A Review on the Medicinal Plant <i>Dalbergia odorifera</i> Species: Phytochemistry and Biological Activity

Son, Ninh The

doi:10.1155/2017/7142370

Cited by 45 publications

(26 citation statements)

References 69 publications

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“…Dalbergia odorifera is a predominantly outcrossing species [12]. Its flowers are entomophilous pollinated by small insects and fruits with flattened seedpods are dispersed by wind [59,60], which limits longer distance dispersal. Moreover, D. odorifera has the ability of coppice regeneration especially stimulated by trunk injuries [12].…”

Section: Genetic Diversity Of D Odoriferamentioning

confidence: 99%

Genetic Diversity of the Endangered Dalbergia odorifera Revealed by SSR Markers

Liu

Hong

et al. 2019

Forests

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Dalbergia odorifera T. Chen (Fabaceae) is a semi-deciduous tree species indigenous to Hainan Island in China. Due to its precious heartwood “Hualimu (Chinese)” and Chinese medicinal components “Jiangxiang”, D. odorifera is seriously threatened of long-term overexploitation and has been listed on the IUCN (International Union for Conservation of Nature’s) red list since 1998. Therefore, the elucidation of its genetic diversity is imperative for conservation and breeding purposes. In this study, we evaluated the genetic diversity of 42 wild D. odorifera trees from seven populations covering its whole native distribution. In total, 19 SSR (simple sequence repeat) markers harbored 54 alleles across the 42 samples, and the medium genetic diversity level was inferred by Nei’s gene diversity (0.36), observed (0.28) and expected heterozygosity (0.37). Among the seven wild populations, the expected heterozygosity (He) varied from 0.31 (HNQS) to 0.40 (HNCJ). The analysis of molecular variance (AMOVA) showed that only 3% genetic variation existed among populations. Moderate population differentiations among the investigated populations were indicated by pairwise Fst (0.042–0.115). Structure analysis suggested two clusters for the 42 samples. Moreover, the seven populations were clearly distinguished into two clusters from both the principal coordinate analysis (PCoA) and neighbor-joining (NJ) analysis. Populations from Haikou city (HNHK), Baisha autonomous county (HNBS), Ledong autonomous county (HNLD), and Dongfang city (HNDF) comprised cluster I, while cluster II comprised the populations from Wenchang city and Sansha city (HNQS), Changjiang autonomous county (HNCJ), and Wuzhisan city (HNWZS). The findings of this study provide a preliminary genetic basis for the conservation, management, and restoration of this endemic species.

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Section: Genetic Diversity Of D Odoriferamentioning

confidence: 99%

Genetic Diversity of the Endangered Dalbergia odorifera Revealed by SSR Markers

Liu

Hong

et al. 2019

Forests

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“…6,7,4′‐Trihydroxyflavone (THF) is a compound from the Dalbergia Odorifera (Leguminosae), which is called Jiangxiang in Chinese traditional medicine, and is a native tree growing in Hainan and Guangdong Provinces in China (Wang, Weng, & Cheng, ). D. odorifera is composed of arylbenzofuran, quinone, and fatty acids as well as major classes of flavonoids, phenols, and sesquiterpene derivatives (Ninh The, ). It is known as to treat blood stagnation syndrome, ischemia, swelling, necrosis, rheumatic pain, and epigastric pain in Korea and China (Lee et al, ).…”

Section: Introductionmentioning

confidence: 99%

6,7,4′‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo

Kim

Lee

et al. 2019

Phytotherapy Research

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The balance between the osteoblasts and the osteoclasts is important for the maintenance of the skeleton of the human body. The osteoclasts absorb bone after differentiated into polymorphonuclear cells by the fusion of monocytes/macrophages. We have found that 6,7,4′‐Trihydroxyflavone (THF), a compound from the heartwood of Dalbergia Odorifera inhibits receptor activator of NF‐κB ligand (RANKL)‐induced osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophage. THF significantly inhibited the c‐Jun‐N‐terminal kinase signaling pathway without affecting extracellular signal‐regulated kinase, p38, and AKT signaling. Moreover, THF inhibited the expression of c‐Fos, nuclear factor‐activated T cells cytoplasm 1, cathepsin K, and c‐src by RANKL. We used a lipopolysaccharide (LPS)‐induced bone loss model in mice. Consequently, bone volume per tissue volume, trabecular number's reduction was recovered in THF‐treated mice, and trabecular separation's augmentation was also attenuated by THF administration. In summary, THF inhibits RANKL‐induced osteoclast differentiation by MAPK signaling pathway and inhibits bone resorption by destroying the actin ring in mature osteoclasts. THF also prevented LPS‐induced bone loss in a mice model. Thus, THF may be useful in the treatment of bone diseases associated with excessive osteoclast differentiation and bone resorption.

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“…Dalbergia species has been considered as a valuable source of bioactive products, and the heartwood of these herbs has been used in traditional Chinese medicines for the treatment of several diseases, such as heart failure, myocardial fibrosis, myocardial infarction, myocarditis, and coronary failure [ 24 , 25 , 30 ]. To evaluate Dalbergia tonkinensis as a source of antidiabetic drugs, the heartwood of Dalbergia tonkinensis (HDT) was extracted with methanol; its inhibition against α-glucosidase was then tested.…”

Section: Resultsmentioning

confidence: 99%

“…Formononetinis is a soy isoflavonoid that was isolated from several medicinal plants, including Astragalus mongholicus (Bunge), Trifolium pretense L. (red clover), Butea monosperma [ 33 ], Euchresta formosana [ 34 ], root and heartwood of Dalbergia odorifera [ 25 ]. Formononetin has also been reported to demonstrate some beneficial activities of yeast α-glucosidase inhibition, as well as antibacterial, antioxidant, anti-inflammatory, and cytotoxicity activities [ 25 ], to exhibit estrogenic properties and to promote angiogenesis [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…This genus has been reported to possess numerous novel bioactivities, including: anti-cancer, antimicrobial, anti-inflammatory, analgesic, anti-diarrheal, cardiovascular, spermicidal, and antipyretic activities [ 24 ]. In particular, Dalbergia odorifera species has been extensively investigated for its numerous chemical constituents and various reported biological activities, including α-glucosidase inhibition [ 25 ]. In contrast, Dalbergia tonkinensis species, a medium-size floral species with a height of 5–13 m and widely distributed in Vietnam [ 26 ], and found in Hainan Island of China [ 27 ] has been poorly studied regarding its biological activities and chemical constituents.…”

Section: Introductionmentioning

confidence: 99%

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New Records of Potent In-Vitro Antidiabetic Properties of Dalbergia tonkinensis Heartwood and the Bioactivity-Guided Isolation of Active Compounds

et al. 2018

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Alpha-glucosidase inhibitory activity has been commonly used for the evaluation of antidiabetic property in vitro. The aim of this study is to investigate and characterize Dalbergia tonkinensis as a potential source of antidiabetic compounds. The screening of the active parts used, such as trunk bark, heartwood, and the leaves of Dalbergia tonkinensis indicated that all these extracted parts used with methanol demonstrated potent α-glucosidase inhibitory activity. The in vitro antidiabetic property of Dalbergia tonkinensis was notably recorded for the first time and showed activity (EC50 = 0.17–0.78 mg/mL) comparable to those of reported potent herbal extracts (EC50 = 0.25–4.0 mg/mL) and higher activity than that of acarbose, a commercial antidiabetic drug (EC50 = 1.21 mg/mL). The stability tests revealed that the heartwood of Dalbergia tonkinensis extract (HDT) possesses high pH stability with relative activity in the range of 80–98%. Further bioassay-guided purification led to the isolation of 2 active compounds identified as sativanone and formononetin from the ethyl acetate fraction and water fraction of HDT, respectively. These α-glucosidase inhibitors (aGIs) show promising inhibition against various types of α-glucosidases. Remarkably, these inhibitors were determined as new mammalian aGIs, showing good effect on rat α-glucosidase. The results suggest that Dalbergia tonkinensis is a potent source of aGIs and suggest promise in being developed as functional food with antidiabetic efficacy. The results of this study also enrich our knowledge concerning current biological activity and constituents of Dalbergia tonkinensis species.

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A Review on the Medicinal Plant Dalbergia odorifera Species: Phytochemistry and Biological Activity

Cited by 45 publications

References 69 publications

Genetic Diversity of the Endangered Dalbergia odorifera Revealed by SSR Markers

Genetic Diversity of the Endangered Dalbergia odorifera Revealed by SSR Markers

6,7,4′‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo

New Records of Potent In-Vitro Antidiabetic Properties of Dalbergia tonkinensis Heartwood and the Bioactivity-Guided Isolation of Active Compounds

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