A Review on Physico-Chemical Parameters of Liposomal Doxorubicin

Abstract

The development of a generic liposomal doxorubicin product requires the study of critical physicochemical properties of the formulation. Food and Drug Administration (FDA) draft guideline has suggested few parameters to be tested for in vitro bioequivalence study which include liposomal composition, state of encapsulated drug, internal environment, liposomal morphology and number of lamellae, lipid bilayer phase transition, liposomal size distribution, grafted Polyethylene Glycol (PEG) at liposomal surface, electric surface potential or charge and in vitro leakage under multiple conditions. Characteristic features of components of liposomal doxorubicin formulation and detail of parameters to be studied have been discussed. This review compile specific, current and historical research outcomes on in vitro analysis of liposomal doxorubicin and highlights the important features that have a critical impact on properties of liposomal doxorubicin formulation. It will provide a better insight to the generic manufacturers and will help them to identify the critical quality attributes during the formulation development phase.

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn+2‐Pectinate Controlled‐Release Matrices

“…[30] Thus, PHM is widely exploited as promising pharmaceutical excipients in various drug delivery platforms. [23][24][25][26][27][28][29][30] The present study demonstrates the credibility of novel PHM-Zn þ2 -LM-pectinate controlled-release matrices for oral ACF delivery with Zn supplementation for effective RA treatment. Herein, ACF-loaded composite matrices were formulated by ionic-gelation technique and the effects of polymer-blend ratios and cross-linker concentrations on drug entrapment efficiency (DEE, %) and cumulative drug release at 10 h (Q 10 h , %) were studied.…”

An Updated Review of Stealth Liposomes and Its Ability to Evade the Immune System: A New Frontier in Cancer Chemotherapy

“…Hence, the undamaged automobiles are identified by the fluorescence. With the ACQ probes, several nanoparticles' in vivo fates have been studied, including those administered via various routes (such as oral, intravenous, transdermal, nasal, and ocular), micelles, nanoemulsions, and nanocrystals [126][127][128][129][130].…”

Mechanical properties and drug release rate of poly(vinyl alcohol)/poly(ethylene glycol)/clay nanocomposite hydrogels: Correlation with structure and physical properties

“…18 On the other hand, the nanoparticles in the hydrogel matrix decrease its porosity as evidenced by the SEM micrographs ( Figure 4) and could also play a barrier role against water molecules diffusion into the hydrogel, as the first step of hydrogel swelling. 19 Moreover, due to the interactions between the nanoparticles and the polymer chains in the hydrogel, the relaxation of the chains, as the second step of hydrogel swelling 20 could be more difficult. The latter effects of the nanoparticles could decrease the hydrogel swelling capacity.…”

“…The swelling mechanism of the system could be determined by the n value, so that n = 0.5, 0.5 < n < 1, and n = 1 are for a normal Fickian, non-Fickian, and type II diffusion mechanisms, respectively. 21,22,24 Also, by using equation below, the initial diffusion coefficient of water molecules for swelling of the system is calculated 19,21 :…”