A review on photobioreactor design and modelling for microalgae production

Legrand, Jack; Artu, Arnaud; Pruvost, Jérémy

doi:10.1039/d0re00450b

Cited by 66 publications

(20 citation statements)

References 105 publications

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“…Many parameters influence productivity in a photobioreactor, amongst which are light absorption and its conversion efficiency (referred to as quantum yield) and the fluid hydrodynamics to enable good mixing and mass transfer of gaseous CO 2 and nutrients to cells, especially important in immobilised cell systems. A detailed description of all these aspects and their impact on photobioreractor productivity has been recently been published [230]. Effective light usage has been a particularly challenging problem in photobioreactors, especially in large scale system.…”

Section: Electromagnetic Fieldsmentioning

confidence: 99%

“…To mitigate the problems of the ineffective and non-uniform exposure of the cells to the light source, novel ways of introducing light energy are being developed. For example, the use of fibre optic probes that deliver the light from within rather than from the surface have been proposed as viable solutions [230,232,233]. Various designs of photobioreactors have also been proposed to eliminate light attenuation and maximise productivity.…”

Section: Electromagnetic Fieldsmentioning

confidence: 99%

See 1 more Smart Citation

Bioprocess intensification: A route to efficient and sustainable biocatalytic transformations for the future

Boodhoo

Flickinger

Woodley

et al. 2022

Chemical Engineering and Processing - Process Intensification

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Section: Electromagnetic Fieldsmentioning

confidence: 99%

Section: Electromagnetic Fieldsmentioning

confidence: 99%

Bioprocess intensification: A route to efficient and sustainable biocatalytic transformations for the future

Boodhoo

Flickinger

Woodley

et al. 2022

Chemical Engineering and Processing - Process Intensification

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“…One of the main important factors is light quantity and quality and its distribution in the reactor. Light attenuation inside the reactor also depends on many factors, with the thickness of the culture among the most important [9]. This is the reason for the design of the hybrid reactor: on the one hand, the diameter of the glass tube forming the spiral is theoretically optimal to avoid the culture from self-shading [53], but on the other hand, there is an automated light intensity adjuster, increasing light intensity in parallel with the increasing culture density.…”

Section: Growth Of the Culturesmentioning

confidence: 99%

“…Besides this, adequate mixing, sufficient gas supply, sterilizability, and adequate productivity should be maintained. Despite these difficulties, there are many experimental and a few industrially applied designs [8,9].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Photobioreactor Type on Biomass and Lipid Production of the Green Microalga Monoraphidium pusillum in Laboratory Scale

et al. 2022

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Mass production of microorganisms, algae among them, for new bioactive compounds and renewable innovative products is a current issue in biotechnology. The greatest challenge of basic research on this topic is to find the best solution for both physiology and scalability. In this study, the main goal was to highlight the contradictions of physiological and technological optimization in the same, relatively small, laboratory scale. The green alga Monoraphidium pusillum (Printz) Komárková-Legnorová was cultured in a conventional Erlenmeyer flask (as air bubbled in a tank-type photobioreactor) and in a hybrid (fermenter type + helical tubular type) photobioreactor of the same volume (2.8 L). Higher cell numbers from 1.7–2.3-fold, 2–2.8-fold higher dry masses, and 1.9–2.6-fold higher total lipid contents (mg·L−1) were measured in the tank reactor than in the hybrid reactor. Cultures in the conventional tank reactor were characterized with better nutrient utilization (42.8–77.7% higher phosphate uptake) and more diverse lipid composition than in the hybrid reactor. The study highlights that well-scalable arrangements and settings could be not optimal (or unsuitable in some cases) from a physiological point of view. The results suggest certain developmental directions for complex, well-scalable devices and highlight the importance of testing the gained physiological optima on these systems.

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“…Ultimately, the concept of generating bioenergy from microalgal biomass can only be economically feasible if other valuable co-products are utilized (Khanum et al 2020 ). Several recent papers have also discussed this challenge and proposed ways to overcome it, such as careful selection and optimization of strains (Kong et al 2019 ; Sproles et al 2021 ), optimized photobioreactor design (Deprá et al 2019 ; Tan et al 2020 ; Legrand et al 2021 ), and improved economical harvesting and processing methods (Li et al 2020 ; Liber et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Crossing and selection of Chlamydomonas reinhardtii strains for biotechnological glycolate production

Schad

Rössler

Nagel

et al. 2022

Appl Microbiol Biotechnol

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As an alternative to chemical building blocks derived from algal biomass, the excretion of glycolate has been proposed. This process has been observed in green algae such as Chlamydomonas reinhardtii as a product of the photorespiratory pathway. Photorespiration generally occurs at low CO2 and high O2 concentrations, through the key enzyme RubisCO initiating the pathway via oxygenation of 1.5-ribulose-bisphosphate. In wild-type strains, photorespiration is usually suppressed in favour of carboxylation due to the cellular carbon concentrating mechanisms (CCMs) controlling the internal CO2 concentration. Additionally, newly produced glycolate is directly metabolized in the C2 cycle. Therefore, both the CCMs and the C2 cycle are the key elements which limit the glycolate production in wild-type cells. Using conventional crossing techniques, we have developed Chlamydomonas reinhardtii double mutants deficient in these two key pathways to direct carbon flux to glycolate excretion. Under aeration with ambient air, the double mutant D6 showed a significant and stable glycolate production when compared to the non-producing wild type. Interestingly, this mutant can act as a carbon sink by fixing atmospheric CO2 into glycolate without requiring any additional CO2 supply. Thus, the double-mutant strain D6 can be used as a photocatalyst to produce chemical building blocks and as a future platform for algal-based biotechnology. Key Points • Chlamydomonas reinhardtii cia5 gyd double mutants were developed by sexual crossing • The double mutation eliminates the need for an inhibitor in glycolate production • The strain D6 produces significant amounts of glycolate with ambient air only

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A review on photobioreactor design and modelling for microalgae production

Abstract: A microorganism culture process is a complex system in which physical operating parameters and biological responses strongly interact. Mathematical formulation and modelling of the different phenomena involved in the process...

Cited by 66 publications

References 105 publications

Bioprocess intensification: A route to efficient and sustainable biocatalytic transformations for the future

Bioprocess intensification: A route to efficient and sustainable biocatalytic transformations for the future

The Effects of Photobioreactor Type on Biomass and Lipid Production of the Green Microalga Monoraphidium pusillum in Laboratory Scale

Crossing and selection of Chlamydomonas reinhardtii strains for biotechnological glycolate production

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