A review on biological sources, chemistry and pharmacological activities of pinostrobin

Abstract

Pinostrobin, a dietary bioflavonoid discovered more than 6 decades ago in the heart-wood of pine (Pinus strobus), has depicted many pharmacological activities including anti-viral, anti-oxidant, anti-leukaemic, anti-inflammatory and anti-aromatase activities. It is an inhibitor of sodium channel and Ca(2+) signalling pathways and also inhibits intestinal smooth muscle contractions. In spite of the fact that pinostrobin has an application as functional foods, till-to-date no comprehensive review on pinostrobin has been carried out. Hence, the present review deals with the biological sources, chemistry and pharmacological activities of pinostrobin.

TLC determination of some flavanones in the buds of different genus Populus species and hybrids

“…Among the flavonoids identified in the analyzed poplar buds, the contents of two, pinostrobin and pinocembrin, were determined. This was due to their confirmed antioxidant and anti-inflammatory properties, which might be responsible for medicinal efficacy of poplar buds (14,15). Two evaluation modes for quantitative analysis of flavanones, densitometric and videodensitometric, were employed.…”

“…Flavonoids can play an important role in the pharmacological effects of poplar buds in terms of their antioxidant and anti-inflammatory properties. Among Populus constituents, two flavanones, pinostrobin and pinocembrin, revealed interesting antioxidant and antiinflammatory activities (14,15).…”

Cytochrome P450 reaction phenotyping and inhibition and induction studies of pinostrobin in human liver microsomes and hepatocytes

“…Pinostrobin is a natural flavonoid that exerts diverse bioactivities, including antioxidant (Wei et al, 2013), antimicrobial (Dzoyem et al, 2012) and anti-inflammatory activities (Patel, Jaiswal, & Bhutani, 2015), the induction of quinone reductase activity (Fahey & Stephenson, 2002) and virus protease inhibition (Heh et al, 2013). This compound also substantially induced the activities of mammalian phase II detoxification enzymes and antioxidant enzymes (Fahey & Stephenson, 2002).…”

Two new sesquiterpene glycosides isolated from the fresh needles of Pinus massoniana Lamb.

“…Recent pharmacological studies revealed that the needles of P. massoniana possess antioxidant (Chen et al 2014), antibacterial , cardiovascular protection (Wang et al 2008), lipid regulation (Zheng et al 2010), and antitumour (Zheng et al 2009) properties. Up to now, volatile oil (Yatagai & Hong 1997), lignans (Lundgren et al 1985), flavonoids Patel et al 2016), shikimate (Ma et al 2008), proanthocyanidins (Gao et al 2011;Shen et al 2010) and their derivatives were isolated from P. massoniana. In our phytochemical investigation, two new sesquiterpene glycosides, compounds 1 and 2, were isolated from the title plant.…”