A Review on Personalized Therapies

Abstract

Aims: Healthcare and pharmaceutical research are incessantly reaching to new zeniths which is substantiated by the increasing numbers of diagnostic and therapeutic options available to healthcare professionals for treating patients but a major impediment to this growth has been the evolution of genetic mutation that makes diagnosis and treatment an enigmatic job. Unfortunately, the study of etiology of mutations is still a very neonatal area of research due to the high number of different factors involved in cellular signal trafficking, several metabolic pathways and their simultaneous effects. Owing to these reasons it has been very difficult to select an appropriate treatment modality based on the manifestations of certain common mutations in a pack of symptoms especially in patients who are resistant to treatment. This has led to the development of personalized therapy which can be delineated as acclimatizing of medical treatment based on the characteristics of the individual being treated. This development leans on our understanding of how an individual ingrained molecular and genetic profile makes them prone to certain diseases. To discover a right target for personalized therapies a long screening proses along with In vivo and in vitro analysis are needed. To begin with this review is an attempt to summarize the information available for personalized therapies.