A review on CXCR4/CXCL12 axis in oncology: No place to hide

Domańska, Urszula; Kruizinga, Roeliene C.; Nagengast, Wouter B.; Timmer‐Bosscha, Hetty; Huls, Gerwin; Vries, Elisabeth G.E. de; Walenkamp, Annemiek

doi:10.1016/j.ejca.2012.05.005

Cited by 544 publications

(482 citation statements)

References 68 publications

Supporting

Mentioning

457

Contrasting

Unclassified

Order By: Relevance

“…A noteworthy example is CXCR4, a receptor of stromal cell-derived factor 1 (SDF1; also known as CXCL12). CXCR4 is expressed on many cancer cells, and SDF1 is a nichederived chemoattractant for CXCR4 + cells, thereby enhancing their entry into the bone marrow 64 . These observations have led to the development of clinically effective drugs that inhibit CXCR4-SDF1 interactions 65,66 and that may be used to mobilize CSCs and possibly to sensitize them to therapy 67 .…”

Section: Csc Niche: Definition and Open Questionsmentioning

confidence: 99%

“…These observations have led to the development of clinically effective drugs that inhibit CXCR4-SDF1 interactions 65,66 and that may be used to mobilize CSCs and possibly to sensitize them to therapy 67 . Conversely, CSCs often exhibit an acquired defect in their interaction with their specific microenvironments, leading to an abnormal or accelerated dissemination and metastasis formation 64 . CSC-niche interactions may also contribute to the acquisition of more aggressive properties by cells in solid tumours through the promotion of a response referred to as an epithelial-to-mesenchymal transition (EMT).…”

Section: Csc Niche: Definition and Open Questionsmentioning

confidence: 99%

See 1 more Smart Citation

Cancer stem cell definitions and terminology: the devil is in the details

Valent

Bonnet

Maria³

et al. 2012

Nat Rev Cancer

625

564

View full text Add to dashboard Cite

| The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients. PERSPECTIVES NATURE REVIEWS | CANCER VOLUME 12 | NOVEMBER 2012 | 767

show abstract

Section: Csc Niche: Definition and Open Questionsmentioning

confidence: 99%

Section: Csc Niche: Definition and Open Questionsmentioning

confidence: 99%

Cancer stem cell definitions and terminology: the devil is in the details

Valent

Bonnet

Maria³

et al. 2012

Nat Rev Cancer

625

564

View full text Add to dashboard Cite

show abstract

“…In China, bladder tumors are the most common among all urogenital cancer tumor types and their incidence is on the rise (Raghavan, 2012). According to numerous studies on the invasive mechanisms of tumor metastasis, chemokine receptors and their ligands play important roles in mediating the invasion and metastasis of malignant tumors (Dobner et al, 2012;Domanska et al, 2013). In the current study, we targeted the chemokine receptor CXCR4 and its ligand CXCL12, and investigated their protein and gene expressions using the immunohistochemistry (IHC) methods and reverse-transcriptase polymerase chain reaction (RT-PCR), respectively, in cancerous and normal bladder tissues, and analyzed their clinical significance.…”

Section: Introductionmentioning

confidence: 99%

Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer

Yang¹,

Xin²,

Wang³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT.It is well known that chemokine receptors and their ligands play important roles in mediating the invasion and metastasis of malignant tumors. This aim of this study was to investigate the expression and clinical significance of chemokine receptor CXCR4 and its ligand CXCL12 in bladder tumor tissues. Cancerous and adjacent normal bladder tissues were collected from 42 patients. The expressions of CXCR4 and CXCL12 proteins were then detected by immunohistochemistry, and the expressions of CXCR4 and CXCL12 mRNAs were detected by RT-PCR. Bladder cancer tissues showed higher positive expressions of CXCR4 and CXCL12 than those in normal bladder mucosal tissues (z = 7.332, 6.758, P < 0.001). Positive expressions of CXCR4 and CXCL12 were related to the differentiation degree and invasive depth of cancer tissues (z = 2.598-4.594, P < 0.05), but not to patient gender or age (z = 0.273-0.554, P > 0.05). The expression of CXCR4 was positively correlated to CXCL12 expression in bladder cancer tissues (r = 0.661, P < 0.05). RT-PCR revealed that CXCR4 and CXCL12 mRNAs were not expressed in normal tissues. Moreover, with increased depth of invasion, CXCR4 and CXCL12 mRNA expressions gradually increased in bladder cancer tissues 17699-17707 (2015) and showed significant intergroup differences (F = 56.642, 67.928, P < 0.01). Taken together, these results indicate that the chemokine receptor CXCR4 and its ligand CXCL12 play important roles in the occurrence and development of bladder cancer.

show abstract

“…13) In another study, a high level of CXCR4 expression was noted in these patients, which reacted with CXCL12 and activated PI3K to accelerate migration, engraftment, and proliferation of cancer cells. 14) Thus, it is considered that Exon 21 L858R mutation-positive cases are likely to become pleural lavage cytology-positive due to activation of the CXFR4-CXCL12 pathway.…”

Section: Discussionmentioning

confidence: 99%

Epidermal Growth Factor Receptor Gene Mutation in Pleural Lavage Cytology Findings of Primary Lung Adenocarcinoma Cases

Inoue

Matsumura

Araki

et al. 2018

ATCS

View full text Add to dashboard Cite

Purpose: In the present study, we examined the relationship between intraoperative pleural lavage cytology findings and presence of epidermal growth factor receptor (EGFR) gene mutations. Methods: We investigated 160 patients who underwent surgical treatment for primary lung adenocarcinoma at our hospital from January 2011 to December 2013 to determine the presence of EGFR gene mutations and pleural lavage cytology. Results: In all, 52 subjects (31.5%) were positive EGFR gene mutations, of whom 38 were found to possess the Exon 21 L858R mutation. Intraoperative pleural lavage cytology examinations were performed in 160 subjects and 12 had positive results, of whom 6 were positive for EGFR gene mutations, which was the Exon 21 L858R mutation in all. In a comparison between subjects possessing the Exon 21 L858R mutation and those negative for EGFR gene mutations, lavage cytology-positive (p = 0.02) and vascular infiltrationnegative (p = 0.01) were characteristics of the Exon 21 L868R mutation-positive group. Conclusion: Subjects positive for the EGFR Exon 21 L858R mutation had a higher positive rate of intraoperative pleural lavage cytology than those not possessing EGFR mutations.

show abstract

A review on CXCR4/CXCL12 axis in oncology: No place to hide

Cited by 544 publications

References 68 publications

Cancer stem cell definitions and terminology: the devil is in the details

Cancer stem cell definitions and terminology: the devil is in the details

Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer

Epidermal Growth Factor Receptor Gene Mutation in Pleural Lavage Cytology Findings of Primary Lung Adenocarcinoma Cases

Contact Info

Product

Resources

About