A Review on Medicinal Plants Used for Improvement of Spermatogenesis

Khojasteh, Seyed Mahdi Banan; Khameneh, Reihaneh Javanmard

doi:10.4172/0974-8369.1000292

Cited by 19 publications

(17 citation statements)

References 82 publications

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“…The increases were consistent with anthocyanin reduction of oxidative stress caused by heat exposure and maintenance of spermatogenic cells by inhibition of enzyme damage to maintain normal spermatogenesis. Increased epithelium thickness has been associated with increased numbers of Sertoli and spermatogenic cells [15]. The antioxidant activity of anthocyanin has been attributed to the donation of a single electron to oxidant molecules and thus increasing the number of spermatozoa [16].…”

Section: Resultsmentioning

confidence: 99%

Effects of a standardized 40% ellagic acid pomegranate (Punica granatum L.) extract on seminiferous tubule histopathology, diameter, and epithelium thickness in albino Wistar rats after heat exposure

et al. 2019

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Background and Aim: It has long been known that the spermatogenic tissue is very sensitive to temperatures higher than its physiologic temperature and causing cessation of activity and resulting in sterility. This study investigated the effect of a standardized 40% ellagic acid extract of pomegranate on the histopathology, diameter, and epithelial thickness of seminiferous tubules in albino rats exposed to heat. Materials and Methods: Twenty-five male albino Wistar rats were randomized at 7-8 months of age to five treatment groups. Group C was not treated; Group T0 was treated with 0.5% of Na carboxymethyl cellulose (CMC) 2 ml/day and exposed to heat. T1, T2, and T3 were treated with 75, 150, and 300 mg/kg/day of a standardized 40% ellagic acid extract of pomegranate (Punica granatum L.), respectively. The animals were orally administered Na CMC or pomegranate extract and were exposed to sunlight for 15 min at 40°C-42°C for 14 days. The animals were sacrificed on day 15 and the testes were removed for histological evaluation and measurement of seminiferous tubule diameter and epithelium thickness. Results: The diameter of seminiferous tubules from rats exposed to heat and treated with 300 mg/kg/day pomegranate extract was larger and the epithelia thicker than those in the other groups (p= <0.05). The protective effects of the standardized 40% ellagic acid extract may have been mediated by its antioxidant activity. Conclusion: Compared with controls, administration of 300 mg/kg/day of a standardized 40% ellagic acid extract of P. granatum L. for 14 days increased seminiferous tubule diameter and epithelium thickness in albino Wistar rats exposed to heat. Keywords: diameter, epithelium thickness, heat, pomegranate extract, seminiferous tubule.

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Section: Resultsmentioning

confidence: 99%

Effects of a standardized 40% ellagic acid pomegranate (Punica granatum L.) extract on seminiferous tubule histopathology, diameter, and epithelium thickness in albino Wistar rats after heat exposure

et al. 2019

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“…Several phytomedicines, including phenolic compounds (phenolics, sterols, lignans, and flavonoids), volatile oils, and saponins, are found in dietary supplements. They have been shown to increase sperm parameters (sperm motility, count and viability) and have positive effects on spermatogenesis (Khojasteh et al, 2016;Adewoyin et al, 2017). Also, previous study have reported that the fractions of S. androgynus leaves can increase the weight of testicular and seminal vesicle (Rusdi et al, 2018).…”

Section: Resultsmentioning

confidence: 97%

Evaluation of sperm quality in male rats treated with Sauropus androgynus (L.) merr. leaf fractions

2020

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Sauropus androgynus (L.) Merr. or katuk is one of the medicinal plants broadly used in Indonesia as it has active compounds that can, among others, stimulate reproductive hormones. This study was aimed to determine which active fraction of S. androgynus leaves that have the potential to improve the sperm quality of male rats based on three parameters, namely sperm count, viability, and motility. It employed fractionation using the liquid-liquid extraction with n-hexane, ethyl acetate, and water solvents to obtain the fractions. Twenty-four mature Sprague-Dawley male rats were divided into four equal groups: the normal group (untreated group) received 0.5% Na-CMC suspense, and the three fraction groups were given the n-hexane, ethyl acetate, and water fraction p.o., respectively, at the dose of 11.85 mg.Kg-1 BW daily for seven days. Sperm count, viability, and motility were measured on day 8 (after treatment) from the sperm samples collected at the cauda epididymis of the sacrificed test rats. The results showed that compared with the normal group, the n-hexane and ethyl acetate fractions significantly increased the three parameters (p<0.05). Therefore, the S. androgynus leaf fractions have the potential as a natural material that can increase the fertility of male rats.

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“…Fertility and implantation activity of plant extracts found to be related to oestrogenic activity in males, while in females resulted from their action as estrous cycle disruptors in an animal laboratory (20,(46)(47)(48). Prior studies suggest that flavonoids may positively affect fertility activity by improving spermatogenesis (49,50). The lack of consistency in findings can be attributed primarily to the presence of many classes of flavonoid compounds (e.g.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Potential Anti-Fertility Activity of Arbutus Pavarii in Male Mice

Alghazeer¹,

Elgahmasi²,

Aljazzaf³

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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A Review on Medicinal Plants Used for Improvement of Spermatogenesis

Cited by 19 publications

References 82 publications

Effects of a standardized 40% ellagic acid pomegranate (Punica granatum L.) extract on seminiferous tubule histopathology, diameter, and epithelium thickness in albino Wistar rats after heat exposure

Effects of a standardized 40% ellagic acid pomegranate (Punica granatum L.) extract on seminiferous tubule histopathology, diameter, and epithelium thickness in albino Wistar rats after heat exposure

Evaluation of sperm quality in male rats treated with Sauropus androgynus (L.) merr. leaf fractions

Investigation of the Potential Anti-Fertility Activity of Arbutus Pavarii in Male Mice

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