A Review on Biomarkers in Clinical Osteoporosis - Significance of Hydroxyproline

Abstract

Osteoporosis is a chronic disorder in both men and women, where it decreases the bone quality and quantity, which may lead to a fall in bone mass density. It mostly occurs because of reduced peak bone mass or excessive formation or resorption during bone remodeling. Various degradation products of bone collagen are pyridinoline (Pyr), deoxypyridinoline, N-terminal telopeptides, and hydroxyproline (Hyp), which are excreted in the urine. Among that, Hyp is a crucial biomarker used to correlate osteoporosis condition. An overview of all the biomarkers and the signed note of Hyp with different analytical methods are provided in the current piece of work. To quantify amounts in biological samples, various methods have been developed for Hyp analysis, such as the colorimetric technique, gas chromatography, gas chromatography-mass spectrometry, and widely used high-performance liquid chromatography tests to detect the concentration of Hyp in different matrices. This review states the importance of biomarkers and Hyp's significance for detecting osteoporosis, clinical manifestation, and different analytical methods for Hyp. The study indicates that hydroxyproline is a unique biomarker used to detect osteoporosis. It is also showing the clinical manifestation of osteoporosis and discussed different analytical methods for hydroxyproline.

Osteoporosis de los huesos maxilares

“…Protocolos de detección de osteoporosis en entornos dentales: Integrar la detección de osteoporosis en las evaluaciones dentales de rutina puede identificar pacientes en riesgo y derivarlos para evaluaciones adicionales. Los dentistas pueden utilizar cuestionarios, evaluaciones clínicas e imágenes dentales para identificar indicadores de osteoporosis y referir a los pacientes para pruebas de densidad ósea cuando sea necesario (5,27).…”