A Review on Phytochemical Constituents and Pharmacological Activities of the plant: <i>Aerva lanata</i>

Singh, Sushila; Gowri, K.; Chitra,

doi:10.5958/0974-360x.2020.00286.3

Cited by 16 publications

(8 citation statements)

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“…As shown in some literature data, Aerva lanata (L.) Juss. is a phytochemical-rich plant [7,13,14]. Our previous research suggested that phenolic derivatives may be largely responsible for the observed biological activity of AL samples fractionated by liquid/liquid extraction.…”

Section: Resultsmentioning

confidence: 99%

“…contains a rich composition of secondary metabolites, e.g., alkaloids, sterols, and phenolic compounds. For example, the literature provides information about the presence of some flavonoid compounds in polpala, e.g., kaempferol, myricetin, apigenin, chrysin, rutin, quercetin, and isorhamnetin [5][6][7]. However, there is still no comprehensive research on phenolic secondary metabolites in the herb of A. lanata (L.) Juss.…”

Section: Introductionmentioning

confidence: 99%

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LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

et al. 2022

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The aim of the present study was to investigate the phenolic composition and the biological properties of different Aerva lanata (L). Juss. herb extracts obtained with the use of accelerated solvent extraction (ASE), i.e., a green, ecological method, for cosmetic purposes. All samples exhibited high DPPH• (9.17–119.85 mg TE/g) and ABTS•+ (9.90–107.58 mg TE/g) scavenging activity. The extracts exhibited considerable anti-lipoxygenase (EC50 between 1.14 mg/mL and 3.73 mg/mL) and anti-xanthine oxidase (EC50 between 1.28 mg/mL and 3.72 mg/mL) activities, moderate chelating activity (EC50 between 1.58 mg/mL and 5.30 mg/mL), and high antioxidant potential in the ORAC assay (0.36–3.84 mM TE/g). Changes in the polyphenol profile of the analysed samples depending on the solvent and temperature used for the extraction were determined with the liquid chromatography/electrospray mass spectrometry (LC-ESI-MS/MS) method. Twenty-one phenolic compounds, including flavonoids and phenolic acids, were detected and quantified. It was shown that tiliroside was one of the main phenolic metabolites in the A. lanata (L.) Juss. herb., which may suggest that this compound may be largely responsible for the observed anti-inflammatory activity of the extracts. In addition, the studied extracts exhibited promising skin-related (anti-tyrosinase, anti-elastase, anti-collagenase, and anti-hyaluronidase) activity. This study showed that Aerva lanata (L.) Juss. contains high amounts of phenolic compounds, including tiliroside, and has good skin-related activities. Therefore, the plant may be interesting as a novel source of bioactive agents for cosmetic industries.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

et al. 2022

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“…The plant is included in the Russia State Pharmacopoeia as a diuretic medicine. The herb is recommended for internal administration as a decoction [32,33].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss.

et al. 2021

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Many plants that are commonly used in folk medicine have multidirectional biological properties confirmed by scientific research. One of them is Aerva lanata (L.) Juss. (F. Amaranthaceae). It is widely used, but there are very few scientific data about its chemical composition and pharmacological activity. The aim of the present study was to investigate the chemical composition of phenolic acid (PA)-rich fractions isolated from methanolic extracts of A. lanata (L.) Juss. herb using the liquid/liquid extraction method and their potential antioxidant, anti-inflammatory, and anti-diabetic properties. The free PA fraction (FA), the PA fraction (FB) released after acid hydrolysis, and the PA fraction (FC) obtained after alkaline hydrolysis were analysed using liquid chromatography/electrospray ionization triple quadrupole mass spectrometry (LC-ESI-MS/MS). The phenolic profile of each sample showed a high concentration of PAs and their presence in A. lanata (L.) Juss. herb mainly in bound states. Thirteen compounds were detected and quantified in all samples, including some PAs that had not been previously detected in this plant species. Bioactivity assays of all fractions revealed high 2,2-diphenyl-1-picrylhydrazyl (DPPH•) (2.85 mM Trolox equivalents (TE)/g) and 2,2-azino-bis-3(ethylbenzthiazoline-6-sulphonic acid) (ABTS•+) (2.88 mM TE/g) scavenging activity. Fraction FB definitely exhibited not only the highest antiradical activity but also the strongest xanthine oxidase (XO) (EC50 = 1.77 mg/mL) and lipoxygenase (LOX)(EC50 = 1.88 mg/mL) inhibitory potential. The fraction had the best anti-diabetic properties, i.e., mild inhibition of α-amylase (EC50 = 7.46 mg/mL) and strong inhibition of α-glucosidase (EC50 = 0.30 mg/mL). The activities of all analysed samples were strongly related to the presence of PA compounds and the total PA content.

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“…The review also discusses the synthetic significance and toxicity of these plants. The study aims to comprehensively summarize what has already been done and what still needs to be done in future research related to Aerva species [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The pharmacological actions listed above are associated with the presence of valuable nutrients and biochemical compounds such as sterols/terpenes, flavonoids, alkaloids, phenols and sugars. The expedient use of substances obtained from this plant can increase the possibility of its use in medical practice [4,5,8].…”

Section: Introductionmentioning

confidence: 99%

Using the method of mathematical planning of the experiment in the development of a quality control method of aerva lanata l. herb

Abdullabekova¹,

Khaydarov²,

Sharipova³

et al. 2022

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Today, among the urgent tasks facing the pharmaceutical science of the Republic of Uzbekistan is the study of introduced medicinal plants. Of the promising plants Erva woolly - Aerva lanata Juss of the amaranth family (Amaranthaceae) deserves special attention. A perennial or biennial herbaceous plant grows in many countries of Africa, Saudi Arabia, India, Indonesia, etc. For the first time, Aerva lanata Juss. was introduced on the territory of the former USSR by the Transcaucasian zonal experimental station VILR (Kobuletti) in the mid-70s, then in Ukraine, Uzbekistan and Kazakhstan. Aerva lanata is a dioecious plant. The flowers of A. lanata are nectariferous. Pollination of Erva woolly occurs under the influence of gravity inside the flower, wind, insects and rainwater. Erva woolly with more than one pollination and seed dispersal mode is able to invade a variety of habitats with different environmental conditions and grow as widespread weeds. Among other Aerva species, A. lanata cultivar has a wide range of pharmacological activities such as sedative, antiulcer, antiasthma, antidiarrheal, antioxidant, antihyperglycemic, antimalarial, hypolipidemic and other activities. It is used as a diuretic, for acute kidney damage, as well as for ulcerative wounds, rheumatism. Given the availability of the raw material base necessary to meet the possible growth in consumer demand and its widespread use in traditional and scientific medicine to create effective, low-toxic drugs intended for the prevention and treatment of diseases of the urinary system, Aerva lanata Juss L. was chosen as the object of research. An important stage in the standardization of the final product is the quality control of the technological process and the raw materials entering the production to obtain the finished product. Particular attention is paid to the method of quantitative determination of one of the active substances or groups of biologically active substances that affect the therapeutic effect of finished pharmaceutical products. It is known that the quantitative determination of the active substance is carried out by its extraction from plant materials. In this regard, the problem arises - finding the optimal conditions for the process of extracting the active substance. In view of this, it becomes necessary to conduct research to determine the optimal conditions for the extraction process. The objective of the research: the use of the mathematical planning method of the experiment for the complete extraction of flavonoids from the herb Aerva lanata. To achieve this objective, the following tasks were defined: – selection of the mathematical planning method of the experiment; – selection of method for quantitative determination of flavonoids amount; – statistical analysis of the obtained results. Optimization of the process of extracting the amount of flavonoids from the herb of Aerva lanata, which is predominant in its raw materials, was carried out using the method of mathematical planning of experiments by Box and Wilson. The optimization problem was reduced to determining the values of technological parameters that ensure the maximum yield of total flavonoids from the plant. As an optimization parameter, Y was taken - the content of the sum of flavonoids in the extract, in % of its content in the raw material. Conclusion. This article presents the results of modeling and optimization of the process of obtaining the sum of flavonoids from the herb Aerva lanata Juss. L. A comprehensive quantitative assessment of the influence of three experimental factors (alcohol concentration, hydromodulus and extraction time) on the yield of the total flavonoids was carried out using the method of mathematical planning of the Box-Wilson experiment. The objective was achieved by building a mathematical model based on the first order regression equation: Y=1.20+0.185X1+0.091X2+0.111X3 The adequacy of this process is shown, a mathematical model and parametric identification of this model are presented. As a result of the statistical analysis of the obtained data, the following optimal conditions for the process of extracting the amount of flavonoids from the herb of Aerva lanata were revealed in the quantitative analysis of raw materials: alcohol concentration - 50%; hydromodule - 1:60; extraction time - 30 min. The maximum yield of the sum of flavonoids was 1.52% by weight of dry raw materials. The resulting mathematical model of the extraction process will allow further optimization of the extraction of compounds of natural origin, taking into account the quantitative influence of each factor.

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A Review on Phytochemical Constituents and Pharmacological Activities of the plant: Aerva lanata

Cited by 16 publications

References 0 publications

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss.

Using the method of mathematical planning of the experiment in the development of a quality control method of aerva lanata l. herb

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