A Review on Nanosponges a Review on Nanosponges: A Boon to Targeted Drug Delivery for Anticancer Drug

Sehgal, Nikita; N, Vishal Gupta; Kanna, Sandeep

doi:10.22159/ajpcr.2019.v12i7.33118

Cited by 4 publications

(2 citation statements)

References 73 publications

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“…After reaching a steady state, the suspension was centrifuged and filtered using a 3 000 Dalton molecular filter (MICRON YN 30, Millipore Corporation U. S. A). High-performance liquid chromatography was used to examine the resulting solution to determine the drug concentration [55].…”

Section: Solubility Studiesmentioning

confidence: 99%

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Sharma¹,

Sharma

Gupta³

2023

Int J App Pharm

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Recent advancements in nanotechnology have resulted in improved medicine delivery to the target site. Nanosponges are three-dimensional drug delivery systems that are nanoscale in size and created by cross-linking polymers. The introduction of Nanosponges has been a significant step toward overcoming issues such as drug toxicity, low bioavailability, and predictable medication release. Using a new way of nanotechnology, nanosponges, which are porous with small sponges (below one µm) flowing throughout the body, have demonstrated excellent results in delivering drugs. As a result, they reach the target place, attach to the skin's surface, and slowly release the medicine. Nanosponges can be used to encapsulate a wide range of medicines, including both hydrophilic and lipophilic pharmaceuticals. The medication delivery method using nanosponges is one of the most promising fields in pharmacy. It can be used as a biocatalyst carrier for vaccines, antibodies, enzymes, and proteins to be released. The existing study enlightens on the preparation method, evaluation, and prospective application in a medication delivery system and also focuses on patents filed in the field of nanosponges.

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Section: Solubility Studiesmentioning

confidence: 99%

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Sharma¹,

Sharma

Gupta³

2023

Int J App Pharm

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“…They can move in the body until they come across the exact target site and attach on the surface and start releasing the drug in a controlled manner 5,6 . In preparation of NS, cyclodextrins are the preferable polymer because these are having more capacity to increase the solubility of poorly soluble drugs when compared to other polymers.…”

mentioning

confidence: 99%

Untitled

2022

IJPSR

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The objective of the present study was to develop cyclodextrin-based nanosponge based topical gel of tazoretene using crosslinker diphenylcarbonate and Carbopol® Ultrez 10 NF polymer. The β-Cyclodextrin nanosponges were prepared using various concentrations of β-Cyclodextrin and diphenyl carbonate and characterized. Based on evaluation parameters the β-Cyclodextrin nanosponges formulations (NS2) displayed narrow particle size, sufficiently high particle size, and maximum solubilization efficiency. Tazarotene was loaded into five β-Cyclodextrin nanosponge formulations by freeze-drying method and evaluated. Owing to the better solubilization and drug loading capacity (45%) TZNS3 was selected for further studies. The particle size of 336 nm, the zeta potential of -23 mV, and maximum drug dissolution of 97%in 12h were displayed by TZNS3 hence formulated into a gel and evaluate. The optimized tazaroteneloaded nanosponge formulation (TZNS3) was incorporated into a model carbopol gel formulation and was evaluated for skin permeation and stability. The flux value for nanosponges based gel formulation (189.342 ± 3.879 μg cm −2 h −1 ) was found to be higher than that for plain tazarotene (106.765 ± 4.123 μg cm −2 h −1 ). Skin permeation studies demonstrated that the cumulative amount of tazarotene penetrating through the skin from gel formulation containing nanosponge encapsulated tazarotene was around 6 times more than that from gel formulation containing free tazarotene at 12 h. The results collectively suggest that because of the controlled drug release, better skin permeation, and good storage stability, cyclodextrin nanospongesbased gel formulation of tazarotene has tremendous potential to serve as a topical delivery system. INTRODUCTION:Nanoparticles are colloidal systems with particle sizes varying from 10 nm to 1000 nm. These are nano or sub-nano-sized structures which are made of synthetic or semisynthetic polymers. Nanoparticles of plant medicine are gaining a lot of attention currently.

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Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review

Dombe

Shirote

2021

CDT

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Cancer is the most ruinous disease globally. Natural products have impressive characteristics, such as excep-tional chemical versatility, chemical and biological properties of macromolecular specificity and less toxicity which make them good leads in finding novel drugs. The phytochemicals not only help to prevent but also treat chronic cancerous conditions. The present review attempts to put forth some selected anticancer phytochemicals that had reported omics char-acteristic and specifically suppressed cancer with in vitro and in vivo activity. Certain issues pertaining to anticancer phy-tochemicals like delivery to target site in the body and achieving controlled release in order to prevent overdoses havelong been a concern for medical researchers worldwide. The most conventional chemotherapy protocols for the treatment of cancer lead to adverse effects that limit biological efficacy and compromise patient outcomes. In order to defeat incompe-tency of current and upcoming natural anticancer agents and to attain targeted drug delivery with good efficacy and fewer side effects, there is a special focus on novel nanostructured particles and nano approaches consisting of carrier system. Recent studies have led to the discovery of mesoporous and nanoporous drug delivery mechanisms, such as inorganic or organic-based nanosponges. The metal based inorganic systems have exhibited toxicity and non-biodegradable character in vivo. As a result of problems related to inorganic systems, major shift of research from inorganic to organic nanosystems has occurred. About decades ago, researchers have developed organic nanosponges to control the limitation of drug delivery and cancer therapies. This review article discusses the development and application of nanosponges encapsulated phyto-chemicals for cancer therapy.

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A Review on Nanosponges a Review on Nanosponges: A Boon to Targeted Drug Delivery for Anticancer Drug

Cited by 4 publications

References 73 publications

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Untitled

Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review

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