Nanofluid lubrication and machining are challenging and significant tasks in manufacturing industries that are used to control the removal of a material from a surface by using a cutting tool. The introduction of a nanofluid to the cutting zone provides cooling, lubricating, and chip-cleaning benefits that improve machining productivity. A nanofluid is a cutting fluid that is able to remove excessive friction and heat generation. Chemical reactions and temperature-dependent density are essential in the thermal behavior of a nanofluid. The present study presents a careful inspection of the chemical reactions, temperature-dependent density, viscous dissipation, and thermophoresis during the heat and mass transfer of a nanofluid along a magnetically driven sheet. The physical attitude of viscous dissipation and the chemical reaction improvement rate in magneto-nanofluid flow is the primary focus of the present research. By applying the proper transformation, nonlinear partial differential expressions are introduced to the structure of the ordinary differential framework. The flow equations are simplified into nonlinear differential equations, and these equations are then computationally resolved via an efficient computational technique known as the Keller box technique. Flow factors like the Eckert number, reaction rate, density parameter, magnetic force parameter, thermophoretic number, buoyancy number, and Prandtl parameter governing the velocity, temperature distribution, and concentration distribution are evaluated prominently via tables and graphs. The novelty of the current study is in computing a heat transfer assessment of the magneto-nanofluid flow with chemical reactions and temperature-dependent density to remove excessive friction and heating in cutting zones. Nanofluids play significant roles in minimum quantity lubrication (MQL), enhanced oil recovery (EOR), drilling, brake oil, engine oil, water-miscible cutting fluids, cryogenic cutting fluids, controlled friction between tools and chips and tools and work, and conventional flood cooling during machining processes.