A Review on Coronavirus Disease and Potentially Active Drugs Targeting Coronavirus

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus with single positive-strand RNA, having glycoproteins projection on envelopes so reveals a halo-like appearance or corona. Coronavirus is of four types: (1) α-coronavirus (α-COV); (2) β-coronavirus (β-COV); (3) δ-coronavirus (δ-COV); and (4) γ-coronavirus (γ-COV) and belongs to family Coronaviridae and subfamily Coronavirinae. Coronaviruses are the normal pathogens that cause broad band of gastrointestinal and respiratory diseases in domestic as well as wild animals such as pigs, birds, and rodents. Coronavirus is highly infectious in case of elders for mortality rate. The elder peoples are at 2-fold higher risk as compared to the younger population and the greater part of the population dying from coronavirus disease (COVID-19) is male. The virus enters into the body by the mouth, eyes, or nose, then particles march inside of the body by different pathways and affect vital organs in severe ways such as liver, heart muscle, blood vessels, kidneys, central nervous system, etc. Right now, the only solution to avoid COVID-19 infection is “precautions.” Different companies of different countries at different steps are in race to develop effective medicines for treatment and management of the same. Here, in this review, we tried to give an overview of all about SARS-CoV-2, COVID-19 infection, pathophysiology, mechanisms, and various treatment trials.

Synthesis, crystal structure, potential drug properties for Coronavirus of Co(II) and Zn(II) 2-chlorobenzoate with 3-cyanopyridine complexes

“…With the pandemic, people had to take some disposable precautions, such as masks, visors, overalls, with the guidance of some authorities. Many researchers continue to work for both treatment and permanent prevention [28] , [29] , [30] . Today, drug materials synthesized for use in drug therapy for many viral diseases such as Herpes and HIV are limited.…”

Kobalt(II) 4-Floro- ve 4-Bromobenzoat Nikotinamid Komplekslerinin Hirshfeld Yüzey Analizi, Etkileşim Enerjisi Hesaplamaları ve Koronavirüs Spike Proteini ile Etkileşimlerinin Moleküler Docking Çalışmaları ile İncelenmesi

“…Günümüzde, birçok viral hastalık için ilaç tedavisinde kullanılan ilaç materyalleri sınırlıdır. Pandeminin başlangıcından bu yana SARS-CoV-2 tedavisinde kullanılan ilaçların bazıları halen kullanımdayken bazılarının kullanımı durdurulmuştur (Fakhar et al, 2021;Jain et al, 2021;Rothan & Byrareddy, 2020;Verma et al, 2021). Hesaplamalı yöntemler, hem yapısal özelliklere ilişkin hem de ilaç araştırmaları için hipotezler sunar.…”