Curcumin Nanoformulations as Potential Antimicrobial Agent

Tyagi, Sonia; Farooqi, Javed A.

doi:10.15406/jbmoa.2017.05.00149

Cited by 2 publications

(1 citation statement)

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“…Recent spreading of microbial infections, and emergence of new pathogens including multidrug resistant species are considered humanity challenges that brings a need of alternative therapies 1 . Public interest in traditional herbs has developed due to their confirmed medical properties and limited or no side effects 2 .…”

Section: Introductionmentioning

confidence: 99%

Molecular modeling study of micro and nanocurcumin with in vitro and in vivo antibacterial validation

Othman

Shamekh²,

Abdalla

et al. 2023

Sci Rep

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Repurposing natural compounds as inhibitory targets to combat bacterial virulence is an important potential strategy to overcome resistance to traditional antibiotics, in the present study, the antibacterial activity of micro-curcumin and nano-sized curcumin was investigated against four predominant bacterial pathogens, namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. Curcumin bactericidal susceptibility could be summarized as the order, P. aeruginosa > B. subtilis > S. aureus > E. coli. Molecular docking analysis was conducted to confirm the impact of curcumin on the most vital and positively identified quorum-sensing pathway signaling proteins SecA-SecY, LsrR, PqsR (MvfR), AgrA which act as key players in the bacterial communication systems. The in silico physicochemical properties revealed that curcumin as a nutraceutical can be classified as a drug-like compound. An in vivo infected wound model was employed in four groups of albino rats. Topical application of nano-curcumin lotion showed a marked reduction in wound area (98.8%) as well as nearly 100% reduction in total bacterial viable count compared to the control group, on the fifteenth day post-treatment post-injury. The obtained data suggested that curcumin nanoparticles exhibited superior antibacterial activity and may possess clinical utility as a novel topical antimicrobial and wound healing agent.

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Section: Introductionmentioning

confidence: 99%