A review on selected pharmacological activities of
            <i>Curcuma longa</i>
            L.

Jyotirmayee, B; Mahalik, Gyanranjan

doi:10.1080/10942912.2022.2082464

Cited by 76 publications

(37 citation statements)

References 105 publications

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“…Spices are highly utilized in food industries and therefore it is an important source of biologically active molecules that are referred to as nutraceuticals [ 27 ]. Among the various spices used, the Turmeric ( Curcuma longa ) is considered to be the most accepted one [ 28 , 29 ]. Apart from the C. longa , there are several other species that exist in the genus.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Biological Activities of the Leaf Essential Oils of Curcuma longa, Curcuma aromatica and Curcuma angustifolia

et al. 2022

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Curcuma species are widely used as a food additive and also in various medicinal purposes. The plant is a rich source of essential oil and is predominantly extracted from the rhizomes. On the other hand, the leaves of the plants are usually considered as an agrowaste. The valorization of these Curcuma leaf wastes into essential oils is becoming accepted globally. In the present study, we aim to extract essential oils from the leaves of Curcuma longa (LEO), C. aromatica (REO), and C. anguistifolia (NEO). The chemical composition of these essential oils was analyzed by GC-MS. Free radical scavenging properties were evaluated against the radical sources, including DPPH, ABTS, and hydrogen peroxide. The antibacterial activity was assessed by the disc diffusion method and Minimum inhibitory concentration analysis against Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica) bacteria. Results identified the compounds α-phellandrene, 2-carene, and eucalyptol as predominant in LEO. The REO was predominated by camphor, 2-bornanone, and curdione. The main components detected in NEO were eucalyptol, curzerenone, α-lemenone, longiverbenone, and α-curcumene. Antioxidant properties were higher in the LEO with IC50 values of 8.62 ± 0.18, 9.21 ± 0.29, and 4.35 ± 0.16 µg/mL, against DPPH, ABTS, and hydrogen peroxide radicals. The cytotoxic activity was also evident against breast cancer cell lines MCF-7 and MDA-MB-231 cells; the LEO was found to be the most active against these two cell lines (IC50 values of 40.74 ± 2.19 and 45.17 ± 2.36 µg/mL). Likewise, the results indicated a higher antibacterial activity for Curcuma longa essential oil with respective IC50 values (20.6 ± 0.3, 22.2 ± 0.3, 20.4 ± 0.2, and 17.6 ± 0.2 mm). Hence, the present study confirms the possible utility of leaf agrowastes of different Curcuma spp. as a possible source of essential oils with pharmacological potential.

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Section: Discussionmentioning

confidence: 99%

Chemical Composition and Biological Activities of the Leaf Essential Oils of Curcuma longa, Curcuma aromatica and Curcuma angustifolia

et al. 2022

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“…Curcumin is the most pivotal turmeric-based curcuminoid and is a popular yellow-colored Indian spice obtained from the rhizome part of Curcuma longa and corresponds to the ginger family (Hewlings and Kalman, 2017). Preclinical research has suggested curcumin to prevent or treat many disorders, such as colorectal cancer, cystic fibrosis, and inflammatory and neurological diseases (Jyotirmayee and Mahalik, 2022). Based Frontiers in Pharmacology frontiersin.org on phase I clinical data, an oral curcumin dosage of 8,000 mg/day has not resulted in any major adverse effects besides mild nausea and diarrhea.…”

Section: Curcuminmentioning

confidence: 99%

Natural product-based pharmacological studies for neurological disorders

Puri

Kanojia²,

Sharma³

et al. 2022

Front. Pharmacol.

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Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease.

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“…It has anti-microbial, anti-inflammatory, antioxidant and anti-cancer effects. [25][26][27][28] Nigella sativa contains volatile oil, phenolic acids, flavonoids, fixed oil, proteins, amino acids, reducing sugars, alkaloids, tannins, resins, glycosides, vitamins and minerals. Amongst the volatile oils, thymoquinone is the major compound present in it.…”

Section: Acute Oral Toxicity Testmentioning

confidence: 99%

Behavioral, Analgesic, Anti-Inflammatory and Acute Oral Toxicity Studies on Poly-Herbal Formulation with Anti-Oxidant and Anti-Cancer Effects

2022

TJNPR

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The study was aimed at carrying out pre-clinical studies on the poly-herbal formulation having evidence-based anti-oxidant and anti-cancer properties. The study involved the following preclinical studies on the poly herbal drug: behavioral studies were carried out at doses 50 mg and 100 mg/kg respectively using open field and light and dark methods; analgesic activity based on acetic acid induced writhing test was performed at 50 mg and 100 mg/kg doses of the extract; anti-inflammatory activity of the poly-herbal extract was conducted at the following doses: 10, 50, 100, and 150 mg/ml. Acute oral toxicity studies on the herbal extract were carried out at 5, 50, 300, 2000 and 5000 mg/kg doses. The results of pre-clinical studies carried out were comparable to the standards used endorsing the efficacy and safety of the herbal formulation under test. The efficacy and safety results of the activities carried out on the poly-herbal antioxidant and anti-cancer formulation by the researchers under test in this study and that of the already reported pharmacognostic, chemical, cytotoxic, anti-microbial and anti-oxidant results are suggestive of initiation of clinical studies on this supportive anti-oxidant and anti-cancer formulation.

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A review on selected pharmacological activities of Curcuma longa L.

Cited by 76 publications

References 105 publications

Chemical Composition and Biological Activities of the Leaf Essential Oils of Curcuma longa, Curcuma aromatica and Curcuma angustifolia

Chemical Composition and Biological Activities of the Leaf Essential Oils of Curcuma longa, Curcuma aromatica and Curcuma angustifolia

Natural product-based pharmacological studies for neurological disorders

Behavioral, Analgesic, Anti-Inflammatory and Acute Oral Toxicity Studies on Poly-Herbal Formulation with Anti-Oxidant and Anti-Cancer Effects

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