A review on re-irradiation for recurrent and second primary head and neck cancer

Kasperts, N.; Slotman, Ben J.; Leemans, C. René; Langendijk, Johannes A.

doi:10.1016/j.oraloncology.2004.07.006

Cited by 90 publications

(86 citation statements)

References 58 publications

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“…Experienced radiotherapists who carefully followed their patients for many years find this to be an extremely rare possibility and irradiation should never be withheld from the patient for this reason. The best local control results for patients with previously irradiated recurrent head and neck cancers were reported to be with brachytherapy 30 . The reason for better local control was argued in the literature and reported that tumors with good prognostic factors (smaller tumors and oral cavity locations) were suitable for treatment with brachytherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The reason for better local control was argued in the literature and reported that tumors with good prognostic factors (smaller tumors and oral cavity locations) were suitable for treatment with brachytherapy. Moreover, higher radiation dose could be delivered by brachytherapy 30 . Our patient was previously received high-dose external beam radiation, tumor and we decided to deliver reirradiation with brachytherapy.…”

Section: Discussionmentioning

confidence: 99%

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Custom Made Mold Brachytherapy

Ersu¹

2012

Basal Cell Carcinoma

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Custom Made Mold Brachytherapy

Ersu¹

2012

Basal Cell Carcinoma

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“…However, complications of therapy such as xerostomia, dysphagia, and osteoradionecrosis can still adversely affect the QOL of long-term survivors. Despite these technological advances, approximately 30-83% of these patients still die due to persistent disease, locoregional recurrence, or second primary tumor, 21,37,39,57 hence local control of HNC continues to be a therapeutic challenge.…”

Section: -50%mentioning

confidence: 99%

Emerging applications of stereotactic radiotherapy in head and neck cancer

Truong

Grillone²,

Tschoe

et al. 2009

FOC

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Advances in the management of locally advanced head and neck cancer (HNC) have been focused on treatment intensification, including concomitant chemoradiotherapy, biological agents, and combining surgery with chemoradiotherapy. Despite these improvements, locoregional recurrence still constitutes the main pattern of treatment failure. As improvements in radiotherapy delivery and image-guided therapy have come to fruition, the principles of stereotactic radiosurgery are now being applied to extracranial sites, leading to stereotactic body radiotherapy. This article focuses on the emerging evidence for the use of stereotactic body radiotherapy for treatment of HNC as a boost after conventional external-beam radiotherapy, and also as reirradiation in recurrent or second primary HNC.

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“…The use of adjuvant therapy depends on a number of risk factors. Re-irradiation with or without chemotherapy is commonly reserved for inoperable recurrent locally advanced disease; as an adjunct or palliative treatment, this strategy is the only technique that may achieve long-term loco-regional Management of the N0 neck in recurrent laryngeal squamous cell carcinoma control and possibly prolong survival (15). Although a relatively high incidence of treatment-related complications has been reported, re-irradiation should be considered for patients in whom salvage surgery is not feasible (15).…”

Section: Introductionmentioning

confidence: 99%

“…Re-irradiation with or without chemotherapy is commonly reserved for inoperable recurrent locally advanced disease; as an adjunct or palliative treatment, this strategy is the only technique that may achieve long-term loco-regional Management of the N0 neck in recurrent laryngeal squamous cell carcinoma control and possibly prolong survival (15). Although a relatively high incidence of treatment-related complications has been reported, re-irradiation should be considered for patients in whom salvage surgery is not feasible (15). Therefore, re-irradiation with concurrent systemic therapy is recommended when: i) The sites of recurrence are not resectable; ii) the surgical margins are positive in the primary surgery; and iii) the patient has not previously undergone radiotherapy and their general condition is suitable for radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Management of the N0 neck in recurrent laryngeal squamous cell carcinoma

Jin

2015

Molecular and Clinical Oncology

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Abstract. The most effective therapeutic approach for the node-negative (N0) neck in patients with recurrent laryngeal squamous cell carcinoma (SCC) remains a subject of dispute. In the present study, the records of 163 patients with recurrent laryngeal SCC were retrospectively reviewed. All patients had a N0 neck at recurrence. At the time of recurrence, the N0 neck was managed using a wait-and-see strategy (observation group) or treatment (treatment group). A total of 125 (76.7%) patients accepted the wait-and-see strategy and 38 (23.3%) patients underwent treatments, including surgery, radiotherapy and/or chemotherapy. The Kaplan-Meier method with the computation of log-rank was used for analysis of survival. The t-test, χ 2 test or Fisher's exact test was used for comparisons of non-survival data in the groups. P<0.05 was considered to indicate a statistically significant difference in the two-sided tests. The 3-and 5-year overall survival rates after recurrence were 64.5 and 54.6% for the observation group, and 49.9 and 42.5% for the treatment group, respectively (P=0.011). The present study suggests that a wait-and-see policy is a satisfactory management option for the N0 neck in recurrent laryngeal SCC.

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A review on re-irradiation for recurrent and second primary head and neck cancer

Cited by 90 publications

References 58 publications

Custom Made Mold Brachytherapy

Custom Made Mold Brachytherapy

Emerging applications of stereotactic radiotherapy in head and neck cancer

Management of the N0 neck in recurrent laryngeal squamous cell carcinoma

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