A Review on Poloxamer and Hydroxy Propyl Methyl Cellulose Combination as Thermoresponsive Polymers in Novel Ophthalmic in Situ Gel Formulation and Their Characterization

Kurniawansyah, Insan Sunan; Rusdiana, Taofik; Sopyan, Iyan; Subarnas, Anas

doi:10.22159/ijap.2021v13i1.39697

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…Amphiphilic triblock copolymer molecules can form tiny micellar subunits in aqueous liquids. Above a certain concentration, critical micelle concentration that is known as the concentration of monomers at which micelles developed, and temperature, critical micellization temperature (CMT) that is known as the temperature below which amphiphile is present as unimer and unimers and lumps coexist above that, the polymer molecules assemble to form a large micellar crosslinked network [ 92 ]. Below CMT, both propylene and ethylene oxide units are hydrated, and propylene oxide is slightly soluble in aqueous solutions.…”

Section: Resultsmentioning

confidence: 99%

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Ibrahiem,

Shamma,

Salama

et al. 2023

Drug Deliv. and Transl. Res.

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Osteoarthritis is a bone and joint condition characterized pathologically by articular cartilage degenerative damage and can develop into a devastating and permanently disabling disorder. This investigation aimed to formulate the anti-inflammatory drug lornoxicam (LOR) into bile salt–enriched vesicles loaded in an in situ forming hydrogel as a potential local treatment of osteoarthritis. This was achieved by formulating LOR-loaded bilosomes that are also loaded with superparamagnetic iron oxide nanoparticles (SPIONs) for intra-muscular (IM) administration to improve joint targeting and localization by applying an external magnet to the joint. A 31.22 full factorial design was employed to develop the bilosomal dispersions and the optimized formula including SPION (LSB) was loaded into a thermosensitive hydrogel. Moreover, in vivo evaluation revealed that the IM administration of LSB combined with the application of an external magnet to the joint reversed carrageen-induced suppression in motor activity and osteoprotegerin by significantly reducing the elevations in mitogen-activated protein kinases, extracellular signal-regulated kinase, and receptor activator of nuclear factor kappa beta/osteoprotegerin expressions. In addition, the histopathological evaluation of knee joint tissues showed a remarkable improvement in the injured joint tissues. The results proved that the developed LSB could be a promising IM drug delivery system for osteoarthritis management. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Ibrahiem,

Shamma,

Salama

et al. 2023

Drug Deliv. and Transl. Res.

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“…Additionally, classical gel-forming agents (HPMC and sodium alginate) were considered auxiliary substances in concentrations preceding their critical concentration of gel formation. Hence, the three-dimensional gel structure they formed did not interfere with the reverse gel-sol transition of the composition [31,32].…”

Section: Discussionmentioning

confidence: 99%

New Biopharmaceutical Characteristics of In Situ Systems Based on Poloxamer 407

Бахрушина

NOVOZHILOVA

Shumkova

et al. 2023

Gels

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Thermosensitive systems based on poloxamer 407 are widely used in targeted drug delivery; however, the stability of the phase transition temperature remains insufficiently studied. This article presents the results of a study on the effect of adding polyethylene glycols (PEG) with different molecular weights and some classical gel-forming polymers on the gelation temperature of thermoreversible compositions based on poloxamer 407 in a long-term experiment. The study showed a positive effect of PEG addition with average molecular weights at concentrations of 1.5–2.0%, as well as gelling agents at a concentration below the critical gelation concentration. The proposed rheological test for studying the samples’ adhesion can give an indirect forecast of the composition adhesive rate. Based on the conducted studies, three experimental binary systems based on poloxamer 407 were selected, with the addition of HPMC 0.5%, sodium alginate 0.5%, and PEG 1500 1.5%. These systems are the most promising for the further development of in situ targeted drug delivery systems.

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“…[201] CODEN (USA): JDDTAO biomolecules and chemical assistants 32,33,34 . Structure of poloxamers 'shown in figure no 5.…”

Section: Polymers Used In the Instruction Of In-situ Gelmentioning

confidence: 99%

A Recent Overview: In Situ Gel Smart Carriers for Ocular Drug Delivery

Singh

Dev

Prasad

2021

J. Drug Delivery Ther.

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Delivery of the drug to the ocular area is blocked by the protective layers covering the eyes; it has always been a major problem to find effective bioavailability of the active drug in the ocular area due to the short duration of precorneal majority ocular stay. Direct delivery systems combine as well as oil, solution, and suspension, as a result, many delivery systems are not able to effectively treat eye diseases. Many works have been done and are being done to overcome this problem one of which is to use in-situ to build polymeric systems. Ocular In-situ gelling systems are a new class of eye drug delivery systems that are initially in solution but are quickly transformed into a viscous gel when introduced or inserted into an ocular cavity where active drugs are released continuously. This sol-to-gel phase conversion depends on a variety of factors such as changes in pH, ion presence, and temperature changes. Post-transplanting gel selects viscosity and bio-adhesive properties, which prolongs the gel's stay in the ocular area and also releases the drug in a long and continuous way unlike conventional eye drops and ointments. This review is a brief overview of situ gels, the various methods of in situ gelling systems, the different types of polymers used in situ gels, their gel-based methods, and the polymeric testing of situ gel. Keywords: In-situ gel, Polymers, and ion triggered in-situ gel, Mechanism, Evaluation parameters

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A Review on Poloxamer and Hydroxy Propyl Methyl Cellulose Combination as Thermoresponsive Polymers in Novel Ophthalmic in Situ Gel Formulation and Their Characterization

Cited by 9 publications

References 24 publications

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

New Biopharmaceutical Characteristics of In Situ Systems Based on Poloxamer 407

A Recent Overview: In Situ Gel Smart Carriers for Ocular Drug Delivery

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