A Review on Pancreatic Lipase Inhibitors from Natural Sources: A Potential Target for Obesity

Abstract

Background: Obesity is a worldwide lifestyle disorder and its incidence is growing at an alarming rate. Pancreatic lipase (PL) plays a key role in lipid metabolism and hence a potential target for obesity treatment. There have been reports that many bioactive compounds from natural sources are vast pool of PL inhibitors. Objective: In search of natural pancreatic lipase inhibitors, the review summarizes the potential of natural products for their pancreatic lipase inhibitory activity. Methods: In this review the data obtained from literature search across various electronic databases and journal article publications are reviewed. Results: The pancreatic lipase inhibitory activities of 61 biological sources were reviewed in this paper is backed by preclinical experimental evidence, either in vivo or in vitro. Conclusion: This article can be used as a ready to use reference for therapeutic lead molecules from plants, marine and insect derived natural products with PL inhibitory activity. The research is more focused on the discovery of more ingenious pancreatic lipase inhibitors with lesser consequences.

Phytochemical Profiling and Pancreatic Lipase Inhibitory Activity of <i>Flacourtia inermis</i> Roxb. Fruits

“…However, the activity was less potent than that of orlistat. Our literature review has shown that polar compounds are crucial for pancreatic lipase activity in selected plants 4,21 . And, ethanol is a polar solvent that can dissolve wide range of bioactive compounds.…”

“…There are published reports describing secondary metabolites derived from plants having lipase inhibitory activity, such as polyphenols, alkaloids, flavonoids, glycosides, saponins, terpenoids, carotenoids, and polysaccharides. As a result, safer and more efficient PL inhibitors are absolutely necessary for the treatment of obesity [4][5][6][7][8][9] .…”