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The stimulation or suppression of the immune response may modulate disease free state. Herbal medicine paved way for immunmodulation role in many mmunological disorder. The present study was aimed to prove the traditional claim on the theimmunomodulatory activity ofAvicenniaofficinalisagainst autoimmune diseases. TheAvicenniaofficinalis leaves was authentified and coarsely powdered then extracted successively with n-hexane,70% hydroalcohol followed by, ethylacetate. The phytoconstituentsofthe three extracts were analysed . Finally, all were subjected to (NBT) Nitrobluetetrazolium Assay, Candidacidal assay and Phagocytotic evaluation. The percentage yield and phytoconstituents of the extracts were determined. Among thethree extract, the ethanolic extract and Ethylacetateextractshowed effective immunomodulatory effect by their suppression of leucocytes and neutrophils. The results of the present study proved the immunomodulatory effect of Avicenniaofficinalis and further studies are essential to target this species against autoimmune diseases.

Nephrolithiasis appear to be a major health crisis among the population with serious medical related consequences throughout the lifetime of patient. The aim of the study was to evaluate the preventive effect of the hydro-alcoholic extract of A. lanata roots on Urolithiasis rats. Thirty adults male wistar Albino rats weighing 200 – 250 g were divided into five groups comprising 6 rats in each. Group I Served as positive control with water ad libitum. Group II as negative control which is disease treated group receiving 0.75% ethylene glycol mixed with drinking water for 28 days. Group III chosen as standard group receiving ethylene glycol for first 14 days and Cystone 750 mg/Kg from day 15 till day 28. Group IV and V received ethylene glycol for first 14 days and treatment regimen of LD (400 mg/Kg) and HD 800 mg/Kg orally from day 15 till day 28. Invitro studies like Nucleation, Aggregation and Growth assays were performed. Urine volume and pH was collected and observed for change in appearance, pH, odour and turbidity. Extract was given by preparing suspension and stability was observed by measuring its parameters. On Day 29, the kidneys were dissected and histopathology was done to check tubular injury. There was Increase in urine volume, enhanced excretion of urinary constituents like citrate, oxalate etc. and improving clearance rate. Improvement in pH and antioxidant activity was observed in treated groups. The extract showed that it has prominent effect on nephrolithiasis and has better safety profile in the dose given.