A review on the anti-carcinogenic and anti-metastatic effects of flax seed lignan secolariciresinol diglucoside (SDG)

Alphonse, P; Aluko, Rotimi E.

doi:10.15562/phytomedicine.2015.24

Cited by 18 publications

(12 citation statements)

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“…This would lead to an increase in the transcription of the estrogen responsive genes PS2, PGR and CD1 and subsequent proliferation of cancer cells [25]. It has been revealed that the most noticeable effect of SDG was to significantly reduce PS2 mRNA expression [26]. It is shown in two different in vivo models that lariciresinol, as one of the main dietary lignans, can inhibit mammary cancer growth in hormone responsive breast cancers [6].…”

Section: Discussionmentioning

confidence: 99%

Withdrawn: The Structural Bioinformatics Analysis of Biophenolic Lignan- Estrogen Receptor Interaction

Mohamadyar-Toupkanlou

Esfandiari

Kashef-Saberi

et al. 2017

CCDT

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Section: Discussionmentioning

confidence: 99%

Withdrawn: The Structural Bioinformatics Analysis of Biophenolic Lignan- Estrogen Receptor Interaction

Mohamadyar-Toupkanlou

Esfandiari

Kashef-Saberi

et al. 2017

CCDT

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“…However, more research activities, especially clinical and pharmacokinetic studies in humans, are required to corroborate this evidence. The focus on the roles of SDG and its metabolites in preventing breast tumors, including an evaluation of potential mechanisms of action, was reviewed by Alphonse and Aluko (2015).…”

Section: Anticarcinogenic Activity Of Pc From Fmmentioning

confidence: 99%

Biological activities of phenolic compounds extracted from flaxseed meal

et al. 2020

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Background: There is a worldwide demand for phenolic compounds (PC) because they exhibit several biological activities. The present investigation deals with a comprehensive study on the biological activities of phenolic compounds extracted from flaxseed meal (FM) with the aid of ultrasonic waves. Results:The antioxidant activity of the PC extract of FM is considerably high when measuring it by the three methods (the β-carotene coupled oxidation method, the DPPH free radical scavenging activity method, and measuring the reducing antioxidant power). The toxicity test revealed that the PC extract was nontoxic on normal retina cell line. Also, it has no anticoagulating activity. Evaluation of antimicrobial activity showed that it is effective towards four strains only from seven. FM phenolic extract has been evaluated as chemo-preventive agents by testing the product for any cytotoxic activity against human tumor cell lines. The highest inhibitory effect was achieved on cell lines of colon carcinoma and lung carcinoma with IC 50 = 22.3 and 22.6 μ/ml respectively. Conclusion: The PC extracted from FM showed high antioxidant activity, nontoxic on normal retina cell line, no anticoagulating activities, and an antimicrobial effect on some pathogenic bacteria, so the phenolic compounds extracted from flaxseed meal showed significant biological activities.

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“…Secoisolariciresinol and matairesinol are the two most well-known lignans [ 175 ]. Lignans have been shown to have chemopreventitive efficacy in breast and prostate cancers in humans [ 176 , 177 , 178 ]. Flaxseed supplementation of secoisolariciresinol (SDG) at 73, 147 or 293 μmol/kg, which is equivalent to 2.5%, 5% or 10% flaxseed diet, significantly reduced metastasis in a melanoma mice model where the percent of animals that had >50 lung tumors was reduced to 30%, 21%, and 22%, respectively, compared to the control (59%) [ 178 ].…”

Section: Polyphenols Role In Reversing Emt Mediated Cancer Metastamentioning

confidence: 99%

Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway

et al. 2017

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The epithelial-to-mesenchymal transition (EMT) has received significant interest as a novel target in cancer prevention, metastasis, and resistance. The conversion of cells from an epithelial, adhesive state to a mesenchymal, motile state is one of the key events in the development of cancer metastasis. Polyphenols have been reported to be efficacious in the prevention of cancer and reversing cancer progression. Recently, the antimetastatic efficacy of polyphenols has been reported, thereby expanding the potential use of these compounds beyond chemoprevention. Polyphenols may affect EMT pathways, which are involved in cancer metastasis; for example, polyphenols increase the levels of epithelial markers, but downregulate the mesenchymal markers. Polyphenols also alter the level of expression and functionality of important proteins in other signaling pathways that control cellular mesenchymal characteristics. However, the specific proteins that are directly affected by polyphenols in these signaling pathways remain to be elucidated. The aim of this review is to analyze current evidence regarding the role of polyphenols in attenuating EMT-mediated cancer progression and metastasis. We also discuss the role of the most important polyphenol subclasses and members of the polyphenols in reversing metastasis and targeting EMT. Finally, limitations and future directions to improve our understanding in this field are discussed.

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A review on the anti-carcinogenic and anti-metastatic effects of flax seed lignan secolariciresinol diglucoside (SDG)

Cited by 18 publications

References 0 publications

Withdrawn: The Structural Bioinformatics Analysis of Biophenolic Lignan- Estrogen Receptor Interaction

Withdrawn: The Structural Bioinformatics Analysis of Biophenolic Lignan- Estrogen Receptor Interaction

Biological activities of phenolic compounds extracted from flaxseed meal

Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway

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