A Review on the Role of Oxidative Stress and Inflammation in Necrotizing Enterocolitis and Benefits of the Phosphodiesterase Inhibitor Pentoxifylline

Mozaffari, Shilan; Abdollahi, Mohammad

doi:10.3923/ijp.2013.245.250

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…The intestinal hypoxia seen during NEC is caused by hydroxyl free radicals produced in xanthine oxidase-mediated reactions. The present study found elevated activity of xanthine oxidase in intestinal homogenate of NEC neonatal rats, which is consistent with earlier reports [13]. The increased levels of MDA and XO in NEC neonatal rats were significantly reduced by resveratrol treatment.…”

Section: Discussionsupporting

confidence: 93%

Resveratrol ameliorates necrotizing enterocolitis in neonatal rats through regulation of inflammatory and apoptotic pathways

Hu¹,

Chen²,

He³

et al. 2021

Trop. J. Pharm Res

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Purpose: To determine the efficacy of resveratrol in mitigating necrotizing enterocolitis (NEC) in neonatal rats.Methods: Necrotizing enterocolitis (NEC) was induced in neonatal rats using hypoxia and hypothermia. At the completion of treatment, the intestinal tissues of the rats were isolated for evaluation of various biochemical parameters.Results: There was significant increase in the levels of proinflammatory cytokines (TNF-α, IL-6 and IL-1β) and oxidative stress markers (MDA, xanthine oxidase and nitric oxide) in intestinal tissues of NEC rats (p < 0.05). However, resveratrol treatment led to significant decrease in the levels of cytokines and oxidative stress parameters, relative to the NEC group (p < 0.05). Furthermore, Western blotting resultsshowed up-regulation in protein expressions of inflammatory cytokines in NEC rats. However, the protein expressions of inflammatory cytokines were down-regulated in the NEC rats on treatment with resveratrol. Moreover, resveratrol reversed the NEC-induced up-regulations of Bax and caspase-3, as well as NEC-mediated down-regulation of Bcl-2.Conclusion: These results demonstrate that resveratrol mitigates NEC-induced intestinal damage in neonatal rats via anti-inflammatory, anti-apoptotic and antioxidant mechanisms of action. Therefore, resveratrol is a potential therapeutic agent for NEC.

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Section: Discussionsupporting

confidence: 93%