In-vitro Immunomodulatory Effect of HydroalcoholicLeaves Extract of Avicennia Officinalis

Abstract

The stimulation or suppression of the immune response may modulate disease free state. Herbal medicine paved way for immunmodulation role in many mmunological disorder. The present study was aimed to prove the traditional claim on the theimmunomodulatory activity ofAvicenniaofficinalisagainst autoimmune diseases. TheAvicenniaofficinalis leaves was authentified and coarsely powdered then extracted successively with n-hexane,70% hydroalcohol followed by, ethylacetate. The phytoconstituentsofthe three extracts were analysed . Finally, all were subjected to (NBT) Nitrobluetetrazolium Assay, Candidacidal assay and Phagocytotic evaluation. The percentage yield and phytoconstituents of the extracts were determined. Among thethree extract, the ethanolic extract and Ethylacetateextractshowed effective immunomodulatory effect by their suppression of leucocytes and neutrophils. The results of the present study proved the immunomodulatory effect of Avicenniaofficinalis and further studies are essential to target this species against autoimmune diseases.

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

“…[127] Leaf extracts of A. marina and A. officinalis were also detected for potential immunostimulatory and immunomodulatory activity, respectively. [128,129] The leaf and seed extract of C. decandra exhibited significant blood coagulation activity. [130] Similarly, significant anticoagulant activity was demonstrated by the leaf extract of L. racemosa.…”