A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

Kamoun, Elbadawy A.; Kenawy, El Refaie; Chen, Xin

doi:10.1016/j.jare.2017.01.005

Cited by 1,338 publications

(812 citation statements)

References 88 publications

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“…Hydrogel dressings have been shown to be superior to conventional dressings as they can maintain a moist environment which enhances wound healing [103]. Moreover, hydrogels can be employed as drug delivery systems along with anti-bacterial applications [103].…”

Section: Phytochemicals and Traditional Therapies In Wound Healingmentioning

confidence: 99%

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Shah

Amini-Nik

2017

IJMS

120

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Historically, plant-based products have been the basis of medicine since before the advent of modern Western medicine. Wound dressings made of honey, curcumin and other phytochemical-rich compounds have been traditionally used. Recently, the mechanisms behind many of these traditional therapies have come to light. In this review, we show that in the context of wound healing, there is a global theme of anti-inflammatory and antioxidant phytochemicals in traditional medicine. Although promising, we discuss the limitations of using some of these phytochemicals in order to warrant more research, ideally in randomized clinical trial settings.

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Section: Phytochemicals and Traditional Therapies In Wound Healingmentioning

confidence: 99%

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Shah

Amini-Nik

2017

IJMS

120

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“…Therefore, wound dressings come into being. The ideal wound dressing should possess suitable mechanical property, sufficient water vapor transmission rate (WVTR), exudate absorption capacity, good biocompatibility, excellent antimicrobial activity, and so on 2,3. However, commercial wound dressings rarely meet with the above conditions and are expensive 4.…”

Section: Introductionmentioning

confidence: 99%

“…Film dressings are always in advantages in good gases‐permeability and impermeable to bacteria and fluids, but can cause wound exudates accumulation and adherence to wound bed. Hydrogel dressings possess high exudates capacity and can easily be removed from wound, but sometimes exhibit poor mechanical stability and poor bacterial barrier 2–4. Thus, manufacturing an ideal wound dressing that combines the advantages of film dressings and hydrogel dressings in a simple way remains a great challenge for us.…”

Section: Introductionmentioning

confidence: 99%

Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Chen

Wang

Jian

et al. 2020

Macromolecular Bioscience

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Rapid absorption of wound exudate and prevention of wound infection are prerequisites for wound dressing to accelerate wound healing. In this study, a novel kind of promising wound dressing is developed by incorporating polyhexamethylene guanidine (PHMG)‐modified graphene oxide (mGO) into the poly(vinyl alcohol)/chitosan (PVA/CS) matrix, conferring the dressing the required mechanical properties, higher water vapor transmission rate (WVTR), less swelling time, improved antibacterial activity, and more cell proliferation compared to the PVA/CS film crosslinked by genipin. In vivo experiments indicate that the PVA/CS/mGO composite film can accelerate wound healing via enhancement of the re‐epithelialization. PVA/CS/mGO composite film with 0.5 wt% mGO sheets displays the best wound healing properties, as manifested by the 50% higher antibacterial rate compared to GO and the wound healing rate of the mouse using this dressing is about 41% faster than the control group and 31% faster than the pure PVA/CS dressing. The underlying mechanism of the accelerated wound healing properties may be a result of the improved antibacterial ability to eradicate pathogenic bacteria on the wound area and maintain an appropriate moist aseptic wound healing environment to accelerate re‐epithelialization. These findings suggest that this novel composite PVA/CS/mGO film may have promising applications in wound dressing.

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“…Polymeric hydrogels are excellent matrices for wound dressings because of their flexibility and hydrophilic nature, which allows them to provide an environment conducive to healing. Hydrogels are constructed though physical or chemical crosslinking of hydrophilic polymer networks, which results in soft materials that are often 80–90% water, or more (Kamoun, Kenawy, & Chen, ; Quarfoot, Hyla, & Patience, ). Thus, in wound healing applications, hydrogels can provide moisture to the wounds without causing further disturbance to the site (Quarfoot et al, ).…”

Section: Introductionmentioning

confidence: 99%

Temperature‐dependent structure and compressive mechanical behavior of alginate/polyethylene oxide–poly(propylene oxide)–poly(ethylene oxide) hydrogels

2019

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We report the structural and mechanical behavior of multicomponent hydrogels comprising the commercial poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) block copolymer F127 and alginate. Previous studies on this system have shown thermoreversible behavior in shear rheology. Here we explore the properties of these materials under compression and large deformations, relevant to applications such as wound dressings that require mechanical robustness. For gels with lower F127 concentration, we find that the stiffness of the gels can be ascribed to the alginate network, and that the Young's modulus and fracture stress do not strongly depend on temperatures. However, for gels with an F127 concentration of 30 wt %, the Young's modulus is enhanced at higher temperatures. Under large deformations, the fracture stress and fracture strain of the materials can be independently varied using the alginate and F127 concentrations, respectively; without the trade‐off in these properties that is often observed in rigid polymer networks. Small‐angle X‐ray scattering shows a power‐law dependence scattering intensity on q arising from the alginate network and scattering peaks consistent with rearranging micelles. For gels with lower F127 concentrations, we find a disordered–body‐centered cubic (BCC)‐face‐centered cubic (FCC) progression of states with temperature, and a BCC/FCC mixture for gels with higher F127 concentrations.

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A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

Abstract: Graphical abstract

Cited by 1,338 publications

References 88 publications

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Temperature‐dependent structure and compressive mechanical behavior of alginate/polyethylene oxide–poly(propylene oxide)–poly(ethylene oxide) hydrogels

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