A Review on Diverse Role of Heterocyclic Moieties Containing Aminoquinoline and Azoles

Abstract

Article InfoOver past few decades, the problems posed by multi-drug resistant microbes have reached an alarming level in many countries around the world. The use of most antimicrobial agents is limited not only by rapidly developing drug resistance but also by the unsatisfactory treatment of microbial infections. In pursuit of this goal, our research efforts are focused on the development of novel structural moieties with diverse activities. Literature survey revealed that various heterocyclic members such as pyrazole, imidazole, triazole, thiadiazole, thiazole are predominantly imperative antibacterial and antifungal agents including azoles derivatives like tazobactam, cefatrizine, rufinamide, fluconazole, itraconazole, voriconazole, posaconazole and ketoconazole.