dexmedetomidine administered intraperitoneally was effective in reducing oxidative stress and renal histopathologic injury in an acute hind limb I/R rat model. ARTICLE HISTORY

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“…Its antimicrobial activity has been widely reported in literature. 9 Curcumin (diferuloylmethane with chemical name of (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)) is the main ingredient of turmeric. It is highly potent, nontoxic and bioactive.…”

Section: Introductionmentioning

confidence: 99%

“…It is highly potent, nontoxic and bioactive. Curcumin has been found to be an effective antibacterial agent against bacteria such as Bacillus subtilis, B. macerans, B. licheniformis, and Azotobacter 10 and Staphylococcus aureus, Salmonella paratyphi.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Nanoformulations as Potential Antimicrobial Agent

Tyagi

Farooqi

2017

JBMOA

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Turmeric has been widely used as antimicrobial agent in Asian countries for centuries. The demand for a safe and reliable antimicrobial agent has increased world over due to the side effects of existing drugs and the development of newer drug-resistant microbes. Curcumin, the active ingredient of turmeric, has come up as a potential solution to these problems. This research article summarizes the recent developments in the field of curcumin nanoformulations and their applications as antimicrobial agent.

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A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

Cited by 894 publications

References 90 publications

Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation

Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

Curcumin Nanoformulations as Potential Antimicrobial Agent

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