A review on controlled porosity osmotic pump tablets and its evaluation

Sahoo, Chinmaya Keshari; Sahoo, Nalini Kanta; Rao, Surepalli Ram Mohan; Sudhakar, M.; Satyanarayana, Kokkula

doi:10.1016/j.bfopcu.2015.10.004

Cited by 22 publications

(11 citation statements)

References 25 publications

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“…The fact that part of the mannitol remained in the powder form allowed the manufacture of highly porous matrix printlets with fast disintegrating properties. Additionally, mannitol is an osmotic agent [57], the presence of the osmotic sugar in the formulation, may allow the printlet to rapidly imbibe water into its core generating an internal pressure that can break apart the sintered bridges. Formulation I showed larger sintered areas due to the higher content of Kollidon VA-64 ( Figure 2A).…”

Section: Resultsmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

148

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The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

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Section: Resultsmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

148

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“…The semi-permeable membrane or film in osmotic pump systems must be sufficiently rigid so as to retain its dimensional integrity during the operational lifetime of the devices [22] . The mechanical properties of the films were measured by tensile strength and percentage of elongation.…”

Section: Resultsmentioning

confidence: 99%

Effect of Polyethylene Glycol on Cellulose Acetate Films Designed for Controlled Porosity Osmotic Pump Systems

Tonglairoum¹,

Pitaktunskul²,

Ngawhirunpat³

et al. 2019

pharmaceutical-sciences

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Generally, drug release from controlled release oral dosage forms would be affected by pH, gastrointestinal motility and the presence of food in gastrointestinal tract. Osmotic controlled-release oral delivery system, which utilizes osmotic pressure as the driving force for controlled delivery of active agent(s), however is not influenced by these factors, and it is possible to predict the release characteristics from the known properties of the drug and the dosage form [1][2][3] . The simplest design of elementary osmotic pump consists of an osmotic core (comprising a drug with or without an osmogent) coated with a semi-permeable membrane. After coming in contact with the gastrointestinal fluids [4,5] , it absorbs water at a rate determined by the fluid permeability of the membrane and osmotic pressure of core formulation. This osmotic imbibitions of water results in the formation of a saturated solution of drug within the core, which is dispensed at a controlled rate from the delivery orifice in the membrane [6,7] . In addition, there are numerous factors that affect the drug release from osmotic pumps (i.e. drug solubility, osmotic pressure, delivery orifice and types or characteristics of the film). The membrane permeability is one of the important factors that need to be concerned when designing the system because the delivery of drug from oral osmotic systems is controlled by the influx of solvent across the semipermeable membrane, which in turn carries the agent to the outside environment [2,8] . Water influx into basic osmotic pump system can be described by the following Eqn. [3] , dv/dt = A×Lp×(σ∆π-∆P)/h, where dv/dt is water influx, A and h are the film area and thickness, respectively; Lp is mechanical

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“…Pre compression parameters of osmotic pump tablets [11] Angle of repose θ: The angle of repose was determined by the funnel method. The accurately weighed powder blend was taken in a funnel.…”

Section: Evaluation Of Controlled Porosity Osmotic Pump Tabletsmentioning

confidence: 99%

Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Lamivudine using Sodium Chloride as Osmogen for the Treatment of AIDS

Sahoo¹,

Sahoo²,

Rao³

et al. 2018

Madridge J Nov Drug Res

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The present study was undertaken to develop controlled porosity osmotic pump tablets of lamivudine a nucleoside reverse transcriptase inhibitor for the treatment of acquired immune deficiency syndrome (AIDS). The tablets were prepared by wet granulation method using HPMC E5LV, and osmogen was prinicipal ingredients a dose of 300 mg once daily. The coating solution of core tablets were prepared by using cellulose acetate, poly ethylene glycol of different grades, sorbitol and acetone to quantity sufficient for different batches. The prepared tablets were evaluated for pre compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among developed formulations LS4 batch show 98.26% drug release in 12 hrs. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon Crowell model. The results of optimized formulation follow Higuchi kinetics and which is independent of the pH and agitation intensity. Short term stability study (at 40 ± 2°C/75 ± 5% RH for three months) on the best formulation indicated that there was no significant changes in thickness, friability, weight variation, drug content and in vitro drug release.

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A review on controlled porosity osmotic pump tablets and its evaluation

Cited by 22 publications

References 25 publications

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Effect of Polyethylene Glycol on Cellulose Acetate Films Designed for Controlled Porosity Osmotic Pump Systems

Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Lamivudine using Sodium Chloride as Osmogen for the Treatment of AIDS

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