A Review on Nanocochleates: The Inimitable Nanoparticulate Drug Carriers

Bhosale, Rohit R.; Gangadharappa, H.V.; Gowda, D. V.; Osmani, Riyaz Ali M.; Vaghela, Rudra

doi:10.1166/asem.2017.2020

Cited by 30 publications

(30 citation statements)

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“…It has the same microstructure as the parent cubic phase but differ in having larger specific surface area and their dispersions have much lower viscosity in comparison to the bulk cubic phase 9 .…”

Section: Figure 1: Chemical Structure Of Rebamipidementioning

confidence: 99%

Formulation and Characterization of Cubosomes Containing REB for Improvement of Oral Absorption of the Drug in Human Volunteers

Hashem

Nasr

Youssif

2018

Journal of Advanced Pharmacy Research

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Objective: To prepare rebamipide (REB) -loaded cubosomal nanoparticles to improve the oral bioavailability of the drug in human volunteers. Methodology: The poorly water soluble drug REB was incorporated into cubosomal nanoparticles by solvent dilution method. The prepared REB-loaded cubosomes were in vitro characterized for particle size, polydispersity index (PDI), zeta potential, drug crystallinity and in vitro drug release. In vivo absorption of REB-loaded cubosomes was compared with drug powder and commercially available tablets Mucosta ® (Egypt Otsuka Pharmaceutical Company) in healthy human volunteers. Results: In vitro, REB-loaded cubosomes entrapped about 82.44 % drug and revealed nanometer-size ranged from 303.1 ± 4.9 to 444.9 ± 6 nm. In vitro REB release from cubosomes exhibited a phase of rapid and high release of the drug during the first hour followed by a slower and complete drug release over a period of 3 hrs. The results of bioavailability study in healthy human volunteers showed that cubosomes significantly improved the rate and extent of REB absorption. The mean relative bioavailability of the REB loaded cubosomes compared to the drug powder and commercially available tablets (Mucosta ® ) was 267.67 % and 166.29 % respectively. Conclusion: The prepared cubosomes significantly improved the In-vivo absorption of REB in comparison with drug powder and commercially available tablets (Mucosta ® ).

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Section: Figure 1: Chemical Structure Of Rebamipidementioning

confidence: 99%

Formulation and Characterization of Cubosomes Containing REB for Improvement of Oral Absorption of the Drug in Human Volunteers

Hashem

Nasr

Youssif

2018

Journal of Advanced Pharmacy Research

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“… providing an optimistic approach for bioavailability enhancement for poorly-water soluble drugs [7,8].…”

Section: Introductionmentioning

confidence: 99%

Cubosomes: composition, preparation, and drug delivery applications.

Gaballa

Garhy

Abdelkader

2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Cubosomes can be considered as a novel lipid-based nanosystems similar to well-known vesicular systems such as liposomes and niosomes. Cubosomes have been widely formulated using certain amphiphilic lipids (e.g. glyceryl monooleate and phytantriol) in the presence of a suitable stabilizer. They can represent a novel drug delivery system which could be loaded with hydrophilic, lipophilic and amphiphilic drug molecules. They are widely used for various drug delivery applications such as oral, ocular, transdermal and chemotherapy drug delivery. In this review, the pertinent literature of cubosomes with emphasis on theories of self-assembling, the composition of cubosomes, methods of preparation and drug delivery applications will be critically reviewed. Key words Cubosomes, glycerol monooleate (GMO), phytantriol (PHYT), poloxamer 407, theories of self-assembling  They have low entrapment efficiency for water-soluble drug molecules due to their high water content inside their structure [1]. 2. Theories of self-assembling of amphiphilic lipids Certain amphiphilic surfactants with polar and non-polar components are able to self-assemble in aqueous media into highly ordered aggregates (structures) [16], with long-range order in one, two or three dimensions and short-range order at atomic distance [17]. The resultant surfactant structures could be micelles, open lipid bilayer, closed lipid bilayer and inverted micelles. There are two main theories tried to explain how these surfactant can be self-assembled into especial structure. 2.1. The principle of opposing forces Amphiphilic molecules when exposed to a polar solvent they are arranged in such a way to minimize their free energy, where the polar solvent penetrates through the amphiphilic molecules exposing the hydrophilic portions to the aqueous environment

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“…They have ability to encapsulate hydrophilic, hydrophobic, and amphiphilic substances. Cubosomes have relatively simple preparation methods; they render bioactive agents with controlled and targeted release, possess lipid biodegradability, and have high internal surface area with different drug-loading modalities [ 127 , 128 ]. Cubosomes are an attractive choice for cosmeceuticals, so for this reason a number of cosmetic giants are investigating cubosomes.…”

Section: Novel Nanocarriers For Cosmeceuticalsmentioning

confidence: 99%

Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances

Kaul

Gulati

Verma

et al. 2018

Journal of Pharmaceutics

236

212

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Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use. Novel nanocarriers like liposomes, niosomes, nanoemulsions, microemulsion, solid lipid nanoparticles, nanostructured lipid carrier, and nanospheres have replaced the usage of conventional delivery system. These novel nanocarriers have advantages of enhanced skin penetration, controlled and sustained drug release, higher stability, site specific targeting, and high entrapment efficiency. However, nanotoxicological researches have indicated concern regarding the impact of increased use of nanoparticles in cosmeceuticals as there are possibilities of nanoparticles to penetrate through skin and cause health hazards. This review on nanotechnology used in cosmeceuticals highlights the various novel carriers used for the delivery of cosmeceuticals, their positive and negative aspects, marketed formulations, toxicity, and regulations of nanocosmeceuticals.

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A Review on Nanocochleates: The Inimitable Nanoparticulate Drug Carriers

Cited by 30 publications

References 0 publications

Formulation and Characterization of Cubosomes Containing REB for Improvement of Oral Absorption of the Drug in Human Volunteers

Formulation and Characterization of Cubosomes Containing REB for Improvement of Oral Absorption of the Drug in Human Volunteers

Cubosomes: composition, preparation, and drug delivery applications.

Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances

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